Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a (Q34818314)

4 August 2017

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title

Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a (English)

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4 August 2017

Albert J Fornace

2

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author name string

M Christine Hollander

series ordinal

1

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PubMed ID

12214253

4 August 2017

language of work or name

English

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publication date

1 September 2002

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4 August 2017

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4 August 2017

21

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4 August 2017

40

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4 August 2017

6228-6233

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205774

4 August 2017

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cites work

Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

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Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p

21 January 2018

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The pathology of familial breast cancer: How do the functions of BRCA1 and BRCA2 relate to breast tumour pathology?

21 January 2018

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Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

21 January 2018

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Translocations involving c-myc and c-myc function

21 January 2018

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c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets

21 January 2018

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Genomic instability in mice lacking histone H2AX

21 January 2018

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The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast

21 January 2018

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Mec1p regulates Pds1p levels in S phase: complex coordination of DNA replication and mitosis

21 January 2018

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The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway

21 January 2018

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Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

21 January 2018

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

21 January 2018

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Tumor formation in Brca1 conditional mutant mice

21 January 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

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Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

21 January 2018

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DNA double strand break repair and chromosomal translocation: lessons from animal models

21 January 2018

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Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents

21 January 2018

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Abnormal centrosome amplification in the absence of p53.

21 January 2018

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Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells.

21 January 2018

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Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

21 January 2018

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p53 mutations in human cancers

21 January 2018

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BRCA1 is associated with the centrosome during mitosis.

21 January 2018

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BRCA1 activation of the GADD45 promoter.

21 January 2018

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

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DNA double-strand breaks: signaling, repair and the cancer connection

21 January 2018

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Transforming ability of Gag-Myc fusion proteins correlates with Gag-Myc protein stability and transcriptional repression

21 January 2018

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Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development

21 January 2018

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PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

c-Myc overexpression uncouples DNA replication from mitosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Distinct functions of BRCA1 and BRCA2 in double-strand break repair

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Decreased accumulation and dephosphorylation of the mitosis-specific form of nucleophosmin/B23 in staurosporine-induced chromosome decondensation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Repression of BRCA1 through a feedback loop involving p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Wild-type murine p53 represses transcription from the murine c-myc promoter in a human glial cell line

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Origin and mechanisms of non-disjunction in human autosomal trisomies

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

The myc oncogene: MarvelouslY Complex

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

BRCA1 signals ARF-dependent stabilization and coactivation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Deregulated cyclin E induces chromosome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

High frequency of spontaneous translocations revealed by FISH in cells from patients with the cancer-prone syndromes ataxia telangiectasia and Nijmegen breakage syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Normal diploid human and rodent cells lack a detectable frequency of gene amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

GADD45 induction of a G2/M cell cycle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Abrogation of p53 function affects gadd gene responses to DNA base-damaging agents and starvation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Myc represses the growth arrest gene gadd45

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

7 January 2021

Natriuretic peptide immunoreactivity in nerve structures and Purkinje fibres of human, pig and sheep hearts.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

7 January 2021

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

7 January 2021

Genomic instability in Gadd45a-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

7 January 2021

Defining the galaxy of gene expression in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

7 January 2021

Nurse faculty job satisfaction: a national survey.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

7 January 2021

Origin and evolution of binucleated cells and binucleated cells with micronuclei in cisplatin-treated CHO cultures

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205774

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205774

1 reference

PubMed ID

12214253

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

12214253