Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis (Q34747455)

4 August 2017

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title

Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis (English)

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4 August 2017

John Varga

1

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PubMed ID

12124852

4 August 2017

language of work or name

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1 July 2002

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4 August 2017

Arthritis & Rheumatology

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4 August 2017

46

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4 August 2017

7

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4 August 2017

1703-1713

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Transforming growth factor beta s and wound healing

4 August 2017

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Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta

21 January 2018

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Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.

21 January 2018

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Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis

21 January 2018

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Mast cells, extracellular matrix components, TGFbeta isoforms and TGFbeta receptor expression in labial salivary glands in systemic sclerosis

21 January 2018

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Immunocytochemical localization and serologic detection of transforming growth factor beta 1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon

21 January 2018

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Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis

21 January 2018

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Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice

21 January 2018

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Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice

21 January 2018

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Transforming growth factor-beta2 antibody attenuates fibrosis in the experimental diabetic rat kidney

21 January 2018

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Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

21 January 2018

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Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

21 January 2018

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The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases

21 January 2018

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Manipulation of TGF-beta to control autoimmune and chronic inflammatory diseases

21 January 2018

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Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice.

21 January 2018

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How cells read TGF-beta signals

21 January 2018

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Human Smad3 and Smad4 are sequence-specific transcription activators

21 January 2018

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Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1.

21 January 2018

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Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts: association with increased expression of the type I collagen gene

21 January 2018

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Transcriptional control by the TGF-beta/Smad signaling system

21 January 2018

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Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach.

21 January 2018

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Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta, and p38.

21 January 2018

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Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific alpha 2(I) collagen gene transcription

21 January 2018

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Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

21 January 2018

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The role of Smad3 in mediating mouse hepatic stellate cell activation

21 January 2018

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Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3.

21 January 2018

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TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

21 January 2018

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CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling

21 January 2018

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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

21 January 2018

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A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling

21 January 2018

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Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

21 January 2018

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Ultraviolet irradiation blocks cellular responses to transforming growth factor-beta by down-regulating its type-II receptor and inducing Smad7.

21 January 2018

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Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis

21 January 2018

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Putting the brakes on arthritis: can suppressors of cytokine signaling (SOCS) suppress rheumatoid arthritis?

21 January 2018

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Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

21 January 2018

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Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells

21 January 2018

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The transforming growth factor-beta/SMAD signaling pathway is present and functional in human mesangial cells

21 January 2018

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Microtubule binding to Smads may regulate TGF beta activity

21 January 2018

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A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

21 January 2018

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Differential regulation of TGF-beta signal in hepatic stellate cells between acute and chronic rat liver injury

21 January 2018

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Deficient Smad7 expression: a putative molecular defect in scleroderma

21 January 2018

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Localization of Smad6 and Smad7 in the rat kidney and their regulated expression in the anti-Thy-1 nephritis

21 January 2018

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Apoptosis in podocytes induced by TGF-beta and Smad7

21 January 2018

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Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblasts

21 January 2018

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Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse

21 January 2018

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Activation of the TGF-beta/activin-Smad2 pathway during allergic airway inflammation

21 January 2018

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Functions of mammalian Smad genes as revealed by targeted gene disruption in mice

21 January 2018

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Smad3 mutant mice develop metastatic colorectal cancer

21 January 2018

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Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

21 January 2018

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

21 January 2018

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Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

21 January 2018

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Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

21 January 2018

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Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation

21 January 2018

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Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts.

21 January 2018

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SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.

21 January 2018

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

21 January 2018

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Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins

21 January 2018

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Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation

21 January 2018

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Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer.

21 January 2018

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Induction of platelet-derived growth factor B-chain expression by transforming growth factor-beta involves transactivation by Smads

21 January 2018

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Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling.

21 January 2018

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Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts

21 January 2018

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Elevation of Expression of Smads 2, 3, and 4, Decorin and TGF-βin the Chronic Phase of Myocardial Infarct Scar Healing

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ART.10413

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4 August 2017

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PubMed ID

12124852