Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease (Q35008186)

5 August 2017

title

Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease (English)

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5 August 2017

9

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Spiros Artavanis-Tsakonas

5 August 2017

14

Cenk Ayata

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object named as

Spyros Artavanis-Tsakonas

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5 August 2017

Jeong Hyun Lee

3

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Steven P. Gygi

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object named as

Steven Gygi

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5 August 2017

6

Charles R Vanderburg

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7

Matthew P Frosch

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5 August 2017

author name string

Joseph F Arboleda-Velasquez

1

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5 August 2017

Jan Manent

2

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5 August 2017

Saara Tikka

4

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5 August 2017

Carolina Ospina

5

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5 August 2017

Manuel Rodríguez-Falcón

8

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5 August 2017

Francisco Lopera

11

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5 August 2017

Hannu Kalimo

12

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5 August 2017

Michael A Moskowitz

13

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Angeliki Louvi

15

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5 August 2017

language of work or name

English

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publication date

9 May 2011

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Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

published in

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5 August 2017

volume

108

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5 August 2017

issue

21

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5 August 2017

page(s)

E128-35

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Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment

5 August 2017

cites work

1 reference

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8 July 2018

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8 July 2018

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8 July 2018

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Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain

8 July 2018

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Living beyond our physiological means: small vessel disease of the brain is an expression of a systemic failure in arteriolar function: a unifying hypothesis

8 July 2018

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Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients

8 July 2018

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8 July 2018

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8 July 2018

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The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

8 July 2018

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CADASIL-causing mutations do not alter Notch3 receptor processing and activation

8 July 2018

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CADASIL: a critical look at a Notch disease

8 July 2018

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8 July 2018

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The spectrum of mutations for CADASIL diagnosis

8 July 2018

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Notch3 is required for arterial identity and maturation of vascular smooth muscle cells

8 July 2018

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CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk

8 July 2018

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8 July 2018

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Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

8 July 2018

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A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.

8 July 2018

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8 July 2018

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CADASIL Notch3 mutant proteins localize to the cell surface and bind ligand

8 July 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

8 July 2018

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The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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21 January 2018

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21 January 2018

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Autosomal dominant leukoencephalopathy and subcortical ischemic stroke. A clinicopathological study

21 January 2018

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C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke

21 January 2018

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Case records of the Massachusetts General Hospital. Case 12-2009. A 46-year-old man with migraine, aphasia, and hemiparesis and similarly affected family members

21 January 2018

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Detection of the founder effect in Finnish CADASIL families

21 January 2018

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Genetic, clinical and pathological studies of CADASIL in Japan: a partial contribution of Notch3 mutations and implications of smooth muscle cell degeneration for the pathogenesis

21 January 2018

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Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype

21 January 2018

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Notch3 ectodomain is a major component of granular osmiophilic material (GOM) in CADASIL

21 January 2018

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Morphometric analysis of ultrastructural vascular changes in CADASIL: analysis of 50 skin biopsy specimens and pathogenic implications

26 October 2018

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26 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21555590

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1101964108

1 reference

5 August 2017

0 references

1 reference

5 August 2017

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