Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease (Q34802038)

4 August 2017

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title

Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease (English)

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4 August 2017

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Makoto Naoi

1

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4 August 2017

Wakako Maruyama

series ordinal

2

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4 August 2017

Yukihiro Akao

series ordinal

3

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4 August 2017

Hong Yi

series ordinal

4

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4 August 2017

publication date

1 September 2002

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Neurotoxicology and Teratology

4 August 2017

published in

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4 August 2017

volume

24

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4 August 2017

issue

5

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4 August 2017

page(s)

579-591

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Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3.

4 August 2017

cites work

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Beta-carboline analogues of N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP): endogenous factors underlying idiopathic parkinsonism?

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7 January 2021

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

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7 January 2021

Biosynthesis of salsolinol, a tetrahydroisoquinoline alkaloid, in healthy subjects

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7 January 2021

Ageing and Parkinson's disease: substantia nigra regional selectivity

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7 January 2021

Neurotoxic effects of papaverine, tetrahydropapaverine and dimethoxyphenylethylamine on dopaminergic neurons in ventral mesencephalic-striatal co-culture

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7 January 2021

Mitochondria and apoptosis

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7 January 2021

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

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7 January 2021

Formation of Tetrahydropapaveroline from Dopamine in vitro

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7 January 2021

Programmed cell death in animal development

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7 January 2021

Aging produces a specific pattern of striatal dopamine loss: implications for the etiology of idiopathic Parkinson's disease

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7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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7 January 2021

Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system

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7 January 2021

The mitochondrial death/life regulator in apoptosis and necrosis

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7 January 2021

1,2,3,4-Tetrahydro-2-methyl-4,6,7-isoquinolinetriol depletes catecholamines in rat brain

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7 January 2021

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7 January 2021

N-methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: in vivo microdialysis study

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7 January 2021

Inhibition of tyrosine hydroxylase by a dopamine neurotoxin, 1-methyl-4-phenylpyridinium ion: depletion of allostery to the biopterin cofactor

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7 January 2021

Dopamine-derived 1-methyl-6,7-dihydroxyisoquinolines as hydroxyl radical promoters and scavengers in the rat brain: in vivo and in vitro studies

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7 January 2021

N-methyl(r)salsolinol produces hydroxyl radicals: Involvement to neurotoxicity

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7 January 2021

A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in parkinsonian cerebrospinal fluid

1 reference

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7 January 2021

Stereospecific occurrence of a parkinsonism-inducing catechol isoquinoline, N-methyl(R)salsolinol, in the human intraventricular fluid

1 reference

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7 January 2021

An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigro-striatal system of the human brai

1 reference

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7 January 2021

A neurotoxin N-methyl(R)salsolinol induces apoptotic cell death in differentiated human dopaminergic neuroblastoma SH-SY5Y cells

1 reference

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7 January 2021

Dopaminergic neurotoxins, 6,7-dihydroxy-1-(3', 4'-dihydroxybenzyl)-isoquinolines, cause different types of cell death in SH-SY5Y cells: apoptosis was induced by oxidized papaverolines and necrosis by reduced tetrahydropapaverolines

1 reference

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7 January 2021

Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine

1 reference

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7 January 2021

Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol

1 reference

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7 January 2021

Glyceraldehyde-3-phospate dehydrogenase is translocated into nuclei through Golgi apparatus during apoptosis induced by 6-hydroxydopamine in human dopaminergic SH-SY5Y cells

1 reference

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7 January 2021

Rate of cell death in parkinsonism indicates active neuropathological process

1 reference

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7 January 2021

Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat.

1 reference

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7 January 2021

Histochemical detection of apoptosis in Parkinson's disease.

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7 January 2021

Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes

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7 January 2021

Presence of N-methyl-norsalsolinol in the CSF: correlations with dopamine metabolites of patients with Parkinson's disease

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7 January 2021

Plasma levels of R- and S-salsolinol are not increased in "de-novo" Parkinsonian patients.

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7 January 2021

R- and S-salsolinol are not increased in cerebrospinal fluid of Parkinsonian patients

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7 January 2021

1-Methyl-4-phenylpyridinum kills differentiated PC12 cells with a concomitant change in protein phosphorylation

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7 January 2021

An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions

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7 January 2021

Binding of 1,2(N)-dimethyl-6,7-dihydroxy-isoquinolinium ion to melanin: effects of ferrous and ferric ion on the binding

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7 January 2021

Enzymatic oxidation of the dopaminergic neurotoxin, 1 (R), 2(N)-Dimethyl-6,7-Dihydroxy-l,2,3,4-Tetrahydroisoquinoline, into 1,2(N)-Dimethyl-6,7-Dihydroxyisoquinolinium ion

1 reference

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7 January 2021

Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies.

1 reference

https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol.

1 reference

https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

A neutral N-methyltransferase activity in the striatum determines the level of an endogenous MPP+-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains

1 reference

https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

(R)salsolinol N-methyltransferase activity increases in parkinsonian lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopamine neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

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https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

Tetrahydroisoquinoline alkaloids: in vivo metabolites of L-dopa in man.

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7 January 2021

Enantio-selective occurrence of (S)-tetrahydropapaveroline in human brain

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7 January 2021

Ratio of the R and S enantiomers of salsolinol in food and human urine

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https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system

1 reference

https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

Apoptosis in the pathogenesis and treatment of disease

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7 January 2021

Caspases: enemies within

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7 January 2021

Bcl-2 family: life-or-death switch

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7 January 2021

VDAC regulation by the Bcl-2 family of proteins

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7 January 2021

Neurotoxicity of 1,2,3,4-tetrahydro-2-methyl-4,6,7-isoquinolinetriol (TMIQ) and effects on catecholamine homeostasis in SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1016%2FS0892-0362%2802%2900211-8

7 January 2021

10.1016/S0892-0362(02)00211-8

Identifiers

DOI

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4 August 2017

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