Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma (Q34786512)

25431954

4 August 2017

title

Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma (English)

1 reference

25431954

4 August 2017

main subject

hepatocellular carcinoma

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431954%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Matteo Ravaioli

6

1 reference

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9 June 2020

author name string

Catia Giovannini

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431954%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Manuela Minguzzi

2

1 reference

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9 June 2020

Michele Baglioni

3

1 reference

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9 June 2020

Ferdinando Giannone

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431954%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Matteo Cescon

7

1 reference

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9 June 2020

Pasquale Chieco

8

1 reference

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9 June 2020

Luigi Bolondi

9

1 reference

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9 June 2020

Laura Gramantieri

10

1 reference

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9 June 2020

language of work or name

English

0 references

publication date

1 November 2014

1 reference

4 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431954%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

5

1 reference

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9 June 2020

issue

21

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9 June 2020

page(s)

10607-10620

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431954%20AND%20SRC:MED&resulttype=core&format=json

p53/mdm2 feedback loop sustains miR-221 expression and dictates the response to anticancer treatments in hepatocellular carcinoma

9 June 2020

cites work

1 reference

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Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3b phosphorylation and p21 down-regulation in hepatocellular carcinoma

8 July 2018

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Notch inhibitors for cancer treatment

8 July 2018

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CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma

8 July 2018

1 reference

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MDM-2 antagonists induce p53-dependent cell cycle arrest but not cell death in renal cancer cell lines

8 July 2018

1 reference

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MicroRNA-221 regulates chondrogenic differentiation through promoting proteosomal degradation of slug by targeting Mdm2

8 July 2018

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MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells

8 July 2018

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Regulation of XIAP translation and induction by MDM2 following irradiation

8 July 2018

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Selective ablation of Notch3 in HCC enhances doxorubicin's death promoting effect by a p53 dependent mechanism

8 July 2018

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Substrate specificity of gamma-secretase and other intramembrane proteases

8 July 2018

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Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma

8 July 2018

1 reference

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Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279397

MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 is activated in response to inhibited Akt signaling

8 July 2018

1 reference

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Notch3 intracellular domain accumulates in HepG2 cell line

8 July 2018

1 reference

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p53 ubiquitination: Mdm2 and beyond

8 July 2018

1 reference

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Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279397

p53-independent functions of MDM2.

8 July 2018

1 reference

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HES and HERP families: multiple effectors of the Notch signaling pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279397

Cyclin G recruits PP2A to dephosphorylate Mdm2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279397

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279397

Cyclin a-CDK phosphorylation regulates MDM2 protein interactions

8 July 2018

1 reference

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RNA interference is mediated by 21- and 22-nucleotide RNAs

8 July 2018

1 reference

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8 July 2018

Surfing the p53 network

1 reference

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

8 July 2018

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

8 July 2018

1 reference

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Mdm2 promotes the rapid degradation of p53

8 July 2018

1 reference

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

8 July 2018

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Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1

8 July 2018

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The p53-mdm-2 autoregulatory feedback loop

8 July 2018

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Cyclin G is a transcriptional target of the p53 tumor suppressor protein

8 July 2018

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Liver Carcinogenesis by Diethylnitrosamine in the Rat

8 July 2018

1 reference

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In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2.

8 July 2018

1 reference

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HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding.

26 October 2018

1 reference

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Characterizing the role of MDM2 in diethylnitrosamine induced acute liver damage and development of pre-neoplastic lesions

26 October 2018

1 reference

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Reduced hepatic tumor incidence in cyclin G1-deficient mice

26 October 2018

1 reference

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p53-independent cyclin G expression in a group of mature neurons and its enhanced expression during nerve regeneration.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4279397

Crosstalk of Notch with p53 and p63 in cancer growth control

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25431954

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25431954

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.2523

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431954%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431954%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

25431954

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25431954%20AND%20SRC:MED&resulttype=core&format=json