Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options (Q34800437)

4 August 2017

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title

Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options (English)

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4 August 2017

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Paul J Thornalley

1

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4 August 2017

1 January 2002

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International Review of Neurobiology

4 August 2017

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4 August 2017

50

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4 August 2017

37-57

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Accumulation of alpha-oxoaldehydes during oxidative stress: a role in cytotoxicity

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

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https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Relationship between glycemic control and collagen-linked advanced glycosylation end products in type I diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Functional and structural abnormalities in the nerves of type I diabetic baboons: aminoguanidine treatment does not improve nerve function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Effects of aminoguanidine on peripheral nerve function and polyol pathway metabolites in streptozotocin-diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Hydroperoxide metabolism in mammalian organs

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https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Glycation of rat sciatic nerve tubulin in experimental diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Aminoguanidine inhibits albuminuria, but not the formation of advanced glycation end-products in skin collagen of diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

The carbohydrate moiety in hemoglobin A1C is present in the ring form

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Retention of subunits of the oligosaccharyltransferase complex in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Tests of glycemia in diabetes

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https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

In vivo expression and localization of the fibroblast growth factor system in the intact and lesioned rat peripheral nerve and spinal ganglia.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Antibacterial activity of lysozyme and lactoferrin is inhibited by binding of advanced glycation-modified proteins to a conserved motif.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Glucose transporters in rat peripheral nerve: Paranodal expression of GLUT1 and GLUT3

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

cDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Posttranslational modifications of nerve cytoskeletal proteins in experimental diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT S

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Human serum albumin minimally modified by methylglyoxal binds to human mononuclear leukocytes via the RAGE receptor and is displaced by Nε-carboxymethyl-lysine and hydroimidazolone AGE epitopes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Cd36, a member of the class b scavenger receptor family, as a receptor for advanced glycation end products

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Increased endoneurial albumin in diabetic polyneuropathy

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

The effect of non-enzymatic glycation of serum proteins on their permeation into peripheral nerve in normal and streptozotocin-diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Murine microglial cells express functionally active galectin-3 in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Recombinant advanced glycation end product receptor pharmacokinetics in normal and diabetic rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

The O2- -forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Non-enzymatic glycation of peripheral nerve proteins in human diabetics

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Nonenzymatic glycation of peripheral and central nervous system proteins in experimental diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Blood thiamine levels in outpatients with diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Improved metabolic control in patients with non-insulin-dependent diabetes mellitus is associated with a slower accumulation of glycation products in collagen.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Reduction of advanced glycation end-product (AGE) levels in nervous tissue proteins of diabetic Lewis rats following islet transplants is related to different durations of poor metabolic control

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Mechanism of the degradation of non-enzymatically glycated proteins under physiological conditions. Studies with the model fructosamine, N epsilon-(1-deoxy-D-fructos-1-yl)hippuryl-lysine.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Localization in human diabetic peripheral nerve of N(epsilon)-carboxymethyllysine-protein adducts, an advanced glycation endproduct

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Effects of aminoguanidine on structural alterations of microvessels in peripheral nerve of streptozotocin diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Modification of the glyoxalase system in human red blood cells by glucose in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Kinetics and mechanism of the reaction of aminoguanidine with the alpha-oxoaldehydes glyoxal, methylglyoxal, and 3-deoxyglucosone under physiological conditions.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Effect of collagen turnover on the accumulation of advanced glycation end products

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Only limited effects of aminoguanidine treatment on peripheral nerve function, (Na+,K+)-ATPase activity and thrombomodulin expression in streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Pyridine nucleotides in glucose metabolism and diabetes: a review

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Molecular characteristics of methylglyoxal-modified bovine and human serum albumins. Comparison with glucose-derived advanced glycation endproduct-modified serum albumins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

Aminoguanidine inhibits semicarbazide-sensitive amine oxidase activity: implications for advanced glycation and diabetic complications

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2950072-6

7 January 2021

10.1016/S0074-7742(02)50072-6

Identifiers

DOI

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4 August 2017

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PubMed ID

12198817