Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms (Q34756486)

4 August 2017

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title

Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms (English)

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4 August 2017

3

Guy Boivin

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4 August 2017

Christian Gilbert

1

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PubMed ID

12135584

4 August 2017

Julie Bestman-Smith

series ordinal

2

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PubMed ID

12135584

4 August 2017

language of work or name

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1 April 2002

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4 August 2017

Drug Resistance Updates

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4 August 2017

5

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4 August 2017

88-114

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4 August 2017

2

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Value of a new rapid non-radioactive sequencing method for analysis of the cytomegalovirus UL97 gene in ganciclovir-resistant strains.

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Differential Susceptibility of Several Drug-Resistant Strains of Herpes Simplex Virus Type 2 to Various Antiviral Compounds

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Herpesviral deoxythymidine kinases contain a site analogous to the phosphoryl-binding arginine-rich region of porcine adenylate kinase; comparison of secondary structure predictions and conservation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recov

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Ganciclovir resistance as a result of oral ganciclovir in a heart transplant recipient with multiple human cytomegalovirus strains in blood

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Coinfection of the immunocompromised but not the immunocompetent host by multiple human cytomegalovirus strains

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Mutations in the UL97 ORF of ganciclovir-resistant clinical cytomegalovirus isolates differentially affect GCV phosphorylation as determined in a recombinant vaccinia virus system

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

1 reference

7 January 2021

Failure of foscarnet in disseminated herpes zoster

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A conserved 3'----5' exonuclease active site in prokaryotic and eukaryotic DNA polymerases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Highly reliable heterologous system for evaluating resistance of clinical herpes simplex virus isolates to nucleoside analogues

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A general structure for DNA-dependent DNA polymerases.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Acyclovir-resistant bilateral keratitis associated with mutations in the HSV-1 thymidine kinase gene.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Acyclovir susceptibilities of herpes simplex virus strains isolated from solid organ transplant recipients after acyclovir or ganciclovir prophylaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Ganciclovir susceptibilities of cytomegalovirus (CMV) isolates from solid organ transplant recipients with CMV viremia after antiviral prophylaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Phenotypic and genotypic characterization of acyclovir-resistant varicella-zoster viruses isolated from persons with AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Detection of ganciclovir resistance mutations quantitation of cytomegalovirus (CMV) DNA in leukocytes of patients with fatal disseminated CMV disease

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A case of ganciclovir-resistant cytomegalovirus (CMV) retinitis in a patient with AIDS: longitudinal molecular analysis of the CMV viral load and viral mutations in blood compartments

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Rate of emergence of cytomegalovirus (CMV) mutations in leukocytes of patients with acquired immunodeficiency syndrome who are receiving valganciclovir as induction and maintenance therapy for CMV retinitis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Antiviral susceptibilities of herpes simplex virus from immunocompetent subjects with recurrent herpes labialie: a UK-based survey

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Value of a ligase chain reaction assay for detection of ganciclovir resistance-related mutation 594 in UL97 gene of human cytomegalovirus

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Resistance to antiviral drugs in herpes simplex virus infections among allogeneic stem cell transplant recipients: risk factors and prognostic significance

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex viruses

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Resistant herpes simplex virus type 1 infection: an emerging concern after allogeneic stem cell transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Susceptibility of human cytomegalovirus to cidofovir is unchanged after limited in vivo exposure to various regimens of drug

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

In vitro antiviral susceptibilities of isolates from cytomegalovirus retinitis patients receiving first- or second-line cidofovir therapy: relationship to clinical outcome.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A deletion mutation in region V of the cytomegalovirus DNA polymerase sequence confers multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Cytomegalovirus UL97 phosphotransferase mutations that affect susceptibility to ganciclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Foscarnet. A review of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with cytomegalovirus retinitis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Sensitivity monitoring of clinical isolates of herpes simplex virus to acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Mechanism of action of foscarnet against viral polymerases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A cosmid-based system for constructing mutants of herpes simplex virus type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Resistance to antiviral inhibitors caused by the mutation S889A in the highly-conserved 885-GDTDS motif of the herpes simplex virus type 1 DNA polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Prevalence of Resistance in Patients Receiving Ganciclovir for Serious Cytomegalovirus Infection

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Failure of high-dose oral acyclovir to suppress CMV viruria or induce ganciclovir-resistant CMV in HIV antibody positive patients

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Cytomegalovirus (CMV) resistance in patients with CMV retinitis and AIDS treated with oral or intravenous ganciclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Antiviral activity of a selective ribonucleotide reductase inhibitor against acyclovir-resistant herpes simplex virus type 1 in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Homology between DNA polymerases of poxviruses, herpesviruses, and adenoviruses: nucleotide sequence of the vaccinia virus DNA polymerase gene

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Prediction of cytomegalovirus load and resistance patterns after antiviral chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

The dynamics of human cytomegalovirus replication in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Herpes simplex virus resistant to acyclovir. A study in a tertiary care center

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Ganciclovir susceptibilities and analysis of UL97 region in cytomegalovirus (CMV) isolates from bone marrow recipients with CMV disease after antiviral prophylaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Genetic analysis of a ganciclovir-resistant human cytomegalovirus mutant

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Recurrence and resistance patterns of herpes simplex virus following cessation of > or = 6 years of chronic suppression with acyclovir. Acyclovir Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Foscarnet-resistant multidermatomal zoster in a patient with AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Pathophysiology and treatment of clinically resistant cytomegalovirus retinitis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Monitoring of ganciclovir sensitivity of multiple human cytomegalovirus strains coinfecting blood of an AIDS patient by an immediate-early antigen plaque assay.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Emergence and prevalence of cytomegalovirus UL97 mutations associated with ganciclovir resistance in AIDS patients.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Lack of emergence of cytomegalovirus UL97 mutations conferring ganciclovir (GCV) resistance following preemptive GCV therapy in allogeneic stem cell transplant recipients

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Aphidicolin resistance in herpes simplex virus type I reveals features of the DNA polymerase dNTP binding site

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Genetic analysis of a clinical isolate of human cytomegalovirus exhibiting resistance against both ganciclovir and cidofovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

In vitro and in vivo characterization of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Allele replacement: an application that permits rapid manipulation of herpes simplex virus type 1 genomes

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

An altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene can confer altered drug sensitivities

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

GCV resistance due to the mutation A594P in the cytomegalovirus protein UL97 is partially reconstituted by a second mutation at D605E.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Cytomegalovirus retinitis and viral resistance. Prevalence of resistance at diagnosis, 1994. Cytomegalovirus Retinitis and Viral Resistance Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Cytomegalovirus retinitis and viral resistance: ganciclovir resistance. CMV Retinitis and Viral Resistance Study Group.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Mutations conferring ganciclovir resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Biochemical studies on the herpes simplex virus-specified deoxypyrimidine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Characterization of the DNA polymerase gene of varicella-zoster viruses resistant to acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Comparison of human cytomegalovirus DNA polymerase activity for ganciclovir-resistant and -sensitive clinical strains

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Nucleotide sequence changes in thymidine kinase gene of herpes simplex virus type 2 clones from an isolate of a patient treated with acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

The herpes simplex virus type 1 DNA polymerase gene: site of phosphonoacetic acid resistance mutation in strain Angelotti is highly conserved

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Properties of Herpes Simplex Virus DNA Polymerase and Characterization of Its Associated Exonuclease Activity

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Brief report: recurrent acyclovir-resistant genital herpes in an immunocompetent patient.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

The impact of ganciclovir-resistant cytomegalovirus infection after lung transplantation.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: analysis of clinical isolates from herpetic keratitis patients and laboratory strains

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Herpes simplex virus type 1 DNA polymerase. Mutational analysis of the 3'-5'-exonuclease domain

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A standardized plaque reduction assay for determination of drug susceptibilities of cytomegalovirus clinical isolates

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Role of genotypic analysis of the thymidine kinase gene of herpes simplex virus for determination of neurovirulence and resistance to acyclovir.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A potent peptidomimetic inhibitor of HSV ribonucleotide reductase with antiviral activity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Molecular analysis of human cytomegalovirus strains from two lung transplant recipients with the same donor

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

The structure and function of the HSV DNA replication proteins: defining novel antiviral targets

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A colorimetric assay for the measurement of the sensitivity of herpes simplex viruses to antiviral agents

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Susceptibilities of human cytomegalovirus clinical isolates to BAY38-4766, BAY43-9695, and ganciclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Novel mutation in the CMV UL97 gene associated with resistance to ganciclovir therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Phenotypic and genetic characterization of thymidine kinase from clinical strains of varicella-zoster virus resistant to acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Genetic characterization of thymidine kinase from acyclovir-resistant and -susceptible herpes simplex virus type 1 isolated from bone marrow transplant recipients

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922)

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Rising pp65 antigenemia during preemptive anticytomegalovirus therapy after allogeneic hematopoietic stem cell transplantation: risk factors, correlation with DNA load, and outcomes

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Occurrence and characterization of acyclovir‐resistant herpes simplex virus isolates: Report on a two—year sensitivity screening survey

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Characterization of an acyclovir-resistant herpes simplex virus type 2 strain isolated from a premature neonate.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A point mutation in the thymidine kinase gene is responsible for acyclovir-resistance in herpes simplex virus type 2 sequential isolates

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Flow cytometric analysis of herpes simplex virus type 1 susceptibility to acyclovir, ganciclovir, and foscarnet.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Acyclovir resistance in herpes simplex virus isolates from keratitis cases: an analysis from a developing country

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Comprehensive restriction analysis of the UL97 region allows early detection of ganciclovir-resistant human cytomegalovirus in an immunocompromised child

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Purification and photoaffinity labeling of herpes simplex virus type-1 thymidine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Development of ganciclovir resistance during treatment of primary cytomegalovirus infection after liver transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Foscarnet therapy for acyclovir-resistant mucocutaneous herpes simplex virus infection in 26 AIDS patients: preliminary data

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Foscarnet Therapy in Five Patients with AIDS and Acyclovir-resistant Varicella-Zoster Virus Infection

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A controlled trial comparing foscarnet with vidarabine for acyclovir-resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Foscarnet-resistant herpes simplex virus infection in patients with AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A rapid phenotypic assay for detection of acyclovir-resistant varicella-zoster virus with mutations in the thymidine kinase open reading frame

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Clinical and virologic characterization of acyclovir-resistant varicella-zoster viruses isolated from 11 patients with acquired immunodeficiency syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Double resistance to ganciclovir and foscarnet of four human cytomegalovirus strains recovered from AIDS patients

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Characterization of herpes simplex viruses selected in culture for resistance to penciclovir or acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Spontaneous reactivation of thymidine kinase-deficient, acyclovir-resistant type-2 herpes simplex virus: masked heterogeneity or reversion?

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Molecular analysis of the pyrimidine deoxyribonucleoside kinase gene of wild-type and acyclovir-resistant strains of varicella-zoster virus

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Characterization of the DNA polymerase and thymidine kinase genesof herpes simplex virus isolates from AIDS patients in whom acyclovirand foscarnet therapy sequentially failed

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Ganciclovir sensitivity of cytomegalovirus at diagnosis and during treatment of cytomegalovirus pneumonia in marrow transplant recipients.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Polyradiculopathy associated with ganciclovir-resistant cytomegalovirus in an AIDS patient: phenotypic and genotypic characterization of sequential virus isolates

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A New Topical Treatment for Resistant Herpes Simplex Infections

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Molecular detection of human cytomegalovirus and determination of genotypic ganciclovir resistance in clinical specimens

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Ganciclovir-resistant cytomegalovirus clinical isolates: mode of resistance to ganciclovir

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Chronic vulvar ulceration in an immunocompetent woman due to acyclovir-resistant, thymidine kinase-deficient herpes simplex virus

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Improved DNA hybridization method for detection of acyclovir-resistant herpes simplex virus

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Molecular analysis of a neurovirulent herpes simplex virus type 2 strain with reduced thymidine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A ganciclovir-resistant clinical isolate of human cytomegalovirus exhibiting cross-resistance to other DNA polymerase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

A single-base change within the DNA polymerase locus of herpes simplex virus type 2 can confer resistance to aphidicolin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Single amino acid change in DNA polymerase is associated with foscarnet resistance in a varicella-zoster virus strain recovered from a patient with AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Intravenous acyclovir to treat mucocutaneous herpes simplex virus infection after marrow transplantation: a double-blind trial

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Acyclovir: A Decade Later

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Replication, latent infection, and reactivation in neuronal culture with a herpes simplex virus thymidine kinase-negative mutant

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Detection of human cytomegalovirus mutations associated with ganciclovir resistance in cerebrospinal fluid of AIDS patients with central nervous system disease

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Early emergence of ganciclovir-resistant human cytomegalovirus strains in children with primary combined immunodeficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Distinct and separate roles for herpesvirus-conserved UL97 kinase in cytomegalovirus DNA synthesis and encapsidation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

Primary structure of the catalytic subunit of calf thymus DNA polymerase .delta.: sequence similarities with other DNA polymerases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2802%2900021-3

7 January 2021

10.1016/S1368-7646(02)00021-3

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12135584