Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics (Q35003666)

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English	Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics	scientific article

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2 February 2020

Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics (English)

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2 February 2020

acute myeloid leukemia

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based on heuristic

inferred from title

pharmacodynamics

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based on heuristic

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Leanne A Flye-Blakemore

13

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2 February 2020

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2 February 2020

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Volker Wacheck

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2 February 2020

Michael Lahn

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2 February 2020

Gemma Dickinson

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2 February 2020

Wolfgang Füreder

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2 February 2020

Renata Meyer

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Susanne Herndlhofer

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2 February 2020

Thorsten Füreder

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Georg Dorfner

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Sada Pillay

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2 February 2020

Valérie André

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Timothy P Burkholder

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2 February 2020

Jacqueline K Akunda

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2 February 2020

Dirk Van Bockstaele

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2 February 2020

Richard F Schlenk

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2 February 2020

Wolfgang R Sperr

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2 February 2020

language of work or name

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publication date

10 May 2011

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2 February 2020

Cancer Management and Research

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2 February 2020

3

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2 February 2020

157-175

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2 February 2020

Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model.

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8 July 2018

Patient-derived acute myeloid leukemia (AML) bone marrow cells display distinct intracellular kinase phosphorylation patterns.

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8 July 2018

Use of artificial stomach-duodenum model for investigation of dosing fluid effect on clinical trial variability

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8 July 2018

Targeting multiple kinase pathways: a change in paradigm

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8 July 2018

Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia

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8 July 2018

Safety of multi-targeted kinase inhibitors as monotherapy treatment of cancer: a systematic review of the literature

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Functional proteomic profiling of AML predicts response and survival

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8 July 2018

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FLT3 kinase inhibitors in the management of acute myeloid leukemia.

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Drug-induced QTc interval prolongation: a proposal towards an efficient and safe anticancer drug development.

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Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

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Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics

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A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy

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8 July 2018

Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

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Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

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8 July 2018

The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo

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8 July 2018

Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors.

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A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease

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8 July 2018

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Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor

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The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo

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8 July 2018

Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways

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8 July 2018

Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

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8 July 2018

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International Conference on Harmonisation; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; availability. Notice.

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26 October 2018

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26 October 2018

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26 October 2018

An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients.

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26 October 2018

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26 October 2018

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26 October 2018

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26 October 2018

VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition

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26 October 2018

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26 October 2018

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

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26 October 2018

A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia

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9 December 2018

Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)

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12 December 2020

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Single cell analysis of phosphoinositide 3-kinase/Akt and ERK activation in acute myeloid leukemia by flow cytometry

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12 December 2020

based on heuristic

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Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome

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https://pubmed.ncbi.nlm.nih.gov/21625399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of risk group stratification in elderly patients with acute myeloid leukaemia

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An FLT3 gene-expression signature predicts clinical outcome in normal karyotype AML

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2147/CMR.S19341

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625399%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

release_dghrdsmga5cibnjvmeepzzxvh4

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https://api.fatcat.wiki/v0/release/dghrdsmga5cibnjvmeepzzxvh4

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625399%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625399%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

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