Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin (Q34887145)

5 August 2017

Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin (English)

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5 August 2017

F A Scholl

1

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5 August 2017

P A Dumesic

2

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5 August 2017

D I Barragan

3

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5 August 2017

J Charron

4

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5 August 2017

P A Khavari

5

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5 August 2017

language of work or name

English

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publication date

9 February 2009

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5 August 2017

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5 August 2017

28

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5 August 2017

12

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5 August 2017

1485-1495

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https://scigraph.springernature.com/pub.10.1038/onc.2008.459

5 August 2017

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8 July 2018

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More than one way to skin . .

8 July 2018

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MAP kinase: it's been longer than fifteen minutes

8 July 2018

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Cre activity causes widespread apoptosis and lethal anemia during embryonic development.

8 July 2018

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Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy

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Vagaries of conditional gene targeting

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Histological and proteomic analysis of reversible H-RasV12G expression in transgenic mouse skin.

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Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

8 July 2018

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MAP kinase signalling pathways in cancer

8 July 2018

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Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors.

8 July 2018

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An unexpected new role of mutant Ras: perturbation of human embryonic development

8 July 2018

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ERK implication in cell cycle regulation

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The MEK/ERK cascade: from signaling specificity to diverse functions

8 July 2018

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Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis.

8 July 2018

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The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

8 July 2018

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Progress towards therapeutic small molecule MEK inhibitors for use in cancer therapy

8 July 2018

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RalGDS is required for tumor formation in a model of skin carcinogenesis.

8 July 2018

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Mek2 is dispensable for mouse growth and development

8 July 2018

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Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation

8 July 2018

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The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin

8 July 2018

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Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

8 July 2018

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Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

8 July 2018

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Ras-dependent activation of the small GTPase Ral.

8 July 2018

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Ras gene mutation and amplification in human nonmelanoma skin cancers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084589

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

8 July 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.459

Phosphorelay signalling: new tricks for an ancient pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.459

Measuring Ras-family GTP levels in vivo--running hot and cold

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.459

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.459

Oncogenic signaling of class I PI3K isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.459

Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.459

Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.459

Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.459

Mek1 alters epidermal growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.459

Biochemical and biological characterization of tumor-associated mutations of p110alpha.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084589

Inducible activation of Ras and Raf in adult epidermis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084589

The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted

26 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.459

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.459

The level of oncogene H-Ras correlates with tumorigenicity and malignancy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.459

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.459

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Dimensions Publication ID

5 August 2017

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5 August 2017

1 reference