Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders. (Q34761363)

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English	Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.	scientific article

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24 January 2020

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Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders (English)

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24 January 2020

central nervous system disease

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25 April 2019

31 July 2019

2 October 2019

15 December 2019

cell surface receptor

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31 July 2019

mechanism of action

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2 October 2019

membrane protein

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15 December 2019

M. Foster Olive

2

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24 January 2020

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Richard M Cleva

1

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2 March 2011

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24 January 2020

5 references

25 April 2019

31 July 2019

2 October 2019

15 December 2019

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24 January 2020

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24 January 2020

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24 January 2020

2097-2106

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24 January 2020

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Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory

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ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activiti

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Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm

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Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex

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Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges

1 reference

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1 reference

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Pharmacology and functions of metabotropic glutamate receptors

1 reference

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Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070661

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Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070661

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Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070661

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MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: relevance to negative symptoms associated with schizophrenia?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070661

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Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070661

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Cellular localization of mGluR3 and mGluR5 mRNAs in normal and injured rat brain.

1 reference

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26 October 2018

Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070661

26 October 2018

Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21368721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21368721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21368721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mGluR3 and mGluR5 are the predominant metabotropic glutamate receptor mRNAs expressed in hippocampal astrocytes acutely isolated from young rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21368721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/MOLECULES16032097

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368721%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368721%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368721%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

ResearchGate publication ID

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