Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector. (Q34797039)

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10 January 2020

title

Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector (English)

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10 January 2020

3

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10 January 2020

Simon N. Waddington

4

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author name string

O Argyros

1

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10 January 2020

S P Wong

2

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10 January 2020

S J Howe

5

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10 January 2020

C Coutelle

6

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A D Miller

7

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R P Harbottle

8

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10 January 2020

publication date

17 July 2008

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10 January 2020

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10 January 2020

volume

15

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issue

24

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10 January 2020

page(s)

1593-1605

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A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

10 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Progress and problems with the use of viral vectors for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Quantitative bioluminescence imaging of transgene expression in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Dynamic gene expression after systemic delivery of plasmid DNA as determined by in vivo bioluminescence imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

In vitro and in vivo comparative study of chimeric liver-specific promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Interferons inhibit onset of murine cytomegalovirus immediate-early gene transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Optimization of cis-acting elements for gene expression from nonviral vectors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

An araC-controlled bacterial cre expression system to produce DNA minicircle vectors for nuclear and mitochondrial gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Improved production and purification of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Minicircle: an improved DNA molecule for in vitro and in vivo gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Designing nonviral vectors for efficient gene transfer and long-term gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Epstein-Barr virus/human vector provides high-level, long-term expression of alpha1-antitrypsin in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

An S/MAR-based infectious episomal genomic DNA expression vector provides long-term regulated functional complementation of LDLR deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Expression of a transgene encoded on a non-viral episomal vector is not subject to epigenetic silencing by cytosine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

An episomally replicating vector binds to the nuclear matrix protein SAF-A in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying an S/MAR element

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Localization and dynamics of small circular DNA in live mammalian nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

SAF-Box, a conserved protein domain that specifically recognizes scaffold attachment region DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Genetically modified pigs produced with a nonviral episomal vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Exploiting a minimal system to study the epigenetic control of DNA replication: the interplay between transcription and replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Long-term and therapeutic-level hepatic gene expression of human factor IX after naked plasmid transfer in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Establishment and mitotic stability of an extra-chromosomal mammalian replicon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Translating the Histone Code

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

DNA methylation and histone modifications: teaming up to silence genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Histone modifications are associated with the persistence or silencing of vector-mediated transgene expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

DNA methylation represses transcription in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Methylation of episomal plasmids as a barrier to transient gene expression via a synthetic delivery vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Stem cell-derived erythroid cells mediate long-term systemic protein delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Muscle-specific promoters may be necessary for adeno-associated virus-mediated gene transfer in the treatment of muscular dystrophies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Variables affecting in vivo performance of high-capacity adenovirus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Gene therapy progress and prospects: episomally maintained self-replicating systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Gene silencing in mammalian cells and the spread of DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

Scaffold/matrix-attached regions act upon transcription in a context-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

The nonviral episomal replicating vector pEPI-1 allows long-term inhibition of bcr-abl expression by shRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

A lentiviral vector encoding the human Wiskott-Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113

inferred from DOI database lookup

7 January 2021

based on heuristic

A distinct sequence (ATAAA)n separates methylated and unmethylated domains at the 5'-end of the GSTP1 CpG island

1 reference

https://api.crossref.org/works/10.1038%2FGT.2008.113