PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium (Q34796595)

4 August 2017

title

PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium (English)

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4 August 2017

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5

Derek LeRoith

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4 August 2017

Joëlle Dupont

1

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4 August 2017

Jean Pierre Renou

series ordinal

2

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4 August 2017

Moshe Shani

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3

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4 August 2017

Lothar Hennighausen

series ordinal

4

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4 August 2017

language of work or name

English

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publication date

1 September 2002

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Journal of Clinical Investigation

4 August 2017

published in

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4 August 2017

volume

110

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4 August 2017

issue

6

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4 August 2017

page(s)

815-825

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Initiating oncogenic event determines gene-expression patterns of human breast cancer models

4 August 2017

cites work

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8 July 2018

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8 July 2018

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PTEN and myotubularin: novel phosphoinositide phosphatases

8 July 2018

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Growth defects induced by perturbation of beta1-integrin function in the mammary gland epithelium result from a lack of MAPK activation via the Shc and Akt pathways

8 July 2018

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Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

8 July 2018

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PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

8 July 2018

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PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor

8 July 2018

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Effect of PRL on MAPK activation: negative regulatory role of the C-terminal part of the PRL receptor

8 July 2018

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PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

8 July 2018

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Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

8 July 2018

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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

8 July 2018

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8 July 2018

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Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

8 July 2018

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Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

8 July 2018

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

8 July 2018

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Expression of ovine insulin-like growth factor-1 (IGF-1) stimulates alveolar bud development in mammary glands of transgenic mice

8 July 2018

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The C/EBPbeta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland

8 July 2018

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Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct development.

8 July 2018

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8 July 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

8 July 2018

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Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model

8 July 2018

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Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression

8 July 2018

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Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities

8 July 2018

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Insulin-like growth factor-binding protein enhancement of insulin-like growth factor-I (IGF-I)-mediated DNA synthesis and IGF-I binding in a human breast carcinoma cell line

8 July 2018

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Growth factors in mammary gland function

8 July 2018

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Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation.

8 July 2018

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Complement 3 deficiency and oral prednisolone improve strength and prolong survival of laminin alpha2-deficient mice

8 July 2018

1 reference

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Mammary gland involution is delayed by activated Akt in transgenic mice.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151121

Induction of mammary gland hyperplasia in transgenic mice over-expressing human Cdc25B.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151121

Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151121

The high mobility group protein, HMGI-C.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151121

Nutritional state regulates insulin receptor and IRS-1 phosphorylation and expression in chicken.

26 October 2018

1 reference

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Think globally, act locally: the making of a mouse mammary gland.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151121

Inhibition of IGFBP-5 binding to extracellular matrix and IGF-I-stimulated DNA synthesis by a peptide fragment of IGFBP-5

26 October 2018

1 reference

12 December 2020

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

1 reference

12 December 2020

Mechanically induced electrical responses in murine mammary epithelial cells in primary culture

1 reference

12 December 2020

The hormonal control of mammary growth and lactation

1 reference

12 December 2020

MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival

1 reference

12 December 2020

Impaired Fas response and autoimmunity in Pten+/- mice

1 reference

12 December 2020

Prolactin (PRL)-PRL receptor system increases cell proliferation involving JNK (c-Jun amino terminal kinase) and AP-1 activation: inhibition by glucocorticoids

1 reference

12 December 2020

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI0213829

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4 August 2017

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4 August 2017

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