Amyloidogenicity and cytotoxicity of islet amyloid polypeptide (Q34810595)

4 August 2017

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title

Amyloidogenicity and cytotoxicity of islet amyloid polypeptide (English)

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4 August 2017

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Kapurniotu A

1

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4 August 2017

1 January 2001

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4 August 2017

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4 August 2017

60

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4 August 2017

6

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4 August 2017

438-459

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Alternative conformations of amyloidogenic proteins govern their behavior

4 August 2017

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Amyloid fibrillogenesis: themes and variations

21 January 2018

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Deadly conformations--protein misfolding in prion disease

21 January 2018

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In pursuit of the molecular structure of amyloid plaque: new technology provides unexpected and critical information

21 January 2018

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Amyloid diseases: abnormal protein aggregation in neurodegeneration

21 January 2018

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Configurations of Polypeptide Chains With Favored Orientations Around Single Bonds: Two New Pleated Sheets

21 January 2018

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Protein misfolding, evolution and disease

21 January 2018

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Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

21 January 2018

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Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease

21 January 2018

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Amyloid fibril formation requires a chemically discriminating nucleation event: studies of an amyloidogenic sequence from the bacterial protein OsmB

21 January 2018

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For protein misassembly, it's the "I" decade

21 January 2018

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Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology

21 January 2018

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On the Relation of Chronic Interstitial Pancreatitis to the Islands of Langerhans and to Diabetes Melutus

21 January 2018

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Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide

21 January 2018

1 reference

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Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

21 January 2018

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Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

21 January 2018

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Pancreatic islet amyloid formation in patients with noninsulin-dependent diabetes mellitus. Implication for therapeutic strategy

21 January 2018

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Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model

21 January 2018

1 reference

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Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population.

21 January 2018

1 reference

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Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.

21 January 2018

1 reference

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Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide

21 January 2018

1 reference

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Islet amyloid polypeptide in human insulinomas. Evidence for intracellular amyloidogenesis

21 January 2018

1 reference

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Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

21 January 2018

1 reference

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Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.

21 January 2018

1 reference

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21 January 2018

1 reference

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A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas

21 January 2018

1 reference

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Structure and biology of amylin

21 January 2018

1 reference

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Sorting and processing of secretory proteins

21 January 2018

1 reference

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Islet amyloid polypeptide in the islets of Langerhans: friend or foe?

21 January 2018

1 reference

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Mechanism of action of amylin in bone

21 January 2018

1 reference

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Pharmacology of receptors for calcitonin gene-related peptide and amylin

21 January 2018

1 reference

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Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

21 January 2018

1 reference

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Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis

21 January 2018

1 reference

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Amyloid fibrils formed from a segment of the pancreatic islet amyloid protein

21 January 2018

1 reference

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Common core structure of amyloid fibrils by synchrotron X-ray diffraction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Congo red dichroism with dispersed amyloid fibrils, an extrinsic cotton effect

21 January 2018

1 reference

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Vibrational spectroscopy and conformation of peptides, polypeptides, and proteins

21 January 2018

1 reference

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Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease.

21 January 2018

1 reference

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Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein.

21 January 2018

1 reference

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

1 reference

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

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Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide

21 January 2018

1 reference

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Direct measurement of islet amyloid polypeptide fibrillogenesis by mass spectrometry

21 January 2018

1 reference

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A novel assay in vitro of human islet amyloid polypeptide amyloidogenesis and effects of insulin secretory vesicle peptides on amyloid formation

21 January 2018

1 reference

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Islet amyloid polypeptide: identification of long-range contacts and local order on the fibrillogenesis pathway

21 January 2018

1 reference

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Study of the "molten globule" intermediate state in protein folding by a hydrophobic fluorescent probe

21 January 2018

1 reference

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Intermediates in the folding reactions of small proteins

21 January 2018

1 reference

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Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

21 January 2018

1 reference

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Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

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The chemistry of scrapie infection: implications of the 'ice 9' metaphor

21 January 2018

1 reference

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Partially folded intermediates as critical precursors of light chain amyloid fibrils and amorphous aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

21 January 2018

1 reference

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Amyloid fibril formation by an SH3 domain

21 January 2018

1 reference

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Formation of amyloid-like fibrils by self-association of a partially unfolded fibronectin type III module

21 January 2018

1 reference

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Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

21 January 2018

1 reference

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On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants

21 January 2018

1 reference

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Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Islet amyloid polypeptide (IAPP):cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Empirical Predictions of Protein Conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

The anatomy and taxonomy of protein structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Effects of sequential proline substitutions on amyloid formation by human amylin20-29.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Analysis of the minimal amyloid-forming fragment of the islet amyloid polypeptide. An experimental support for the key role of the phenylalanine residue in amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Structural model for the beta-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

A possible role for pi-stacking in the self-assembly of amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Missense mutation of amylin gene (S20G) in Japanese NIDDM patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type amylin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Enhanced in vitro production of amyloid-like fibrils from mutant (S20G) islet amyloid polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Analysis of amylin cleavage products provides new insights into the amyloidogenic region of human amylin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Amyloidogenicity of recombinant human pro-islet amyloid polypeptide (ProIAPP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Molecular model-building of amylin and alpha-calcitonin gene-related polypeptide hormones using a combination of knowledge sources.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Different sensitivity to the cytotoxic action of IAPP fibrils in two insulin-producing cell lines, HIT-T15 and RINm5F cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Fibrillar islet amyloid polypeptide differentially affects oxidative mechanisms and lipoprotein uptake in correlation with cytotoxicity in two insulin-producing cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Rifampicin inhibits the toxicity of pre-aggregated amyloid peptides by binding to peptide fibrils and preventing amyloid-cell interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Amyloid peptides are toxic via a common oxidative mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Induction of apoptosis by human amylin in RINm5F islet beta-cells is associated with enhanced expression of p53 and p21WAF1/CIP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: a general strategy to prevent amyloid formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

The cell cycle effects of camptothecin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Amyloid and polypeptide hormones: What is their interrelationship?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

Sequence of raccoon IAPP supports importance of a specific structural motif in the development of pancreatic islet amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0282%282001%2960%3A6%3C438%3A%3AAID-BIP10182%3E3.0.CO%3B2-A

10.1002/1097-0282(2001)60:6<438::AID-BIP10182>3.0.CO;2-A

21 January 2018

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12209476