In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. (Q36370315)

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English	In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.	scientific article

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7 December 2019

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines (English)

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7 December 2019

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7 December 2019

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7 December 2019

René de Waal Malefyt

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7 December 2019

Catherine M. Hawrylowicz

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7 December 2019

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Franck J Barrat

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7 December 2019

Daniel J Cua

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7 December 2019

David F Richards

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7 December 2019

Chad Crain

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7 December 2019

Huub F Savelkoul

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7 December 2019

Robert L Coffman

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1 March 2002

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7 December 2019

Journal of Experimental Medicine

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7 December 2019

603-616

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7 December 2019

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7 December 2019

Regulatory T cells in the control of immune pathology.

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30 September 2017

Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.

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30 September 2017

IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.

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30 September 2017

Interleukin-10 and the interleukin-10 receptor

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30 September 2017

Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells

1 reference

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30 September 2017

The molecular basis of T helper 1 and T helper 2 cell differentiation

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30 September 2017

Lineage commitment in the immune system: the T helper lymphocyte grows up.

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30 September 2017

GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

1 reference

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30 September 2017

Regulatory T cells: key controllers of immunologic self-tolerance

1 reference

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30 September 2017

A novel transcription factor, T-bet, directs Th1 lineage commitment

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30 September 2017

Induction of resistance to active experimental allergic encephalomyelitis by myelin basic protein-specific Th2 cell lines generated in the presence of glucocorticoids and IL-4.

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30 September 2017

Innate immune recognition: mechanisms and pathways

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30 September 2017

The third function of the thymus.

1 reference

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30 September 2017

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

1 reference

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30 September 2017

Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo

1 reference

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30 September 2017

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

1 reference

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30 September 2017

Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

1 reference

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30 September 2017

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.

1 reference

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30 September 2017

Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis

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30 September 2017

Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis

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30 September 2017

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

1 reference

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30 September 2017

Role of interleukin 10 in specific immunotherapy

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30 September 2017

Dendritic cells and the control of immunity

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30 September 2017

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways

1 reference

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30 September 2017

Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo

1 reference

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30 September 2017

Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.

1 reference

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30 September 2017

Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation

1 reference

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30 September 2017

Innate immunity: the virtues of a nonclonal system of recognition

1 reference

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30 September 2017

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1 reference

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30 September 2017

A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens

1 reference

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30 September 2017

Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Transforming growth factor beta (TGF-beta)-dependent inhibition of T helper cell 2 (Th2)-induced autoimmunity by self-major histocompatibility complex (MHC) class II-specific, regulatory CD4(+) T cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis

1 reference

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30 September 2017

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

1 reference

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30 September 2017

Homing of naive, memory and effector lymphocytes

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30 September 2017

Tolerance, danger, and the extended family

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30 September 2017

Lymphokine production by human T cells in disease states

1 reference

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30 September 2017

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Genetic variation in the stress response: susceptibility to experimental allergic encephalomyelitis and implications for human inflammatory disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Regulation of immunity to parasites by T cells and T cell-derived cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Oral tolerance for the treatment of autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

30 September 2017

Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

28 June 2018

GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

28 June 2018

Cytokines induce the development of functionally heterogeneous T helper cell subsets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

28 June 2018

Glucocorticoids and immune function: unknown dimensions and new frontiers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

28 June 2018

Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

28 June 2018

Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

28 June 2018

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

28 June 2018

Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

21 September 2018

New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

21 September 2018

Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

21 September 2018

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193760

21 September 2018

Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of immune pathology by regulatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids inhibit calcium- and calcineurin-dependent activation of the human IL-4 promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin D and the immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new type of CD4+ suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11877483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.20011629

1 reference

Europe PubMed Central

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7 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11877483%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference

Europe PubMed Central

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7 December 2019

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