Dimerization, ubiquitylation and endocytosis go together in growth hormone receptor function (Q34922254)

5 August 2017

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title

Dimerization, ubiquitylation and endocytosis go together in growth hormone receptor function (English)

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5 August 2017

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Ger J Strous

1

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PubMed ID

12354620

5 August 2017

Jürgen Gent

series ordinal

2

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PubMed ID

12354620

5 August 2017

language of work or name

English

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publication date

1 October 2002

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5 August 2017

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5 August 2017

529

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5 August 2017

1

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5 August 2017

102-109

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

5 August 2017

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A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

A ubiquitin mutant with specific defects in DNA repair and multiubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase.

21 January 2018

1 reference

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A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Membrane-bound transcription factors: regulated release by RIP or RUP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Ubiquitin is required for sorting to the vacuole of the yeast general amino acid permease, Gap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding

21 January 2018

1 reference

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21 January 2018

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Functional involvement of a novel Nedd4-like ubiquitin ligase on retrovirus budding

21 January 2018

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21 January 2018

RING for destruction?

1 reference

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Cbl: many adaptations to regulate protein tyrosine kinases

21 January 2018

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

21 January 2018

1 reference

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The anaphase-promoting complex: new subunits and regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

SCF and Cullin/Ring H2-based ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

21 January 2018

1 reference

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The U box is a modified RING finger — a common domain in ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

U box proteins as a new family of ubiquitin-protein ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

The 26S proteasome: a molecular machine designed for controlled proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Antigen processing by the proteasome

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Proteasome inhibitors: valuable new tools for cell biologists

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Endoplasmic reticulum degradation. Reverse protein transport and its end in the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Proteasomes regulate the duration of erythropoietin receptor activation by controlling down-regulation of cell surface receptors

21 January 2018

1 reference

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Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Protein regulation by monoubiquitin

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Monoubiquitin carries a novel internalization signal that is appended to activated receptors

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Epidermal growth factor induces ubiquitination of Eps15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Growth hormone signalling and its regulation: preventing too much of a good thing

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Growth hormone receptor ubiquitination coincides with recruitment to clathrin-coated membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Cytoplasmic tail phosphorylation of the alpha-factor receptor is required for its ubiquitination and internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Growth hormone receptor ubiquitination, endocytosis, and degradation are independent of signal transduction via Janus kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Molecular mechanism of growth hormone action

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain

21 January 2018

1 reference

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Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer

21 January 2018

1 reference

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A dimerization motif for transmembrane α–helices

21 January 2018

1 reference

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A transmembrane helix dimer: structure and implications

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903187-3

Structure of the transmembrane dimer interface of glycophorin A in membrane bilayers

21 January 2018

1 reference

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Specificity in transmembrane helix-helix interactions can define a hierarchy of stability for sequence variants

21 January 2018

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The GxxxG motif: a framework for transmembrane helix-helix association

21 January 2018

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Dimerisation of the glycophorin A transmembrane segment in membranes probed with the ToxR transcription activator.

21 January 2018

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Dimerization of the polymeric immunoglobulin receptor controls its transcytotic trafficking

21 January 2018

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A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein

21 January 2018

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Molecular recognition within the membrane milieu: implications for the structure and function of membrane Pproteins

21 January 2018

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Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor

21 January 2018

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Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

21 January 2018

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Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130.

21 January 2018

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The single transmembrane domains of ErbB receptors self-associate in cell membranes

21 January 2018

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Role of transmembrane domain interactions in the assembly of class II MHC molecules

21 January 2018

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Oligomeric structure of type I and type II transforming growth factor beta receptors: homodimers form in the ER and persist at the plasma membrane

21 January 2018

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Transmembrane helical interactions and the assembly of the T cell receptor complex

21 January 2018

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A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling

21 January 2018

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Regulation of ubiquitin-dependent processes by deubiquitinating enzymes

21 January 2018

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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

7 January 2021

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Tsg101: HIV-1's ticket to ride

7 January 2021

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Endocytosis and degradation of the growth hormone receptor are proteasome-dependent

7 January 2021

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Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain

7 January 2021

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Glycophorins: isolation, orientation, and localization of specific domains

7 January 2021

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10.1016/S0014-5793(02)03187-3

7 January 2021

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12354620