Asthma: an epidemic of dysregulated immunity (Q34765268)

4 August 2017

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title

Asthma: an epidemic of dysregulated immunity (English)

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4 August 2017

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Jennifer J McIntire

2

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author name string

Dale T Umetsu

1

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4 August 2017

Omid Akbari

3

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4 August 2017

Claudia Macaubas

4

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4 August 2017

Rosemarie H DeKruyff

5

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4 August 2017

language of work or name

English

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publication date

1 August 2002

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4 August 2017

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4 August 2017

3

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4 August 2017

8

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4 August 2017

715-720

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https://scigraph.springernature.com/pub.10.1038/ni0802-715

4 August 2017

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cites work

The alliance of genes and environment in asthma and allergy

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Airway inflammation and remodeling in asthma

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

The environmental predictors of allergic disease

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Hay fever, hygiene, and household size

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Skin test reactivity and number of siblings

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Siblings, day-care attendance, and the risk of asthma and wheezing during childhood

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Early exposure to infections and antibiotics and the incidence of allergic disease: a birth cohort study with the West Midlands General Practice Research Database

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

The inverse association between tuberculin responses and atopic disorder.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Mycobacterium tuberculosis infection and the subsequent development of asthma and allergic conditions

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Prevalence of allergy in children in relation to prior BCG vaccination and infection with atypical mycobacteria

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Relationship of viral infections to wheezing illnesses and asthma

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

The intestinal microflora in allergic Estonian and Swedish 2-year-old children

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Exposure to endotoxin decreases the risk of atopic eczema in infancy: a cohort study

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Genes other than TLR4 are involved in the response to inhaled LPS.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Developing Patterns of T Cell Memory to Environmental Allergens in the First Two Years of Life

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Functional diversity of helper T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

The role of helper T cell products in mouse B cell differentiation and isotype regulation

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Late complications of immune deviation therapy in a nonhuman primate

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-gamma/delta+ T cells or interferon (IFN)-gamma in a murine model of allergen sensitization

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Mechanisms preventing allergen-induced airways hyperreactivity: role of tolerance and immune deviation

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Peripheral deletion of antigen-reactive T cells in oral tolerance.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Critical role of B cells in the development of T cell tolerance to aeroallergens.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

ICOS is critical for CD40-mediated antibody class switching

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Role of cytokines in the differentiation of CD4+ T-cell subsets in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

T-regulatory 1 cells: a novel subset of CD4 T cells with immunoregulatory properties.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Role of interleukin 10 in specific immunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Characterization of human inducible costimulator ligand expression and function

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

ICOS co-stimulatory receptor is essential for T-cell activation and function

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

TH1 and TH2 CD4+ cells in human allergic diseases

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Suppression of asthma-like responses in different mouse strains by oral tolerance.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Respiratory infection with influenza A virus interferes with the induction of tolerance to aeroallergens

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Modulation of inhaled antigen-induced IgE tolerance by ongoing Th2 responses in the lung.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Allergy, parasites, and the hygiene hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Grain feeding and the dissemination of acid-resistant Escherichia coli from cattle.

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Clinical and immunologic effects of a rush sublingual immunotherapy to Parietaria species: A double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study).

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Long-term clinical efficacy of grass-pollen immunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity

1 reference

https://api.crossref.org/works/10.1038%2FNI0802-715

7 January 2021

Identifiers

DOI

10.1038/NI0802-715

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Dimensions Publication ID

4 August 2017

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1 reference