The safety and side effects of monoclonal antibodies (Q37715703)

22 August 2017

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title

The safety and side effects of monoclonal antibodies (English)

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22 August 2017

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1

Trevor T Hansel

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22 August 2017

Harald Kropshofer

2

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22 August 2017

Thomas Singer

series ordinal

3

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22 August 2017

Jane A Mitchell

series ordinal

4

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22 August 2017

Andrew J T George

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5

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22 August 2017

22 March 2010

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Nature Reviews Drug Discovery

22 August 2017

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22 August 2017

9

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22 August 2017

325-338

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22 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrd3003

22 August 2017

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The utility of monoclonal antibody therapy in renal transplantation

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OKT3 first-dose reaction: association with T cell subsets and cytokine release

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Molecular, biologic, and pharmacokinetic properties of monoclonal antibodies: impact of these parameters on early clinical development

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Risk and case characteristics of tuberculosis in rheumatoid arthritis associated with tumor necrosis factor antagonists in Sweden

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Anti-tumor necrosis factor alpha therapy and the risk of serious bacterial infections in elderly patients with rheumatoid arthritis

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Review article: minimizing tuberculosis during anti-tumour necrosis factor-alpha treatment of inflammatory bowel disease

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The safety profile of infliximab in patients with Crohn's disease: the Mayo clinic experience in 500 patients

31 March 2020

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BTS recommendations for assessing risk and for managing Mycobacterium tuberculosis infection and disease in patients due to start anti-TNF-alpha treatment

31 March 2020

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Progressive multifocal leukoencephalopathy in patients on immunomodulatory therapies

31 March 2020

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Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project

31 March 2020

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Novel therapeutic strategies for multiple sclerosis--a multifaceted adversary

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Progressive multifocal leukoencephalopathy after natalizumab monotherapy.

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Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy

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Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring

31 March 2020

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Natalizumab and PML: a risky business?

31 March 2020

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False negative PCR despite high levels of JC virus DNA in spinal fluid: Implications for diagnostic testing

31 March 2020

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Asymptomatic reactivation of JC virus in patients treated with natalizumab

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Application of molecular tools for the diagnosis of central nervous system infections

31 March 2020

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Therapy: Targeted but not trouble-free: efalizumab and PML

31 March 2020

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Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab.

31 March 2020

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The monoclonal anti-VLA-4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans

31 March 2020

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31 March 2020

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Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project

31 March 2020

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Drug-induced immune thrombocytopenia

31 March 2020

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Platelet GPIIb-IIIa blockers

31 March 2020

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Abciximab readministration: results of the ReoPro Readministration Registry

31 March 2020

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Multi-year follow-up of abciximab therapy in three randomized, placebo-controlled trials of percutaneous coronary revascularization

31 March 2020

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The chimeric monoclonal antibody abciximab: a systematic review of its safety in contemporary practice

31 March 2020

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Delayed thrombocytopenia after treatment with abciximab: a distinct clinical entity associated with the immune response to the drug.

31 March 2020

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Thrombocytopenia after second exposure to abciximab is caused by antibodies that recognize abciximab-coated platelets

31 March 2020

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31 March 2020

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31 March 2020

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CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Multiple lessons for multiple sclerosis

31 March 2020

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31 March 2020

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31 March 2020

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The effect of anti-CD40 ligand in immune thrombocytopenic purpura

31 March 2020

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31 March 2020

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Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

31 March 2020

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Platelet pro-aggregatory effects of CD40L monoclonal antibody.

31 March 2020

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The role of CD40 in CD40L- and antibody-mediated platelet activation

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31 March 2020

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31 March 2020

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Drug insight: autoimmune effects of medications-what's new?

31 March 2020

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Autoimmune Diseases Induced by TNF-Targeted Therapies

31 March 2020

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Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis

31 March 2020

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Anti-cytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment

31 March 2020

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Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade

31 March 2020

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Principles and use of anti-CTLA4 antibody in human cancer immunotherapy

31 March 2020

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Review: anti-CTLA-4 antibody ipilimumab: case studies of clinical response and immune-related adverse events

31 March 2020

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Is tumor immunity the same thing as autoimmunity? Implications for cancer immunotherapy

31 March 2020

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Malignancy and biologic therapy in rheumatoid arthritis

31 March 2020

1 reference

Tumor necrosis factor inhibitors for rheumatoid arthritis

31 March 2020

1 reference

Is there an association between anti-TNF monoclonal antibody therapy in rheumatoid arthritis and risk of malignancy and serious infection? Commentary on the meta-analysis by Bongartz et al

31 March 2020

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Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonists

31 March 2020

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Tumor necrosis factor alpha antagonist use and cancer in patients with rheumatoid arthritis

31 March 2020

1 reference

Treatment with biologic therapies and the risk of cancer in patients with IBD.

31 March 2020

1 reference

The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease

31 March 2020

1 reference

Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: a cautionary tale?

31 March 2020

1 reference

A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis

31 March 2020

1 reference

Current directions in IBD therapy: what goals are feasible with biological modifiers?

31 March 2020

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Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

31 March 2020

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Immunotherapy of cancer by IL-12-based cytokine combinations

31 March 2020

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IL-23 promotes tumour incidence and growth

31 March 2020

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Long-term responses in patients with recurring or refractory B-cell non-Hodgkin lymphoma treated with yttrium 90 ibritumomab tiuxetan

31 March 2020

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Epidermal growth factor receptor monoclonal antibodies for the treatment of metastatic colorectal cancer

31 March 2020

1 reference

Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?

31 March 2020

1 reference

Epidermal growth factor receptor inhibitor-related skin toxicity: mechanisms, treatment, and its potential role as a predictive marker

31 March 2020

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Correlation between rash and a positive drug response associated with bevacizumab in a patient with advanced colorectal cancer

31 March 2020

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Completeness in the reporting of dermatologic adverse drug reactions associated with monoclonal antibody epidermal growth factor receptor inhibitors in phase II and III colorectal cancer clinical trials

31 March 2020

1 reference

Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck

31 March 2020

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Randomized double-blind trial of prophylactic oral minocycline and topical tazarotene for cetuximab-associated acne-like eruption.

31 March 2020

1 reference

Trastuzumab--mechanism of action and use in clinical practice

31 March 2020

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Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition

31 March 2020

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Trastuzumab-induced cardiomyopathy.

31 March 2020

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Trastuzumab and cardiac dysfunction: update on preclinical studies

31 March 2020

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Herceptin and the heart--a molecular modifier of cardiac failure

31 March 2020

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Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer

31 March 2020

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Cardiotoxicity of the new cancer therapeutics--mechanisms of, and approaches to, the problem

31 March 2020

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Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics

31 March 2020

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ErbB2 is essential in the prevention of dilated cardiomyopathy.

31 March 2020

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Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes

31 March 2020

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Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy

31 March 2020

1 reference

The advent of the cytokine storm.

31 March 2020

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Monoclonal antibody first dose cytokine release syndromes-mechanisms and prediction

31 March 2020

1 reference

A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis

31 March 2020

1 reference

Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells

31 March 2020

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Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

31 March 2020

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Establishing risk of human experimentation with drugs: lessons from TGN1412.

31 March 2020

1 reference

The minimum anticipated biological effect level (MABEL) for selection of first human dose in clinical trials with monoclonal antibodies

31 March 2020

1 reference

Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis

31 March 2020

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CD28 superagonists: mode of action and therapeutic potential

31 March 2020

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A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats

31 March 2020

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Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies

31 March 2020

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CD28 superagonists: what makes the difference in humans?

31 March 2020

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T cell-directed therapies: lessons learned and future prospects

31 March 2020

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T-cell costimulation--biology, therapeutic potential, and challenges

31 March 2020

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Preparing for first-in-man studies: the challenges for translational immunology post-TGN1412.

31 March 2020

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The calm after the cytokine storm: lessons from the TGN1412 trial

31 March 2020

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31 March 2020

Lessons from TGN1412.

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31 March 2020

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Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies

31 March 2020

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Some aspects of the recombinantly expressed humanised superagonist anti-CD28 mAb, TGN1412 trial catastrophe lessons to safeguard mAbs and vaccine trials.

31 March 2020

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Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters

31 March 2020

1 reference

Humanized IgG1 and IgG4 anti-CD4 monoclonal antibodies: effects on lymphocytes in the blood, lymph nodes, and renal allografts in cynomolgus monkeys

31 March 2020

1 reference

A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing

31 March 2020

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Loss of Siglec expression on T lymphocytes during human evolution

31 March 2020

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A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans

31 March 2020

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Negative regulation of leucocyte functions by CD33-related siglecs

31 March 2020

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Siglecs and their roles in the immune system

31 March 2020

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Siglecs as positive and negative regulators of the immune system

31 March 2020

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Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice

31 March 2020

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Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome

31 March 2020

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Safety assessment and dose selection for first-in-human clinical trials with immunomodulatory monoclonal antibodies

31 March 2020

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The utility of microdosing over the past 5 years

31 March 2020

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Safety of phase I clinical trials with monoclonal antibodies in Germany--the regulatory requirements viewed in the aftermath of the TGN1412 disaster

31 March 2020

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Symposium report--development of safe protein therapeutics: pre-clinical, clinical and regulatory issues

31 March 2020

1 reference

"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics

31 March 2020

1 reference

Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412

31 March 2020

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Molecular imaging in drug development

31 March 2020

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Microscopic imaging techniques for drug discovery

31 March 2020

1 reference

Superagonistic anti-CD28 antibodies: potent activators of regulatory T cells for the therapy of autoimmune diseases

31 March 2020

1 reference

12 December 2020

Ex-vivo whole blood cultures for predicting cytokine-release syndrome: dependence on target antigen and antibody isotype

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12 December 2020

Serum sickness following treatment with rituximab.

1 reference

12 December 2020

Fatal delayed thrombocytopenia following abciximab therapy

1 reference

12 December 2020

Musculoskeletal manifestations and autoimmune diseases related to new biologic agents

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12 December 2020

Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8).

1 reference

12 December 2020

Developing antibodies for targeting immunoglobulin and membrane-bound immunoglobulin E.

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12 December 2020

Activation and increased expression of adhesion molecules on peripheral blood lymphocytes is a mechanism for the immediate lymphocytopenia after administration of OKT3

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12 December 2020

Cardiac toxicity of ErbB2-targeted therapies: what do we know?

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12 December 2020

Targeting the IgE molecule in allergic and asthmatic diseases: review of the IgE molecule and clinical efficacy

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12 December 2020

Will immunogenicity limit the use, efficacy, and future development of therapeutic monoclonal antibodies?

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12 December 2020

Neuregulin-1 and its potential role in the control of cardiac function

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12 December 2020

Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma.

1 reference

12 December 2020

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12 December 2020

Identifiers

DOI

10.1038/NRD3003

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Dimensions Publication ID

22 August 2017

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