3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio (Q35004902)

5 August 2017

3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio (English)

1 reference

5 August 2017

6

Kerry L McPhail

1 reference

5 August 2017

Yueying Zhen

1

1 reference

5 August 2017

Ondrej Slanar

2

1 reference

5 August 2017

Kristopher W Krausz

3

1 reference

5 August 2017

Chi Chen

4

1 reference

5 August 2017

Josef Slavík

5

1 reference

5 August 2017

T Mark Zabriskie

7

1 reference

5 August 2017

Frantisek Perlík

8

1 reference

5 August 2017

Frank J Gonzalez

9

1 reference

5 August 2017

Jeffrey R Idle

10

1 reference

5 August 2017

16 June 2006

1 reference

Drug Metabolism and Disposition

5 August 2017

1 reference

5 August 2017

34

1 reference

5 August 2017

9

1 reference

5 August 2017

1563-1574

1 reference

Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.

5 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Comparison of substrate metabolism by wild type CYP2D6 protein and a variant containing methionine, not valine, at position 374.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Nortriptyline and debrisoquine hydroxylations in Ghanaian and Swedish subjects.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Clinical evaluation of the antihypertensive effects of debrisoquin, a new postganglionic vasodepressor agent

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Prediction of creatinine clearance from serum creatinine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Proceedings: A correlation between the response to debrisoquine and the amount of unchanged drug excreted in the urine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Gas-liquid chromatographic electron capture determination of some monosubstituted guanido-containing drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Metabolism of debrisoquine sulphate in rat, dog and man

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

The metabolism of [14C]-debrisoquine in man

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Metabolism of debrisoquine sulfate. Identification of some urinary metabolites in rat and man

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Polymorphic hydroxylation of Debrisoquine in man.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Optimized Strategy for Rapid Cytochrome P450 2D6 Genotyping by Real-Time Long PCR

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

A study of the debrisoquine hydroxylation polymorphism in a Nigerian population

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

Genetic polymorphism of phenformin 4-hydroxylation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1553181

A clinical evaluation of debrisoquine sulphate

26 October 2018

1 reference

12 December 2020

Debrisoquin hydroxylation polymorphism among Ghanaians and Caucasians

1 reference

12 December 2020

The metabolism of debrisoquine in rat and man

1 reference

12 December 2020

Proceedings: N-oxidation of sparteine in man and its interindividual differences

1 reference

12 December 2020

Clinical Evaluation of Debrisoquin in the Treatment of Hypertension

1 reference

12 December 2020

Debrisoquin sulfate: a clinical evaluation of a new antihypertensive agent

1 reference

12 December 2020

E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylation

1 reference

12 December 2020

Comparative pharmacogenetics of sparteine and debrisoquine

1 reference

12 December 2020

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

1 reference

12 December 2020

Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers

1 reference

12 December 2020

Lack of relationship between tolbutamide metabolism and debrisoquine oxidation phenotype

1 reference

12 December 2020

Ifosfamide plasma clearance in relation to polymorphic debrisoquine oxidation

1 reference

12 December 2020

Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes

1 reference

12 December 2020

Short communication. The effects of drinking and smoking on the CYP2D6 metabolic capacity

1 reference

12 December 2020

1- and 3-hydroxylations, in addition to 4-hydroxylation, of debrisoquine are catalyzed by cytochrome P450 2D6 in humans

1 reference

12 December 2020

Mechanism of cytochrome P450 2D6-catalyzed sparteine metabolism in humans

1 reference

12 December 2020

Oxidative metabolism of zolpidem by human liver cytochrome P450S

1 reference

12 December 2020

Identifiers

DOI

10.1124/DMD.105.008920

1 reference

release_qxfenivlmvbz5pcqaxubaq2eku

5 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qxfenivlmvbz5pcqaxubaq2eku

24 November 2022

mapped directly with Wikidata item

PMCID

1553181

1 reference

5 August 2017

1 reference