Dubble or nothing? Is HAUSP deubiquitylating enzyme the final arbiter of p53 levels? (Q34767980)

4 August 2017

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title

Dubble or nothing? Is HAUSP deubiquitylating enzyme the final arbiter of p53 levels? (English)

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4 August 2017

Stephen A Wood

1

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4 August 2017

30 July 2002

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Science's STKE : signal transduction knowledge environment

4 August 2017

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4 August 2017

2002

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4 August 2017

143

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4 August 2017

pe34

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

4 August 2017

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Regulation of the p53 tumor suppressor protein

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

A new ticket for entry into budding vesicles-ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Ubiquitin-mediated proteolysis: biological regulation via destruction

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Control of cell fate by a deubiquitinating enzyme encoded by the fat facets gene

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Endoplasmic reticulum-associated protein degradation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

MEKK1/JNK signaling stabilizes and activates p53.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

A common human skin tumour is caused by activating mutations in beta-catenin

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

The many faces of the tumor suppressor gene APC

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

beta-catenin signaling and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Cellular proteins localized at and interacting within ND10/PML nuclear bodies/PODs suggest functions of a nuclear depot

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

PML interaction with p53 and its role in apoptosis and replicative senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

Genetic interactions with Rap1 and Ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

JAK2 is required for induction of the murine DUB-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2002.143.PE34

10.1126/STKE.2002.143.PE34

21 January 2018

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12149513