Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. (Q34915672)

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7 March 2020

title

Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion (English)

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7 March 2020

1

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Paul W Bowyer

7

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10

John C Boothroyd

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7 March 2020

author name string

Carolyn I Hall

2

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7 March 2020

Josh R Beck

3

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7 March 2020

Leslie O Ofori

4

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Victoria E Albrow

5

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7 March 2020

Megan Garland

6

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7 March 2020

Peter J Bradley

8

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7 March 2020

James C Powers

9

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Eranthie Weerapana

11

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7 March 2020

Matthew Bogyo

12

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7 March 2020

publication date

11 August 2013

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7 March 2020

published in

Nature Chemical Biology

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7 March 2020

volume

9

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issue

10

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7 March 2020

page(s)

651-656

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An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes

7 March 2020

cites work

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The Toxoplasma protein ARO mediates the apical positioning of rhoptry organelles, a prerequisite for host cell invasion.

8 July 2018

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A Toxoplasma palmitoyl acyl transferase and the palmitoylated armadillo repeat protein TgARO govern apical rhoptry tethering and reveal a critical role for the rhoptries in host cell invasion but not egress

8 July 2018

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8 July 2018

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A forward genetic screen reveals that calcium-dependent protein kinase 3 regulates egress in Toxoplasma

8 July 2018

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Distinct signalling pathways control Toxoplasma egress and host-cell invasion

8 July 2018

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Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis

8 July 2018

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Protein palmitoylation inhibition by 2-bromopalmitate alters gliding, host cell invasion and parasite morphology in Toxoplasma gondii

8 July 2018

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Global profiling of dynamic protein palmitoylation

8 July 2018

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Activity-Based Protein Profiling (ABPP) and Click Chemistry (CC)-ABPP by MudPIT Mass Spectrometry

8 July 2018

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Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion

8 July 2018

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Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases.

8 July 2018

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Functional dissection of the apicomplexan glideosome molecular architecture

8 July 2018

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Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

8 July 2018

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Small-molecule inhibition of APT1 affects Ras localization and signaling

8 July 2018

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A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin during Toxoplasma gondii infection

8 July 2018

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Calcium-dependent signaling and kinases in apicomplexan parasites

8 July 2018

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Palmitoylation of the synaptic vesicle fusion machinery.

8 July 2018

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Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80

8 July 2018

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Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining

8 July 2018

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Isocoumarin-based inhibitors of pancreatic cholesterol esterase

8 July 2018

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Toxoplasma MIC2 is a major determinant of invasion and virulence

8 July 2018

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The glideosome: a molecular machine powering motility and host-cell invasion by Apicomplexa.

8 July 2018

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A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii

8 July 2018

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8 July 2018

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Role of calcium during Toxoplasma gondii invasion and egress

8 July 2018

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Characterization of Saccharomyces cerevisiae acyl-protein thioesterase 1, the enzyme responsible for G protein alpha subunit deacylation in vivo

8 July 2018

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Microneme proteins: structural and functional requirements to promote adhesion and invasion by the apicomplexan parasite Toxoplasma gondii.

8 July 2018

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Ionophore-resistant mutants of Toxoplasma gondii reveal host cell permeabilization as an early event in egress

8 July 2018

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8 July 2018

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8 July 2018

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A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS)

8 July 2018

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8 July 2018

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Mechanism-based isocoumarin inhibitors for serine proteases: use of active site structure and substrate specificity in inhibitor design

8 July 2018

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Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes

8 July 2018

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Rapid control of protein level in the apicomplexan Toxoplasma gondii

21 January 2018

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Dual acylation of the 45 kDa gliding-associated protein (GAP45) in Plasmodium falciparum merozoites.

21 January 2018

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Induction and regulation of conoid extrusion in Toxoplasma gondii.

21 January 2018

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Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes.

21 January 2018

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Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for hit-and-run mutagenesis

21 January 2018

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Mobilization of intracellular calcium stimulates microneme discharge in Toxoplasma gondii

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23934245

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Secretion of micronemal proteins is associated with toxoplasma invasion of host cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23934245

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Protein Acylation: New Potential Targets for Intervention against the Apicomplexa

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1315

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1315

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23934245%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23934245%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

23934245

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23934245%20AND%20SRC:MED&resulttype=core&format=json