Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. (Q34894220)

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English	Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.	scientific article

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23 January 2020

Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome (English)

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23 January 2020

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metabolic syndrome

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based on heuristic

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23 January 2020

Michael J. Quon

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23 January 2020

Michael J. Quon

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23 January 2020

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Stefano Rizza

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23 January 2020

Ranganath Muniyappa

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23 January 2020

Micaela Iantorno

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23 January 2020

Jeong-a Kim

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23 January 2020

Hui Chen

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23 January 2020

Philomena Pullikotil

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23 January 2020

Nicoletta Senese

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23 January 2020

Manfredi Tesauro

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23 January 2020

Carmine Cardillo

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23 January 2020

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23 February 2011

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23 January 2020

The Journal of Clinical Endocrinology and Metabolism

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23 January 2020

96

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23 January 2020

5

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23 January 2020

E782-92

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23 January 2020

The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention

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Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression

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C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcgammaRIIB and SHIP-1.

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Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes

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Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension

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8 July 2018

Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials

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8 July 2018

Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells

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8 July 2018

Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease

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8 July 2018

Cardiovascular actions of insulin

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8 July 2018

Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin

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8 July 2018

Nitric oxide and atherosclerosis: an update

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Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.

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8 July 2018

Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial.

1 reference

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8 July 2018

Inhibition of microsomal triglyceride transfer protein expression and apolipoprotein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes

1 reference

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8 July 2018

Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies

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8 July 2018

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

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8 July 2018

Role of endothelial dysfunction in atherosclerosis

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8 July 2018

Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition

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8 July 2018

Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

8 July 2018

Insulin resistance and chronic cardiovascular inflammatory syndrome

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8 July 2018

Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).

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8 July 2018

Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells

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8 July 2018

Cellular adhesion molecules and atherogenesis

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8 July 2018

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

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8 July 2018

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

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8 July 2018

Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study

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8 July 2018

Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study

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8 July 2018

Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

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8 July 2018

The EGCg-induced redox-sensitive activation of endothelial nitric oxide synthase and relaxation are critically dependent on hydroxyl moieties

1 reference

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26 October 2018

Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

Orange juice or fructose intake does not induce oxidative and inflammatory response.

1 reference

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26 October 2018

Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn.

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26 October 2018

Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women.

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26 October 2018

Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR.

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26 October 2018

Treatment of spontaneously hypertensive rats with rosiglitazone and/or enalapril restores balance between vasodilator and vasoconstrictor actions of insulin with simultaneous improvement in hypertension and insulin resistance.

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26 October 2018

Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium.

1 reference

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26 October 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (+/-)-naringenin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

Effects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: preferential reduction in elevated serum triglyceride level.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

Effects of long-term administration of hesperidin and glucosyl hesperidin to spontaneously hypertensive rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3085197

26 October 2018

Flavonoid content of U.S. fruits, vegetables, and nuts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21346065

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women

1 reference

https://pubmed.ncbi.nlm.nih.gov/21346065

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/21346065

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMP-activated protein kinase phosphorylation of endothelial NO synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21346065

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21346065

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1210/JC.2010-2879

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Europe PubMed Central

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23 January 2020

1 reference

Europe PubMed Central

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23 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346065%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

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