Antifungals targeted to protein modification: focus on protein N-myristoyltransferase (Q34768569)

4 August 2017

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title

Antifungals targeted to protein modification: focus on protein N-myristoyltransferase (English)

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4 August 2017

author name string

Nafsika H Georgopapadakou

series ordinal

1

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4 August 2017

language of work or name

English

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publication date

1 August 2002

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Expert Opinion on Investigational Drugs

4 August 2017

published in

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4 August 2017

volume

11

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4 August 2017

issue

8

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4 August 2017

page(s)

1117-1125

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National surveillance of nosocomial blood stream infection due to Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE Program.

4 August 2017

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Update on antifungals targeted to the cell wall: focus on beta-1,3-glucan synthase inhibitors

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Antifungal resistance in non- albicans Candida species

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Antifungals targeted to sphingolipid synthesis: focus on inositol phosphorylceramide synthase

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The biology and enzymology of protein N-myristoylation

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N-myristoyltransferase

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Purification and characterization of yeast myristoyl CoA:protein N-myristoyltransferase.

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Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

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Molecular mechanics of calcium-myristoyl switches

21 January 2018

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Immunochemical characterization of human N-myristoyltransferase: evidence for more than one form of the enzyme

21 January 2018

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Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction

21 January 2018

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Increased N-myristoyltransferase activity observed in rat and human colonic tumors

21 January 2018

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N-Myristoyltransferase overexpression in human colorectal adenocarcinomas

21 January 2018

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In vitro antiviral activities of myristic acid analogs against human immunodeficiency and hepatitis B viruses

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Disruption of the yeast N-myristoyl transferase gene causes recessive lethality.

21 January 2018

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Biochemical studies of Saccharomyces cerevisiae myristoyl-coenzyme A:protein N-myristoyltransferase mutants

21 January 2018

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Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans.

21 January 2018

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Genetic studies reveal that myristoylCoA:protein N-myristoyltransferase is an essential enzyme in Candida albicans

21 January 2018

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The structure of myristoyl-CoA:protein N-myristoyltransferase

21 January 2018

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N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences

21 January 2018

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N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence

21 January 2018

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Characterization of a polyhistidine-tagged form of human myristoyl-CoA: protein N-myristoyltransferase produced in Escherichia coli.

21 January 2018

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N-myristoyl transferase assay using phosphocellulose paper binding

21 January 2018

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A continuous fluorometric assay of myristoyl-coenzyme A:protein N-myristoyltransferase

21 January 2018

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An assay for myristoyl-CoA: protein N-myristoyltransferase activity based on ion-exchange exclusion of [3H]myristoyl peptide.

21 January 2018

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Crystal structure of the anti-fungal target N-myristoyl transferase

21 January 2018

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Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs

21 January 2018

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Functional analysis of protein N-myristoylation: metabolic labeling studies using three oxygen-substituted analogs of myristic acid and cultured mammalian cells provide evidence for protein-sequence-specific incorporation and analog-specific redistr

21 January 2018

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Design and syntheses of potent and selective dipeptide inhibitors of Candida albicans myristoyl-CoA:protein N-myristoyltransferase

21 January 2018

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Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase

21 January 2018

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Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifung

21 January 2018

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Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy

21 January 2018

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Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent.

21 January 2018

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A feature based pharmacophore for Candida albicans MyristoylCoA: protein N-myristoyltransferase inhibitors

21 January 2018

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Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1.

21 January 2018

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Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis

21 January 2018

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Crystallographic phasing of myristoyl-CoA-protein N-myristoyltransferase using an iodinated analog of myristoyl-CoA.

21 January 2018

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Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis

21 January 2018

1 reference

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10.1517/13543784.11.8.1117

21 January 2018

Identifiers

DOI

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4 August 2017

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