Targeting multiple kinase pathways: a change in paradigm (Q37705694)

22 August 2017

1 reference

title

Targeting multiple kinase pathways: a change in paradigm (English)

1 reference

22 August 2017

Lucy Gossage

1

1 reference

22 August 2017

Tim Eisen

series ordinal

2

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22 August 2017

language of work or name

English

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publication date

9 March 2010

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22 August 2017

Clinical Cancer Research

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22 August 2017

16

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22 August 2017

7

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22 August 2017

1973-1978

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Targeting the phosphoinositide 3-kinase pathway in cancer

22 August 2017

1 reference

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

23 August 2017

1 reference

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Targeting the mTOR signaling network for cancer therapy

23 August 2017

1 reference

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

23 August 2017

1 reference

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Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study

23 August 2017

1 reference

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Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma.

23 August 2017

1 reference

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Resistance to EGF-R (erbB-1) and VEGF-R modulating agents

23 August 2017

1 reference

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A phase II trial of erlotinib in combination with bevacizumab in patients with metastatic breast cancer

23 August 2017

1 reference

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

23 August 2017

1 reference

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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

23 August 2017

1 reference

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Detection of mutations in EGFR in circulating lung-cancer cells

23 August 2017

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Combined targeting of EGFR-dependent and VEGF-dependent pathways: rationale, preclinical studies and clinical applications

23 August 2017

1 reference

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Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia

23 August 2017

1 reference

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Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia

23 August 2017

1 reference

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

23 August 2017

1 reference

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Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

23 August 2017

1 reference

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The role of VEGF receptors in angiogenesis; complex partnerships

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

23 August 2017

1 reference

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The biology and clinical relevance of the PTEN tumor suppressor pathway

23 August 2017

1 reference

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High frequency of mutations of the PIK3CA gene in human cancers

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs

23 August 2017

1 reference

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Tangled webs: evidence of cross-talk between c-Raf-1 and Akt.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Phosphatidylinositol-3-OH kinase as a direct target of Ras

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy

23 August 2017

1 reference

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Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Phase II study of sunitinib administered in a continuous once-daily dosing regimen in patients with cytokine-refractory metastatic renal cell carcinoma

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Sequential sorafenib and sunitinib for renal cell carcinoma.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase ii study

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Sequential therapy with sorafenib and sunitinib in renal cell carcinoma

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Erlotinib plus bevacizumab in previously treated patients with malignant pleural mesothelioma

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Vatalanib (PTK787/ZK 222584) in combination with FOLFOX4 versus FOLFOX4 alone as first-line treatment for colorectal cancer: preliminary results from the CONFIRM-1 trial.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875112

Phase II study of FOLFOX, bevacizumab and erlotinib as first-line therapy for patients with metastatic colorectal cancer

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20215532

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20215532

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1078-0432.CCR-09-3182

1 reference

22 August 2017

1 reference

22 August 2017

PubMed publication ID

20215532

1 reference