S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models (Q34784727)

4 August 2017

title

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models (English)

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4 August 2017

Trevor Sharp

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Mariusz Papp

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Mariusz Papp

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author name string

Anne Dekeyne

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4 August 2017

Clotilde Mannoury la Cour

2

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4 August 2017

Alain Gobert

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4 August 2017

Mauricette Brocco

4

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4 August 2017

Françoise Lejeune

5

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4 August 2017

Florence Serres

6

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4 August 2017

Annie Daszuta

8

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4 August 2017

Amélie Soumier

9

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4 August 2017

Jean-Michel Rivet

11

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4 August 2017

Gunnar Flik

12

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4 August 2017

Thomas I Cremers

13

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4 August 2017

Olivier Muller

14

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4 August 2017

Gilbert Lavielle

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4 August 2017

Mark J Millan

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4 August 2017

publication date

4 June 2008

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4 August 2017

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4 August 2017

volume

199

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4 August 2017

issue

4

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4 August 2017

page(s)

549-568

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m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors

4 August 2017

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Dopamine and serotonin: influences on male sexual behavior

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00213-008-1177-9

Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00213-008-1177-9

In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00213-008-1177-9

Distribution of the 5-hydroxytryptamine2C receptor protein in adult rat brain and spinal cord determined using a receptor-directed antibody: effect of 5,7-dihydroxytryptamine

21 January 2018

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12 December 2020

Effects of single and repeated electroconvulsive shock on the social and agonistic behaviour of resident rats

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12 December 2020

A neurotrophic model for stress-related mood disorders

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12 December 2020

5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential

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12 December 2020

The nigrostriatal dopamine system: a neglected target for 5-HT2C receptors

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12 December 2020

5-HT1A-receptor subtype mediates the effect of fluvoxamine, a selective serotonin reuptake inhibitor, on marble-burying behavior in mice

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12 December 2020

Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety

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12 December 2020

5-Hydroxytryptamine2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation

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12 December 2020

Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptors.

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12 December 2020

5HT2C receptor agonists exhibit antidepressant-like properties in the anhedonia model of depression in rats

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12 December 2020

Serotonin, the periaqueductal gray and panic

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12 December 2020

Altered RNA editing of serotonin 2C receptor in a rat model of depression

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12 December 2020

Antidepressant-like properties of the anti-Parkinson agent, piribedil, in rodents: mediation by dopamine D2 receptors

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12 December 2020

S33005, a novel ligand at both serotonin and norepinephrine transporters: II. Behavioral profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.

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12 December 2020

Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine (m-CPP) in patients with generalized social anxiety disorder, panic disorder and healthy controls

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12 December 2020

Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environment

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12 December 2020

Behavioral, neurochemical, anatomical and electrophysiological correlates of panic disorder: multiple transmitter interaction and neuropeptide colocalization

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12 December 2020

Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction

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12 December 2020

Shock-induced ultrasonic vocalization in young adult rats: a model for testing putative anti-anxiety drugs

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12 December 2020

Central serotonin2C receptor: from physiology to pathology

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12 December 2020

SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety

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12 December 2020

Distribution of serotonin 5-HT2C receptors in the ventral tegmental area

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12 December 2020

The mesolimbic dopamine reward circuit in depression

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12 December 2020

S33138 (N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1] benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenyl-acetamide), a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent: III. Actions in models of therapeutic

1 reference

12 December 2020

Functional magnetic resonance imaging and c-Fos mapping in rats following an anorectic dose of m-chlorophenylpiperazine

1 reference

12 December 2020

Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems

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12 December 2020

Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis

1 reference

12 December 2020

Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies

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12 December 2020

Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram

1 reference

12 December 2020

Reciprocal autoreceptor and heteroreceptor control of serotonergic, dopaminergic and noradrenergic transmission in the frontal cortex: relevance to the actions of antidepressant agents

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12 December 2020

Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

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12 December 2020

Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo

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12 December 2020

Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone

1 reference

12 December 2020

Antidepressant treatment and rodent aggressive behaviour

1 reference

12 December 2020

Serotonin and the neurobiology of the ejaculatory threshold

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12 December 2020

Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade

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12 December 2020

Psychomotor slowing, neuroendocrine responses, and behavioral changes after oral administration of meta-chlorophenylpiperazine in normal volunteers

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12 December 2020

Functional significance of adult neurogenesis

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12 December 2020

Selective activation of 5-HT(2C) receptors stimulates GABA-ergic function in the rat substantia nigra pars reticulata: a combined in vivo electrophysiological and neurochemical study

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12 December 2020

Discriminative stimulus properties of m-chlorophenylpiperazine.

1 reference

12 December 2020

Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential?

1 reference

12 December 2020

The neurobiology and control of anxious states

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12 December 2020

Effect of chronic administration of selective 5-hydroxytryptamine and noradrenaline uptake inhibitors on a putative index of 5-HT2C/2B receptor function

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12 December 2020

In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism

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12 December 2020

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12 December 2020

Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application

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12 December 2020

5-Hydroxytryptamine2C receptors on spinal neurons controlling penile erection in the rat.

1 reference

12 December 2020

Efficacy of agomelatine, a MT1/MT2 receptor agonist with 5-HT2C antagonistic properties, in major depressive disorder

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12 December 2020

S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: II. Modulation of hippocampal serotonin release in relation to potential anxiolytic properties.

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12 December 2020

Involvement of 5-HT(2C) receptors in the anti-immobility effects of antidepressants in the forced swimming test in mice

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12 December 2020

Citalopram reduces social interaction in rats by activation of serotonin (5-HT)(2C) receptors

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12 December 2020

Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505

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12 December 2020

Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment

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12 December 2020

H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

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12 December 2020

Bi-phasic change in BDNF gene expression following antidepressant drug treatment

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12 December 2020

Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system

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12 December 2020

Serotonin 5-ht2 receptors: molecular and genomic diversity

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12 December 2020

Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike?

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12 December 2020

Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone

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12 December 2020

Catecholaminergic strategies for the treatment of major depression

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12 December 2020

Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice

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12 December 2020

Influence of the 5-HT2C receptor antagonist, SB-242084, in tests of anxiety

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12 December 2020

Discriminative stimulus properties of the novel serotonin (5-HT)2C receptor agonist, RO 60-0175: a pharmacological analysis.

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12 December 2020

Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS.

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12 December 2020

Serotonin 5-HT(2C) receptors regulate anxiety-like behavior

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12 December 2020

Possible serotonergic mechanisms underlying the antidepressant and anti-obsessive-compulsive disorder responses

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12 December 2020

Ritanserin, imipramine, and placebo in the treatment of dysthymic disorder

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12 December 2020

Acute administration of the novel serotonin and noradrenaline reuptake inhibitor, S33005, markedly modifies sleep-wake cycle architecture in the rat.

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12 December 2020

Differential activation of Gq/11 and Gi(3) proteins at 5-hydroxytryptamine(2C) receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking

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12 December 2020

Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors

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12 December 2020

5-HT2A and 5-HT2C receptors and their atypical regulation properties

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12 December 2020

Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction

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12 December 2020

Effect of agomelatine in the chronic mild stress model of depression in the rat.

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12 December 2020

WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity

1 reference

12 December 2020

A comparative study of the effects of selective and non-selective 5-HT2 receptor subtype antagonists in rat and mouse models of anxiety.

1 reference

12 December 2020

A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants

1 reference

12 December 2020

Conditioned ultrasonic distress vocalizations in adult male rats as a behavioural paradigm for screening anti-panic drugs.

1 reference

12 December 2020

Functional consequence of serotonin/5-HT2B receptor signaling in heart: role of mitochondria in transition between hypertrophy and heart failure?

1 reference

12 December 2020

Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

1 reference

12 December 2020

Low versus standard dose mCPP challenge in obsessive-compulsive patients.

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12 December 2020

A review of 25 years of the social interaction test

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12 December 2020

Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes.

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12 December 2020

Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy

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12 December 2020

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

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12 December 2020

Role of neurotrophic factors in depression

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12 December 2020

Neurobiology and clinical pharmacology of obsessive-compulsive disorder

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12 December 2020

Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors

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12 December 2020

5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists

1 reference

12 December 2020

WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activity

1 reference

12 December 2020

Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat

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12 December 2020

Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents

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12 December 2020

Effects of repeated mild stress and two antidepressant treatments on the behavioral response to 5HT1C receptor activation in rats

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12 December 2020

CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity

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12 December 2020

Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers

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12 December 2020

Anxiogenic effects in the rat elevated plus-maze of 5-HT(2C) agonists into ventral but not dorsal hippocampus.

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12 December 2020

Effect of SB-243213, a selective 5-HT(2C) receptor antagonist, on the rat sleep profile: a comparison to paroxetine

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12 December 2020

Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors

1 reference

12 December 2020

Effects of RO 60 0175, a 5-HT(2C) receptor agonist, in three animal models of anxiety.

1 reference

12 December 2020

Evidence for accelerated desensitisation of 5-HT(2C) receptors following combined treatment with fluoxetine and the 5-HT(1A) receptor antagonist, WAY 100,635, in the rat

1 reference

12 December 2020

Long-term side effects of SSRIs: sexual dysfunction and weight gain.

1 reference

12 December 2020

Intruder-evoked aggression in isolated and nonisolated mice: Effects of psychomotor stimulants and l-Dopa

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12 December 2020

Effects of centrally administered anxiolytic compounds in animal models of anxiety

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12 December 2020

Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies.

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12 December 2020

Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats

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12 December 2020

5-HT(2C) receptor activation inhibits appetitive and consummatory components of feeding and increases brain c-fos immunoreactivity in mice.

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12 December 2020

Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety

1 reference

12 December 2020

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

1 reference

12 December 2020

Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study

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12 December 2020

Increased 5-HT2C receptor responsiveness occurs on rearing rats in social isolation

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12 December 2020

A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study.

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12 December 2020

SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist

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12 December 2020

The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways

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12 December 2020

Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635.

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12 December 2020

Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry.

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12 December 2020

Induction of hyperlocomotion in mice exposed to a novel environment by inhibition of serotonin reuptake. A pharmacological characterization of diverse classes of antidepressant agents

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12 December 2020

10.1007/S00213-008-1177-9

Identifiers

DOI

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Dimensions Publication ID

4 August 2017

1001136723

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