Statins and cancer prevention (Q36337970)

13 August 2017

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title

Statins and cancer prevention (English)

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13 August 2017

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Marie-France Demierre

1

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13 August 2017

Peter D R Higgins

2

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13 August 2017

Stephen B Gruber

3

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13 August 2017

Ernest Hawk

4

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13 August 2017

Scott M Lippman

5

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13 August 2017

language of work or name

English

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publication date

1 December 2005

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13 August 2017

Nature Reviews Cancer

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13 August 2017

5

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13 August 2017

930-942

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13 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrc1751

13 August 2017

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cites work

Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators.

1 reference

Chemoprevention by pravastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, of N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats.

21 January 2018

1 reference

Inhibition of Rho is required for cAMP-induced melanoma cell differentiation.

21 January 2018

1 reference

Might treatment of hypercholesterolaemia increase non-cardiac mortality?

21 January 2018

1 reference

Carcinogenicity of lipid-lowering drugs

31 March 2020

1 reference

Relation between baseline and on-treatment lipid parameters and first acute major coronary events in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS)

31 March 2020

1 reference

Statins for Atherosclerosis — As Good as It Gets?

31 March 2020

1 reference

HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

31 March 2020

1 reference

Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway

31 March 2020

1 reference

Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation

31 March 2020

1 reference

Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention.

31 March 2020

1 reference

Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma

31 March 2020

1 reference

Role of Rho-family proteins in cell adhesion and cancer.

31 March 2020

1 reference

Inverted signaling hierarchy between RAS and RAC in T-lymphocytes.

31 March 2020

1 reference

Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells

31 March 2020

1 reference

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

31 March 2020

1 reference

Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study

31 March 2020

1 reference

Pro-apoptotic effect of fluvastatin on human smooth muscle cells

31 March 2020

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Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

31 March 2020

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Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas.

31 March 2020

1 reference

Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase

31 March 2020

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p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases

31 March 2020

1 reference

Statins: the new aspirin?

31 March 2020

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The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

31 March 2020

1 reference

Inhibition of Hydroxymethylglutaryl-Coenzyme A Reductase Reduces Th1 Development and Promotes Th2 Development

31 March 2020

1 reference

Geranylgeranyl transferase inhibition stimulates anti-melanoma immune response through MHC Class I and costimulatory molecule expression.

31 March 2020

1 reference

Statins have biphasic effects on angiogenesis

31 March 2020

1 reference

Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis

31 March 2020

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The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

31 March 2020

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Statins exert endothelial atheroprotective effects via the KLF2 transcription factor

31 March 2020

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Cerivastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase, inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in in vivo models

31 March 2020

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HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells

31 March 2020

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Statin therapy and angiogenesis

31 March 2020

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Double-edged role of statins in angiogenesis signaling

31 March 2020

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Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis

31 March 2020

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Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis

31 March 2020

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Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism

31 March 2020

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Lovastatin-induced apoptosis of human medulloblastoma cell lines in vitro

31 March 2020

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Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells

31 March 2020

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Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells.

31 March 2020

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Cell cycle-specific effects of lovastatin

31 March 2020

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Lovastatin-induced E2F-1 modulation and its effect on prostate cancer cell death

31 March 2020

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Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis.

31 March 2020

1 reference

Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in tumor cells

31 March 2020

1 reference

Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways

31 March 2020

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Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells

31 March 2020

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C-reactive protein and the risk of incident colorectal cancer

31 March 2020

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Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac

31 March 2020

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Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis.

31 March 2020

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Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic "metastases" in vivo

31 March 2020

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Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention

31 March 2020

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Effect of statins combined with estradiol on the proliferation of human receptor-positive and receptor-negative breast cancer cells

31 March 2020

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Statins can inhibit proliferation of human breast cancer cells in vitro

31 March 2020

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Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

31 March 2020

1 reference

Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study

31 March 2020

1 reference

The Rho-ADP-ribosylating C3 exoenzyme from Clostridium botulinum and related C3-like transferases

31 March 2020

1 reference

Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells

31 March 2020

1 reference

Osteoblast-derived Oxysterol Is a Migration-inducing Factor for Human Breast Cancer Cells

31 March 2020

1 reference

31 March 2020

1 reference

Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects

31 March 2020

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The effects of lovastatin on proteasome activities in highly purified rabbit 20 S proteasome preparations and mouse MC3T3-E1 osteoblastic cells

31 March 2020

1 reference

Lovastatin and simvastatin are modulators of the proteasome.

31 March 2020

1 reference

Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis

31 March 2020

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Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells.

31 March 2020

1 reference

Isoprenylation is necessary for the full invasive potential of RhoA overexpression in human melanoma cells

31 March 2020

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Lovastatin-induced apoptosis in human melanoma cell lines

31 March 2020

1 reference

Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma

31 March 2020

1 reference

Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo

31 March 2020

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3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and the risk of cancer: a nested case-control study

31 March 2020

1 reference

The Risk of Cancer in Users of Statins

31 March 2020

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Statin use and cancer risk in the General Practice Research Database

31 March 2020

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Statin use, hyperlipidaemia, and the risk of breast cancer

31 March 2020

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Cancer risk among statin users: a population-based cohort study

31 March 2020

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Statins and prostate cancer risk: a case-control study

31 March 2020

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Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models

31 March 2020

1 reference

Statins and the risk of colorectal cancer

31 March 2020

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Reported use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors was not associated with reduced recurrence of colorectal adenomas

31 March 2020

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Statin use and the risk of breast cancer

31 March 2020

1 reference

Lipid-Lowering Drug Use and Breast Cancer in Older Women: A Prospective Study

31 March 2020

1 reference

Statin use and the risk of breast and prostate cancer

31 March 2020

1 reference

The association between 3-hydroxy-3-methylglutaryl conenzyme A inhibitor use and breast carcinoma risk among postmenopausal women: a case-control study.

31 March 2020

1 reference

Melanoma chemoprevention: a role for statins or fibrates?

31 March 2020

1 reference

Prior medical conditions and medication use and risk of non-Hodgkin lymphoma in Connecticut United States women

31 March 2020

1 reference

Statins and cancer development.

31 March 2020

1 reference

Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S).

31 March 2020

1 reference

Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group

31 March 2020

1 reference

The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators

31 March 2020

1 reference

Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels

31 March 2020

1 reference

Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study

31 March 2020

1 reference

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial

31 March 2020

1 reference

Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial

31 March 2020

1 reference

Safety and tolerability of pravastatin in long-term clinical trials: prospective Pravastatin Pooling (PPP) Project

31 March 2020

1 reference

Cholesterol lowering with statin drugs, risk of stroke, and total mortality. An overview of randomized trials

31 March 2020

1 reference

Do statins cause cancer? A meta-analysis of large randomized clinical trials

31 March 2020

1 reference

Statins and cancer: a case of meta-uncertainty

31 March 2020

1 reference

Statins as anti-inflammatory agents

31 March 2020

1 reference

Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer

31 March 2020

1 reference

Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications.

31 March 2020

1 reference

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

31 March 2020

1 reference

Pleiotropic effects of statins

31 March 2020

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Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.

31 March 2020

1 reference

Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication

31 March 2020

1 reference

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

31 March 2020

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The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors

31 March 2020

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Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo

31 March 2020

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RETRACTED: Non-steroidal anti-inflammatory drugs and the risk of oral cancer: a nested case-control study

31 March 2020

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Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor

31 March 2020

1 reference

Statins and cancer--beyond the "one drug, one disease" model

31 March 2020

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Intensive statin therapy--a sea change in cardiovascular prevention

31 March 2020

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Statins differ in their ability to block NF-kB activation in human blood monocytes

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1751

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Dimensions Publication ID

13 August 2017

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