The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models. (Q34802502)

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English	The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models.	scientific article

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21 February 2020

The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models (English)

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21 February 2020

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Hodgkin lymphoma

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inferred from title

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8

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21 February 2020

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Dashnamoorthy Ravi

1

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21 February 2020

Savita Bhalla

2

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21 February 2020

Ronald B Gartenhaus

3

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21 February 2020

Jennifer Crombie

4

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21 February 2020

Irawati Kandela

5

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21 February 2020

Jaya Sharma

6

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21 February 2020

Andrew Mazar

7

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21 February 2020

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14 October 2014

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21 February 2020

Clinical Cancer Research

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21 February 2020

20

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21 February 2020

23

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21 February 2020

6023-6033

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21 February 2020

PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas

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8 July 2018

ERK1/2 MAP kinases: structure, function, and regulation

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8 July 2018

Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer

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8 July 2018

Regulation of proliferation, survival, differentiation, and activation by the Signaling Platform for SHP-1 phosphatase.

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8 July 2018

14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis

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8 July 2018

An anti-urokinase plasminogen activator receptor antibody (ATN-658) blocks prostate cancer invasion, migration, growth, and experimental skeletal metastasis in vitro and in vivo.

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8 July 2018

Phosphoinositide signalling in cancer: beyond PI3K and PTEN.

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8 July 2018

Role of redox signaling, protein phosphatases and histone acetylation in the inflammatory cascade in acute pancreatitis. Therapeutic implications.

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8 July 2018

Extracellular signal-regulated kinase positively regulates the oncogenic activity of MCT-1 in diffuse large B-cell lymphoma

1 reference

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8 July 2018

SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis.

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8 July 2018

Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281835

8 July 2018

A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281835

8 July 2018

The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281835

8 July 2018

Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281835

8 July 2018

Cytotoxic effects of S-(dimethylarsino)-glutathione: a putative intermediate metabolite of inorganic arsenicals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281835

8 July 2018

T-cell non-Hodgkin lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281835

8 July 2018

Phosphoinositide 3-kinase/Akt inhibition increases arsenic trioxide-induced apoptosis of acute promyelocytic and T-cell leukaemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4281835

8 July 2018

Beyond single pathway inhibition: MEK inhibitors as a platform for the development of pharmacological combinations with synergistic anti-leukemic effects

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8 July 2018

Phase II trial of arsenic trioxide and alpha interferon in patients with relapsed/refractory adult T-cell leukemia/lymphoma

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8 July 2018

History of the development of arsenic derivatives in cancer therapy

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8 July 2018

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

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8 July 2018

Monitoring Response and Resistance to the Novel Arsenical Darinaparsin in an AML Patient

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26 October 2018

Deficiency of SHP1 leads to sustained and increased ERK activation in mast cells, thereby inhibiting IL-3-dependent proliferation and cell death

1 reference

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26 October 2018

Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation.

1 reference

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26 October 2018

A phase I clinical trial of darinaparsin in patients with refractory solid tumors.

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26 October 2018

Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways.

1 reference

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26 October 2018

In vitro activity of dimethylarsinic acid against human leukemia and multiple myeloma cell lines

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26 October 2018

Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.

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26 October 2018

A multicenter phase II study of darinaparsin in relapsed or refractory Hodgkin's and non-Hodgkin's lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25316819

12 December 2020

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10.1158/1078-0432.CCR-14-1532

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21 February 2020

PMC publication ID

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21 February 2020

PubMed publication ID

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Europe PubMed Central

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21 February 2020

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