Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells (Q34737702)

4 August 2017

Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells (English)

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4 August 2017

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1

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7 June 2020

Darren F. Boehning

7

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7 June 2020

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Gary D V Hankins

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7 June 2020

6

Ayman Al-Hendy

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7 June 2020

author name string

Gokhan S Kilic

2

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7 June 2020

Chandrasekha Yallampalli

3

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7 June 2020

Russell R Snyder

4

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7 June 2020

language of work or name

English

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publication date

30 October 2014

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Journal of Biological Chemistry

4 August 2017

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7 June 2020

volume

289

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7 June 2020

page(s)

35075-35086

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7 June 2020

issue

51

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T-type calcium channels blockers as new tools in cancer therapies

7 June 2020

cites work

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Ultrasensitive fluorescent proteins for imaging neuronal activity

7 July 2018

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Complex networks of multiple factors in the pathogenesis of uterine leiomyoma

7 July 2018

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Caspase 3 cleavage of the inositol 1,4,5-trisphosphate receptor does not contribute to apoptotic calcium release.

7 July 2018

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Development and validation of a three-dimensional in vitro model for uterine leiomyoma and patient-matched myometrium.

7 July 2018

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Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein

7 July 2018

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A computational model of the ionic currents, Ca2+ dynamics and action potentials underlying contraction of isolated uterine smooth muscle.

7 July 2018

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The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels

7 July 2018

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Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

7 July 2018

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Calcium and ER stress mediate hepatic apoptosis after burn injury.

7 July 2018

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Neuroprotective effects of blockers for T-type calcium channels.

7 July 2018

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Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells

7 July 2018

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Calcium channel regulation in vascular smooth muscle cells: synergistic effects of statins and calcium channel blockers

7 July 2018

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Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase

7 July 2018

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Simvastatin protects against the development of endometriosis in a nude mouse model

7 July 2018

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Incidence, aetiology and epidemiology of uterine fibroids

7 July 2018

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Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice

7 July 2018

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Requirement of inositol 1,4,5-trisphosphate receptors for tumor-mediated lymphocyte apoptosis.

7 July 2018

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Statin induces apoptosis and cell growth arrest in prostate cancer cells

7 July 2018

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Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosis

7 July 2018

1 reference

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Dose-finding study of high-dose simvastatin combined with standard chemotherapy in patients with relapsed or refractory myeloma or lymphoma.

7 July 2018

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Steroid hormones and leiomyomas

7 July 2018

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Statins and cancer prevention

7 July 2018

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The role of statins in cancer prevention and treatment.

7 July 2018

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Uterine fibroids: the elephant in the room

7 July 2018

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Pleiotropic effects of statins

7 July 2018

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A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways

7 July 2018

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Inhibitory effect of statins on the proliferation of human breast cancer cells.

7 July 2018

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Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

7 July 2018

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Blockade of calcium influx through L-type calcium channels attenuates mitochondrial injury and apoptosis in hypoxic renal tubular cells

7 July 2018

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Aromatase and leiomyoma of the uterus

7 July 2018

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Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

7 July 2018

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Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

7 July 2018

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Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

7 July 2018

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Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells

7 July 2018

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Statins can inhibit proliferation of human breast cancer cells in vitro

7 July 2018

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Interactions of cytokines, growth factors, and the extracellular matrix in the cellular biology of uterine leiomyomata

7 July 2018

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Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristics

7 July 2018

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Clinical review 145: Pleiotropic effects of statins: lipid reduction and beyond

7 July 2018

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Calcium entry through L-type calcium channels causes mitochondrial disruption and chromaffin cell death

7 July 2018

1 reference

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Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study

7 July 2018

1 reference

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Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

7 July 2018

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Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization

7 July 2018

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

7 July 2018

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New insights into the pharmacodynamic and pharmacokinetic properties of statins.

7 July 2018

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Current perspectives in the pharmacological studies of store-operated Ca2+ entry blockers

7 July 2018

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Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase

7 July 2018

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BAX is required for neuronal death after trophic factor deprivation and during development

7 July 2018

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Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)

7 July 2018

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Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness

7 July 2018

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A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma

7 July 2018

1 reference

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HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species

21 January 2018

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HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes

21 January 2018

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Simvastatin induces apoptosis of B-CLL cells by activation of mitochondrial caspase 9.

21 January 2018

1 reference

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Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

21 January 2018

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Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells

21 January 2018

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Expression of insulin-like growth factors (IGFs) and IGF signaling: molecular complexity in uterine leiomyomas.

21 January 2018

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Dysregulation of IGF-I signaling in uterine leiomyoma

21 January 2018

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Catecholestrogens induce oxidative stress and malignant transformation in human endometrial glandular cells: protective effect of catechol-O-methyltransferase.

21 January 2018

1 reference

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Simvastatin triggers mitochondria-induced Ca2+ signaling alteration in skeletal muscle

21 January 2018

1 reference

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Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.583575

Physiological induction of transient receptor potential canonical proteins, calcium entry channels, in human myometrium: influence of pregnancy, labor, and interleukin-1 beta

21 January 2018

1 reference

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Characterization of the molecular and electrophysiological properties of the T-type calcium channel in human myometrium.

21 January 2018

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Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a nonsteroidal aromatase inhibitor

21 January 2018

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Inhibition of phospholipase C dependent processes by U-73, 122

21 January 2018

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12 December 2020

First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma

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12 December 2020

Expression of the CYP19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissues and cells in culture

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12 December 2020

Properties of voltage-activated [Ca2+]i transients in single smooth muscle cells isolated from pregnant rat uterus

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12 December 2020

Presence of epidermal growth factor, platelet-derived growth factor, and their receptors in human myometrial tissue and smooth muscle cells: their action in smooth muscle cells in vitro

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12 December 2020

Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps

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12 December 2020

Identifiers

DOI

10.1074/JBC.M114.583575

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25359773%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25359773%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25359773%20AND%20SRC:MED&resulttype=core&format=json