Regulation of mast-cell and basophil function and survival by IgE. (Q34931931)

5 August 2017

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title

Regulation of mast-cell and basophil function and survival by IgE. (English)

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mast cell apoptotic process

5 August 2017

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Gene Ontology release 2020-05-02

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Gene Ontology release 2020-05-02

2

Stephen J Galli

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5 August 2017

Toshiaki Kawakami

1

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5 August 2017

1 October 2002

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Nature Reviews Immunology

5 August 2017

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5 August 2017

2

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5 August 2017

10

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5 August 2017

773-786

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Heterogeneity of mast cells and phenotypic change between subpopulations

5 August 2017

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31 March 2020

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31 March 2020

Mast cells and basophils

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The diverse potential effector and immunoregulatory roles of mast cells in allergic disease

31 March 2020

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Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11

31 March 2020

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The receptor with high affinity for IgE.

31 March 2020

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Signalling through the high-affinity IgE receptor Fc epsilonRI.

31 March 2020

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Roles of mast cells and basophils in innate and acquired immunity

31 March 2020

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Complexity and redundancy in the pathogenesis of asthma: reassessing the roles of mast cells and T cells

31 March 2020

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Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice

31 March 2020

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An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model

31 March 2020

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Induction of human IgE synthesis in B cells by mast cells and basophils

31 March 2020

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Unravelling the mast cell dilemma: culprit or victim of its generosity?

31 March 2020

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Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

31 March 2020

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31 March 2020

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Crystal structure of the human high-affinity IgE receptor

31 March 2020

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Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha

31 March 2020

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Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells

31 March 2020

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Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

31 March 2020

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Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking

31 March 2020

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syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction

31 March 2020

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Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides

31 March 2020

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Structural aspects of the association of FcepsilonRI with detergent-resistant membranes

31 March 2020

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Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes

31 March 2020

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Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains

31 March 2020

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Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling

31 March 2020

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Fc(epsilon)RI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells

31 March 2020

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High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT.

31 March 2020

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Observing FcepsilonRI signaling from the inside of the mast cell membrane

31 March 2020

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31 March 2020

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Activating and inhibitory signaling in mast cells: new opportunities for therapeutic intervention?

31 March 2020

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Immune inhibitory receptors

31 March 2020

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Building up the family of ITIM-bearing negative coreceptors

31 March 2020

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Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif

31 March 2020

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The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells

31 March 2020

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The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation

31 March 2020

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Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE.

31 March 2020

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gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization

31 March 2020

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gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation

31 March 2020

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Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice

31 March 2020

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Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal

31 March 2020

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The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1.

31 March 2020

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Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1

31 March 2020

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Inhibition of IgE-mediated mast cell activation by the paired Ig-like receptor PIR-B

31 March 2020

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A secretion inhibitory signal transduction molecule on mast cells is another C-type lectin.

31 March 2020

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Possible interactions between the Fcε receptor and a novel mast cell function-associated antigen

31 March 2020

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The mast cell function-associated antigen and its interactions with the type I Fcepsilon receptor

31 March 2020

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Proximity relationships between the type I receptor for Fc epsilon (Fc epsilon RI) and the mast cell function-associated antigen (MAFA) studied by donor photobleaching fluorescence resonance energy transfer microscopy.

31 March 2020

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SH2 domain-containing inositol polyphosphate 5'-phosphatase is the main mediator of the inhibitory action of the mast cell function-associated antigen

31 March 2020

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The protein tyrosine kinase syk activity is reduced by clustering the mast cell function-associated antigen

31 March 2020

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IgE receptors on human basophils. Relationship to serum IgE concentration

31 March 2020

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The receptor for immunoglobulin E on rat basophilic leukemia cells: effect of ligand binding on receptor expression

31 March 2020

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Coordinate synthesis and degradation of the alpha-, beta- and gamma-subunits of the receptor for immunoglobulin E.

31 March 2020

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IgE antibody up-regulates high affinity IgE binding on murine bone marrow-derived mast cells.

31 March 2020

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IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions

31 March 2020

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Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking: enhanced IL-13 production by IL-4-primed human mast cells

31 March 2020

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Minimal requirements for IgE-mediated regulation of surface Fc epsilon RI.

31 March 2020

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Drastic up-regulation of Fcepsilonri on mast cells is induced by IgE binding through stabilization and accumulation of Fcepsilonri on the cell surface

31 March 2020

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Regulation of mast cell survival by IgE

31 March 2020

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Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival

31 March 2020

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Regulation and function of mast cell proteases in inflammation

31 March 2020

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Identification of a committed precursor for the mast cell lineage.

31 March 2020

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Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites

31 March 2020

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Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice

31 March 2020

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Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

31 March 2020

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Distinct patterns of early response gene expression and proliferation in mouse mast cells stimulated by stem cell factor, interleukin-3, or IgE and antigen

31 March 2020

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Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc epsilon RI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells

31 March 2020

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Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation

31 March 2020

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Combined stimulation with the T helper cell type 2 cytokines interleukin (IL)-4 and IL-10 induces mouse mast cell apoptosis

31 March 2020

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Receptor-induced death in human natural killer cells: involvement of CD16.

31 March 2020

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Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

31 March 2020

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Cytokine production by mast cells and basophils

31 March 2020

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Mast-cell-leukocyte cytokine cascades in allergic inflammation

31 March 2020

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Fas ligand (FasL, CD95L, APO-1L) expression in murine mast cells

31 March 2020

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Regulation of apoptosis in mast cells

31 March 2020

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

31 March 2020

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

31 March 2020

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Regulation of cell death protease caspase-9 by phosphorylation

31 March 2020

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Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt.

31 March 2020

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Negative regulation of the forkhead transcription factor FKHR by Akt.

31 March 2020

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

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SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

31 March 2020

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Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk

31 March 2020

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Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity

31 March 2020

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Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement

31 March 2020

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Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation

31 March 2020

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Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes

31 March 2020

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Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

31 March 2020

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Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products.

31 March 2020

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Calcium, calcineurin, and the control of transcription

31 March 2020

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Effects of cyclosporin A and FK-506 on stem cell factor-induced histamine secretion and growth of human mast cells

31 March 2020

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A Role for Bax in the Regulation of Apoptosis in Mouse Mast Cells

31 March 2020

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Characterization of a mast cell line that lacks the extracellular domain of membrane c-kit

31 March 2020

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Active anaphylaxis in IgE-deficient mice

31 March 2020

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Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivo

31 March 2020

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Crohn's disease: transmission electron microscopic studies. II. Immunologic inflammatory response. Alterations of mast cells, basophils, eosinophils, and the microvasculature

31 March 2020

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The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology

31 March 2020

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Essential role for Gab2 in the allergic response

31 March 2020

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Akt signaling: linking membrane events to life and death decisions

31 March 2020

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Mechanisms and consequences of activation of protein kinase B/Akt

31 March 2020

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Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

31 March 2020

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Regulation of Btk function by a major autophosphorylation site within the SH3 domain

31 March 2020

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Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function

31 March 2020

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Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

31 March 2020

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Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

31 March 2020

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

31 March 2020

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LAT is essential for Fc(epsilon)RI-mediated mast cell activation

31 March 2020

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p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

31 March 2020

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

31 March 2020

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The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI914

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5 August 2017

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PubMed ID

12360215