Role of protease-activated receptors in airway function: a target for therapeutic intervention? (Q34874973)

5 August 2017

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title

Role of protease-activated receptors in airway function: a target for therapeutic intervention? (English)

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5 August 2017

Peter J Henry

3

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author name string

Rommel S Lan

series ordinal

1

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PubMed ID

12243797

5 August 2017

Geoffrey A Stewart

series ordinal

2

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5 August 2017

1 September 2002

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Pharmacology & Therapeutics

5 August 2017

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5 August 2017

95

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5 August 2017

3

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5 August 2017

239-257

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Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation

1 reference

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7 January 2021

An assay for high-sensitivity detection of thrombin activity and determination of proteases activating or inactivating protease-activated receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protective effect of a thrombin receptor (protease-activated receptor 1) gene polymorphism toward venous thromboembolism

1 reference

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

1 reference

7 January 2021

Chronic obstructive pulmonary disease: new opportunities for drug development

1 reference

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7 January 2021

Chronic obstructive pulmonary disease

1 reference

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7 January 2021

Expression of cyclo-oxygenase-2 in human airway smooth muscle is associated with profound reductions in cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Development of potent thrombin receptor antagonist peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Mast-cell responses in the development of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Ligand cross-reactivity within the protease-activated receptor family.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Mechanisms of desensitization and resensitization of proteinase-activated receptor-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Factor Xa activates endothelial cells by a receptor cascade between EPR-1 and PAR-2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Asthma. From bronchoconstriction to airways inflammation and remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Evidence for functionally active protease-activated receptor-4 (PAR-4) in human vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Bronchoprotector properties of calcitonin gene-related peptide in guinea pig and human airways. Effect of pulmonary inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Trypsin-induced, neurokinin-mediated contraction of guinea pig bronchus

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Role of enzymes mediating thrombosis and thrombolysis in lung disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Effect of protease-activated receptor (PAR)-1, -2 and -4-activating peptides, thrombin and trypsin in rat isolated airways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Bronchoconstrictor effect of thrombin and thrombin receptor activating peptide in guinea-pigs in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease-activated receptor-2 involvement in hypotension in normal and endotoxemic rats in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protective effect of a PAR2-activating peptide on histamine-induced bronchoconstriction in guinea-pig

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin functions as an inflammatory mediator through activation of its receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease-activated receptor-2 (PAR2) in the airways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

A protective role for protease-activated receptors in the airways

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https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin receptor activating peptides: importance of the N-terminal serine and its ionization state as judged by pH dependence, nuclear magnetic resonance spectroscopy, and cleavage by aminopeptidase M

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

How the protease thrombin talks to cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease-activated receptor-2-mediated inhibition of ion transport in human bronchial epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Localization of protease-activated receptors-1 and -2 in human mast cells: indications for an amplified mast cell degranulation cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Role of endogenous nitric oxide in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Physiologic Basis and Interpretation of Common Indices of Respiratory Mechanical Function

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Mouse models of airway responsiveness: physiological basis of observed outcomes and analysis of selected examples using these outcome indicators

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Identification of potential activators of proteinase-activated receptor-2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin in the airways of asthmatic patients

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The protease-antiprotease balance within the human lung: implications for the pathogenesis of emphysema

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The role of particulate matter in exacerbation of atopic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin induces IL-6 but not TNFalpha secretion by mouse mast cells: threshold-level thrombin receptor and very low level FcepsilonRI signaling synergistically enhance IL-6 secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Mechanism for Activation of Mouse Mast Cell Tryptase: Dependence on Heparin and Acidic pH for Formation of Active Tetramers of Mouse Mast Cell Protease 6†

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Atypical protease-activated receptor mediates endothelium-dependent relaxation of human coronary arteries.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Regulation of the inflammatory response in asthma by mast cell products

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Injury to murine airway epithelial cells by pollen enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Receptor binding and agonist efficacy: new insights from mutants of the thrombin protease-activated receptor-1 (PAR-1)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Synergistic actions of a thrombin-derived synthetic peptide and a thrombin receptor-activating peptide in stimulating fibroblast mitogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Peripheral blood lymphocytes express the platelet-type thrombin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Formation of enzymatically active, homotypic, and heterotypic tetramers of mouse mast cell tryptases. Dependence on a conserved Trp-rich domain on the surface.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Anticoagulants for acute respiratory distress syndrome: can they work?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease-activated receptor 3 is a second thrombin receptor in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Expression of protease-activated receptor-2 during embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The N-terminal thrombin receptor fragment SFLLRN, but not catalytically inactive thrombin-derived agonists, activate U937 human monocytic cells: evidence for receptor hydrolysis in thrombin-dependent signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Gene and locus structure and chromosomal localization of the protease-activated receptor gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

A dual thrombin receptor system for platelet activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hindpaw

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Enhancement of vascular permeability by specific activation of protease-activated receptor-1 in rat hindpaw: a protective role of endogenous and exogenous nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Factor Xa-evoked relaxation in rat aorta: involvement of PAR-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Ex vivo evidence that the phosphodiesterase inhibitor IBMX attenuates the up-regulation of PAR-2 in the endotoxemic rat aorta

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms: an immunohistochemical study

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Cellular proteases involved in the pathogenicity of enveloped animal viruses, human immunodeficiency virus, influenza virus A and Sendai virus

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The proteinase-antiproteinase theory of emphysema: a speculative analysis of recent advances into the pathogenesis of emphysema

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Expression of trypsin in vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Persistent wheezing in very young children is associated with lower respiratory inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Plasmin Desensitization of the PAR1 Thrombin Receptor: Kinetics, Sites of Truncation, and Implications for Thrombolytic Therapy†

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Modulation of airway smooth muscle tone by protease activated receptor-1,-2,-3 and -4 in trachea isolated from influenza A virus-infected mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Role of PGE(2) in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Vascular actions of thrombin receptor-derived polypeptides: structure-activity profiles for contractile and relaxant effects in rat aorta

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The concept of airway inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Understanding the pathogenesis of allergic asthma using mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Delayed onset of inflammation in protease-activated receptor-2-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The relationship between airways inflammation and asthma severity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin upregulates interleukin-8 in lung fibroblasts via cleavage of proteolytically activated receptor-I and protein kinase C-gamma activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin and trypsin-induced Ca(2+) mobilization in human T cell lines through interaction with different protease-activated receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease-activated receptor-2 (PAR-2): structure-function study of receptor activation by diverse peptides related to tethered-ligand epitopes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Balance in asthma between matrix metalloproteinases and their inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Human mast cell subsets--distinct functions in inflammation?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Interactions of mast cell tryptase with thrombin receptors and PAR-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Endothelial cell thrombin receptors and PAR-2. Two protease-activated receptors located in a single cellular environment

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Mini-plasmin found in the epithelial cells of bronchioles triggers infection by broad-spectrum influenza A viruses and Sendai virus

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The dual role of thrombin's anion-binding exosite-I in the recognition and cleavage of the protease-activated receptor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

PAR3 is a cofactor for PAR4 activation by thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Expression of leukocyte integrins and tissue factor in mononuclear phagocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin receptor expression and responsiveness of human monocytic cells to thrombin is linked to interferon-induced cellular differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin receptor expression in normal and atherosclerotic human arteries

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease activated receptors: theme and variations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Microvascular leakage in the airway wall and lumen during allergen induced early and late responses in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Inhibition of arterial thrombosis by a peptide ligand of the thrombin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

alpha-Thrombin increases cytosolic calcium and induces human airway smooth muscle cell proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

COX-2 expression in asthmatic airways: the story so far.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Identification of new single-nucleotide polymorphisms in the thrombin receptor gene and their effects on coronary artery diseases in Koreans

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Cleavage of the thrombin receptor: identification of potential activators and inactivators

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Bronchoprotective role for endogenous prostaglandin E2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Effect of Inhaled Prostaglandin E2on Allergen-induced Asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Recombinant human Monocyte/Neutrophil elastase inhibitor protects rat lungs against injury from cystic fibrosis airway secretions

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease injury in airways disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Presence and bronchomotor activity of protease-activated receptor-2 in guinea pig airways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor heterogeneity.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Indications for the presence of an atypical protease-activated receptor on rat platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Contractile actions of proteinase-activated receptor-derived polypeptides in guinea-pig gastric and lung parenchymal strips: evidence for distinct receptor systems

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Cathepsin G activates protease-activated receptor-4 in human platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Expression and function of proteinase-activated receptor 2 in human bronchial smooth muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The human thrombin receptor and proteinase activated receptor-2 genes are tightly linked on chromosome 5q13

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Procoagulant and fibrinolytic properties of bovine endothelial cells treated with monocrotaline pyrrole

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Inhibition of thrombin and SFLLR-peptide stimulation of platelet aggregation, phospholipase A2 and Na+/H+ exchange by a thrombin receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Presence, activities, and molecular forms of cathepsin G, elastase, alpha 1-antitrypsin, and alpha 1-antichymotrypsin in bronchiectasis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Matrix metalloproteinases. Matrix degradation and more

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The human mast cell tryptase tetramer: a fascinating riddle solved by structure

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Natural history of aspirin-induced asthma. AIANE Investigators. European Network on Aspirin-Induced Asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Granzyme activity in the inflamed lung is not controlled by endogenous serine proteinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Activation of rat mast cells upon stimulation of protease-activated receptor (PAR-1)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Peptidases: structure, function and modulation of peptide-mediated effects in the human lung

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Pro- and anti-inflammatory actions of thrombin: a distinct role for proteinase-activated receptor-1 (PAR1).

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Airway epithelial cells release eosinophil survival-promoting factors (GM-CSF) after stimulation of proteinase-activated receptor 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Matrix metalloproteinases: effectors of development and normal physiology

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Domains specifying thrombin–receptor interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Cloning and characterization of human protease-activated receptor 4

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Purification, characterization, and localization of a novel trypsin-like protease found in the human airway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Excessive neutrophil elastase in bronchoalveolar lavage fluid in subclinical emphysema

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

Mast cell tryptase and asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900237-1

7 January 2021

10.1016/S0163-7258(02)00237-1

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12243797