Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy (Q34856807)

4 August 2017

Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy (English)

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obesity due to congenital leptin deficiency

4 August 2017

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4

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4 August 2017

Gilberto Paz-Filho

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Claudio A. Mastronardi

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Claudio Mastronardi

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2

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Julio Licinio

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Julio Licinio

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5

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author name string

Tuncay Delibasi

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3

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4 August 2017

1 November 2010

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Arquivos Brasileiros de Endocrinologia e Metabologia

4 August 2017

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4 August 2017

54

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4 August 2017

8

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4 August 2017

690-697

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A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Narrative review: the role of leptin in human physiology: emerging clinical applications

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Congenital leptin deficiency and thyroid function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Leptin replacement improves cognitive development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Leptin replacement alters brain response to food cues in genetically leptin-deficient adults

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Leptin regulates striatal regions and human eating behavior

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Effect of leptin replacement on brain structure in genetically leptin-deficient adults

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin,

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Leptin, leptin receptors, and the control of body weight.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Congenital leptin deficiency is associated with severe early-onset obesity in humans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Human leptin levels are pulsatile and inversely related to pituitary-adrenal function.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Positional cloning of the mouse obese gene and its human homologue

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Adipokine expression profile in adipocytes of different mouse models of obesity.

8 July 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000800005

A leptin missense mutation associated with hypogonadism and morbid obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000800005

A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000800005

Deconvolution of insulin secretion, insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals: time course of glucose homeostasis in leptin replacement treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000800005

Effects of leptin replacement on risk factors for cardiovascular disease in genetically leptin-deficient subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000800005

Leptin levels and Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000800005

Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000800005

Cellular immunity before and after leptin replacement therapy

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Regulation of thyrotropin synthesis and secretion

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4286252

Effects of leptin replacement on macro- and micronutrient preferences

26 October 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000800005

[The hypothalamic control of feeding and thermogenesis: implications on the development of obesity]

21 January 2018

1 reference

12 December 2020

Decrease in leptin production by the adipose tissue in obesity associated with severe metabolic syndrome

1 reference

12 December 2020

[Metabolic profile according to leptin levels in obese patients]

1 reference

12 December 2020

Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals

1 reference

12 December 2020

10.1590/S0004-27302010000800005

Identifiers

DOI

1 reference

4 August 2017

1 reference

4 August 2017

1 reference

PubMed ID

21340154