Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice (Q34791274)

25043591

4 August 2017

title

Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice (English)

1 reference

4 August 2017

0 references

5

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13 June 2020

Florent Elefteriou

9

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13 June 2020

7

Jeffry S Nyman

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13 June 2020

author name string

Jean de la Croix Ndong

1

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13 June 2020

David M Stevens

2

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13 June 2020

Guillaume Vignaux

3

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13 June 2020

Sasidhar Uppuganti

4

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13 June 2020

Xiangli Yang

6

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13 June 2020

Eva Harth

8

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13 June 2020

publication date

1 January 2015

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25043591

Journal of Bone and Mineral Research

4 August 2017

published in

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13 June 2020

volume

30

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13 June 2020

issue

1

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13 June 2020

page(s)

55-63

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Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1.

13 June 2020

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The ras-GTPase activity of neurofibromin restrains ERK-dependent FGFR signaling during endochondral bone formation.

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8 July 2018

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Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh.

8 July 2018

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Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia

8 July 2018

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Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate

8 July 2018

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Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I.

8 July 2018

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Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo

8 July 2018

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Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.

8 July 2018

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Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts.

8 July 2018

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Are endogenous BMPs necessary for bone healing during distraction osteogenesis?

8 July 2018

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TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation

8 July 2018

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Modelling neurofibromatosis type 1 tibial dysplasia and its treatment with lovastatin

8 July 2018

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Scoliosis associated with neurofibromatosis

8 July 2018

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ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae

8 July 2018

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Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix

8 July 2018

1 reference

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Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

8 July 2018

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Chemotherapy for hepatoblastoma in children

8 July 2018

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Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model.

8 July 2018

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Treatment of a congenital pseudarthrosis of the tibia by osteogenic protein-1 (bone morphogenetic protein-7): a case report.

21 January 2018

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Bone morphogenetic protein 7 in the treatment of congenital pseudarthrosis of the tibia.

21 January 2018

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Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors

21 January 2018

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Controlled branching of polyglycidol and formation of protein-glycidol bioconjugates via a graft-from approach with "PEG-like" arms

21 January 2018

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Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient mice

21 January 2018

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Congenital pseudarthrosis of neurofibromatosis type 1: impaired osteoblast differentiation and function and altered NF1 gene expression

21 January 2018

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Multiple roles for neurofibromin in skeletal development and growth

21 January 2018

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MR imaging of spinal tumors in children with neurofibromatosis 1

21 January 2018

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12 December 2020

Modeling bone morphogenetic protein and bisphosphonate combination therapy in wild-type and Nf1 haploinsufficient mice

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12 December 2020

BMP4 Is Dispensable for Skeletogenesis and Fracture-Healing in the Limb

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12 December 2020

Whole-spine magnetic resonance imaging in patients with neurofibromatosis type 1 and spinal deformity

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12 December 2020

Treatment of congenital pseudarthrosis of the tibia with recombinant human bone morphogenetic protein-7 (rhBMP-7). A report of five cases

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12 December 2020

Identifiers

DOI

10.1002/JBMR.2316

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13 June 2020

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13 June 2020

25043591

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