Coeliac disease: dissecting a complex inflammatory disorder (Q34810240)

4 August 2017

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title

Coeliac disease: dissecting a complex inflammatory disorder (English)

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4 August 2017

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1

Ludvig M Sollid

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4 August 2017

1 September 2002

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Nature Reviews Immunology

4 August 2017

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4 August 2017

2

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4 August 2017

647-655

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4 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nri885

4 August 2017

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Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients

21 January 2018

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T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8.

21 January 2018

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The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) molecule

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Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease.

21 January 2018

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T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase

21 January 2018

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Measurement of gastrointestinal pH profiles in normal ambulant human subjects

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Autoantibodies in coeliac disease: tissue transglutaminase--guilt by association?

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Induction of tissue transglutaminase in human peripheral blood monocytes

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Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin

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Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin

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Profiling changes in gene expression during differentiation and maturation of monocyte-derived dendritic cells using both oligonucleotide microarrays and proteomics

21 January 2018

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High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue

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Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma

21 January 2018

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Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease

21 January 2018

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Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease

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Onset of coeliac disease during treatment with interferon for chronic hepatitis C.

21 January 2018

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Interferon-alpha drives T cell-mediated immunopathology in the intestine

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Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin

21 January 2018

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The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase

21 January 2018

1 reference

In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope.

21 January 2018

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The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides

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Proline specific peptidases

21 January 2018

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Amino-terminal trimming of peptides for presentation on major histocompatibility complex class II molecules

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Specificity of tissue transglutaminase explains cereal toxicity in celiac disease

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Superactivation of an immune response triggered by oligomerized T cell epitopes

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Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides

21 January 2018

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HLA binding and T cell recognition of a tissue transglutaminase-modified gliadin epitope

21 January 2018

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Oral tolerance: immune mechanisms and treatment of autoimmune diseases

21 January 2018

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Increase caused by interleukin-6 in promoter activity of guinea pig liver transglutaminase gene

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Man the barrier! Strategic defences in the intestinal mucosa

21 January 2018

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Post-translational protein modifications in antigen recognition and autoimmunity

21 January 2018

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Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies

21 January 2018

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The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin

21 January 2018

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T cell recognition of the dominant I-A(k)-restricted hen egg lysozyme epitope: critical role for asparagine deamidation

21 January 2018

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T cells from the peripheral blood of coeliac disease patients recognize gluten antigens when presented by HLA-DR, -DQ, or -DP molecules

21 January 2018

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Anergy induction by dimeric TCR ligands

21 January 2018

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21 January 2018

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Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

21 January 2018

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Existence of a genetic risk factor on chromosome 5q in Italian Coeliac Disease families

21 January 2018

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Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease

21 January 2018

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HLA-ABC and DR antigens in celiac disease. A study in a pediatric Italian population

31 March 2020

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CD28/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family-based association study

31 March 2020

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Linkage analysis of candidate regions for coeliac disease genes

31 March 2020

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A genome-wide family-based linkage study of coeliac disease

31 March 2020

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Genome-wide linkage analysis of Scandinavian affected sib-pairs supports presence of susceptibility loci for celiac disease on chromosomes 5 and 11

31 March 2020

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Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele

31 March 2020

1 reference

The IL12B gene does not confer susceptibility to coeliac disease

31 March 2020

1 reference

Gluten stimulation of coeliac mucosa in vitro induces activation (CD25) of lamina propria CD4+ T cells and macrophages but no crypt-cell hyperplasia

31 March 2020

1 reference

Identification of a putative motif for binding of peptides to HLA-DQ2

31 March 2020

1 reference

Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition

31 March 2020

1 reference

Human jejunal transglutaminase: demonstration of activity, enzyme kinetics and substrate specificity with special relation to gliadin and coeliac disease

31 March 2020

1 reference

Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease

31 March 2020

1 reference

Celiac disease during interferon treatment

31 March 2020

1 reference

Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells

31 March 2020

1 reference

Definition of the initial immunologic modifications upon in vitro gliadin challenge in the small intestine of celiac patients

31 March 2020

1 reference

Glutenin is involved in the gluten-driven mucosal T cell response

31 March 2020

1 reference

Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues

31 March 2020

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Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules

31 March 2020

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Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis

31 March 2020

1 reference

Breast-feeding protects against celiac disease in childhood--epidemiological evidence.

31 March 2020

1 reference

Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins

31 March 2020

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The CTLA4/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI885

1 reference

PubMed ID

12209133

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

12209133