Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model. (Q34803897)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25587392%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

title

Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model (English)

1 reference

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27 February 2020

1 reference

8

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27 February 2020

5

Wayne J Hawthorne

1 reference

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27 February 2020

7

Robyn M Sutherland

1 reference

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27 February 2020

author name string

Jamie L Brady

1

1 reference

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27 February 2020

Leonard C Harrison

2

1 reference

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27 February 2020

David J Goodman

3

1 reference

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27 February 2020

Peter J Cowan

4

1 reference

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27 February 2020

Philip J O'Connell

6

1 reference

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27 February 2020

publication date

19 December 2014

1 reference

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Clinical & translational immunology

27 February 2020

published in

1 reference

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27 February 2020

volume

3

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27 February 2020

page(s)

e29

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issue

12

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Humanized mice as a model for aberrant responses in human T cell immunotherapy.

27 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Pharmacokinetics and brain uptake of an IgG-TNF decoy receptor fusion protein following intravenous, intraperitoneal, and subcutaneous administration in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Humanized mice for immune system investigation: progress, promise and challenges

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Monoclonal antibody-induced cytokine-release syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

The safety and side effects of monoclonal antibodies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Dose translation from animal to human studies revisited

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Rabbit antithymocyte globulin induction therapy in adult renal transplantation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Interactions of immunoglobulins outside the antigen-combining site

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Campath-1H (anti-CD52) monoclonal antibody therapy in lymphoproliferative disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Muromonab CD3: a reappraisal of its pharmacology and use as prophylaxis of solid organ transplant rejection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

In vivo cell activation following OKT3 administration. Systemic cytokine release and modulation by corticosteroids

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Human antibody effector function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model

8 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FCTI.2014.28

Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCTI.2014.28

Breakthrough of the year 2013. Cancer immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCTI.2014.28

Adverse events to monoclonal antibodies used for cancer therapy: Focus on hypersensitivity responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCTI.2014.28

21 January 2018

Lessons from TGN1412.

1 reference

https://api.crossref.org/works/10.1038%2FCTI.2014.28

Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Preclinical efficacy and immunological safety of FR104, an antagonist anti-CD28 monovalent Fab' antibody

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4282178

Ex-vivo whole blood cultures for predicting cytokine-release syndrome: dependence on target antigen and antibody isotype

26 October 2018

1 reference

12 December 2020

Development of a human whole blood assay for prediction of cytokine release similar to anti-CD28 superagonists using multiplex cytokine and hierarchical cluster analysis

1 reference

12 December 2020

Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412

1 reference

12 December 2020

Cytokine release syndrome induced by the 145-2C11 anti-CD3 monoclonal antibody in mice: prevention by high doses of methylprednisolone

1 reference

12 December 2020

"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics

1 reference

12 December 2020

Identifiers

DOI

10.1038/CTI.2014.28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25587392%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25587392%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

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