Relationship between Thyrotropin Receptor Hinge Region Proteolytic Posttranslational Modification and Receptor Physiological Function (Q34942963)

5 August 2017

title

Relationship between thyrotropin receptor hinge region proteolytic posttranslational modification and receptor physiological function (English)

1 reference

https://api.crossref.org/works/10.1210/ME.2010-0401

5 August 2017

Relationship between Thyrotropin Receptor Hinge Region Proteolytic Posttranslational Modification and Receptor Physiological Function (English)

1 reference

2 September 2024

1 reference

post-translational protein modification

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21106880

2 September 2024

5

Basil Rapoport

1 reference

5 August 2017

Sepehr Hamidi

1

1 reference

5 August 2017

Chun-Rong Chen

series ordinal

2

1 reference

5 August 2017

Yumiko Mizutori-Sasai

series ordinal

3

1 reference

5 August 2017

Sandra M. McLachlan

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21106880

2 September 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21106880

2 September 2024

publication date

24 November 2010

1 reference

full work available at URL

5 August 2017

https://europepmc.org/articles/pmc3089032

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21106880

http://intl-mend.endojournals.org/cgi/content/abstract/25/1/184

2 September 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21106880

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21106880/?tool=EBI

2 September 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21106880

https://europepmc.org/articles/PMC3089032

2 September 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21106880

https://doi.org/10.1210/me.2010-0401

2 September 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21106880

http://academic.oup.com/mend/article-pdf/25/1/184/10722251/mend0184.pdf

2 September 2024

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1210/ME.2010-0401

2 September 2024

published in

Molecular Endocrinology

1 reference

5 August 2017

volume

25

1 reference

5 August 2017

issue

1

1 reference

5 August 2017

page(s)

184-194

1 reference

Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation

5 August 2017

cites work

1 reference

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The hinge region: an important receptor component for GPHR function.

8 July 2018

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Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms

8 July 2018

1 reference

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The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089032

Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody

8 July 2018

1 reference

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Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor

8 July 2018

1 reference

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Structure of human follicle-stimulating hormone in complex with its receptor

8 July 2018

1 reference

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Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface

8 July 2018

1 reference

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Model of glycoprotein hormone receptor ligand binding and signaling

8 July 2018

1 reference

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The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim

8 July 2018

1 reference

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Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089032

On the functional importance of thyrotropin receptor intramolecular cleavage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089032

The shed thyrotropin receptor is primarily a carboxyl terminal truncated form of the A subunit, not the entire A subunit

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089032

Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089032

An N-linked glycosylation motif from the noncleaving luteinizing hormone receptor substituted for the homologous region (Gly367 to Glu369) of the thyrotropin receptor prevents cleavage at its second, downstream site

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089032

Evidence that the thyrotropin receptor ectodomain contains not one, but two, cleavage sites

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089032

Cloning and functional expression of the luteinizing hormone receptor complementary deoxyribonucleic acid from the marmoset monkey testis: absence of sequences encoding exon 10 in other species

8 July 2018

1 reference

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Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089032

Extracellular domain chimeras of the TSH and LH/CG receptors reveal the mid-region (amino acids 171-260) to play a vital role in high affinity TSH binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089032

An insertion in the human thyrotropin receptor critical for high affinity hormone binding

8 July 2018

1 reference

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Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor function

8 July 2018

1 reference

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A New Structural Model for the Thyrotropin (TSH) Receptor, as Determined by Covalent Cross-Linking of TSH to the Recombinant Receptor in Intact Cells: Evidence for a Single Polypeptide Chain

8 July 2018

1 reference

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Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains

8 July 2018

1 reference

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Role of the carboxyl-terminal half of the extracellular domain of the human thyrotropin receptor in signal transduction

8 July 2018

1 reference

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Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation.

8 July 2018

1 reference

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Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity.

26 October 2018

1 reference

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Evidence that cleavage of the thyrotropin receptor involves a "molecular ruler" mechanism: deletion of amino acid residues 305-320 causes a spatial shift in cleavage site 1 independent of amino acid motif

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089032

Subunit structure of thyrotropin receptors expressed on the cell surface

26 October 2018

1 reference

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The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies

26 October 2018

1 reference

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Four families with loss of function mutations of the thyrotropin receptor

26 October 2018

1 reference

12 December 2020

Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist

1 reference

12 December 2020

Sequential cleavage and excision of a segment of the thyrotropin receptor ectodomain

1 reference

12 December 2020

Post-translational processing of the natural human thyrotropin receptor: demonstration of more than two cleavage sites

1 reference

12 December 2020

GRIS: glycoprotein-hormone receptor information system

1 reference

12 December 2020

Identifiers

DOI

10.1210/ME.2010-0401

1 reference

5 August 2017

1 reference

5 August 2017

1 reference