Genomic and nongenomic effects of glucocorticoids (Q34819002)

4 August 2017

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title

Genomic and nongenomic effects of glucocorticoids (English)

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4 August 2017

2

Frank Buttgereit

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author name string

Cindy Stahn

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1

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4 August 2017

2 September 2008

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Nature Clinical Practice Rheumatology

4 August 2017

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4 August 2017

4

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4 August 2017

10

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4 August 2017

525-533

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Optimised glucocorticoid therapy: the sharpening of an old spear

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The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors

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Direct interaction of the tau 1 transactivation domain of the human glucocorticoid receptor with the basal transcriptional machinery

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Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands

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Current use of glucocorticoids in patients with rheumatoid arthritis in Germany

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Glucocorticoids in the treatment of rheumatic diseases: an update on the mechanisms of action

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Are Glucocorticoids DMARDs?

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Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists

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The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis

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Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

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Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data.

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Oral corticosteroids and fracture risk: relationship to daily and cumulative doses

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Revisiting the toxicity of low-dose glucocorticoids: risks and fears

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Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology

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EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases.

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Mechanisms involved in the side effects of glucocorticoids

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Corticosteroid-insensitive asthma: molecular mechanisms.

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Glucocorticoid action and novel mechanisms of steroid resistance: role of glucocorticoid receptor-interacting proteins for glucocorticoid responsiveness

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Rapid glucocorticoid effects on immune cells

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Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands

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7 January 2021

Primary structure and expression of a functional human glucocorticoid receptor cDNA

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The origin and functions of multiple human glucocorticoid receptor isoforms

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Mechanisms of Corticosteroid Resistance in Rheumatoid Arthritis

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The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action

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Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein

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Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor

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7 January 2021

Steroid hormone receptors: an update

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7 January 2021

Chaperoning of glucocorticoid receptors

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7 January 2021

Zap70 signaling pathway mediates glucocorticoid receptor-dependent transcriptional activation: role in the regulation of annexin 1 expression in T cells

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7 January 2021

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene

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7 January 2021

Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell

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7 January 2021

The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

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7 January 2021

Insight into the molecular mechanisms of glucocorticoid receptor action promotes identification of novel ligands with an improved therapeutic index.

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7 January 2021

The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings.

1 reference

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Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism

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Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase

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Bioenergetics of immune functions: fundamental and therapeutic aspects

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The plasma membrane estrogen receptor: nuclear or unclear?

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Plasma membrane-resident glucocorticoid receptors in rodent lymphoma and human leukemia models

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A corticosteroid receptor in neuronal membranes.

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7 January 2021

Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis.

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7 January 2021

Non-genomic glucocorticoid effects to provide the basis for new drug developments

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Membrane glucocorticoid receptors are down regulated by glucocorticoids in patients with systemic lupus erythematosus and use a caveolin-1-independent expression pathway

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Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn.

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Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN

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Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis

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Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes

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Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids

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Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis

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Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial

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Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index.

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trans-Activation and repression properties of the novel nonsteroid glucocorticoid receptor ligand 2,5-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(1-methylcyclohexen-3-y1)-1H-[1]benzopyrano[3,4-f]quinoline (A276575) and its four stereoisomers

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Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile

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7 January 2021

LGD-5552, an antiinflammatory glucocorticoid receptor ligand with reduced side effects, in vivo

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Identifiers

DOI

10.1038/NCPRHEUM0898

1 reference

release_iw3cpsspbrhyjnpgzlgcv32vtm

4 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/iw3cpsspbrhyjnpgzlgcv32vtm

24 November 2022

mapped directly with Wikidata item

PubMed ID

18762788

1 reference

PubMed ID

18762788