A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling. (Q24544042)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Gavin Chapman

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Urban Lendahl

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

author name string

Paul Beatus

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Karin Dannaeus

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Johan Lundkvist

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

language of work or name

English

0 references

publication date

13 December 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

15 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

volume

99

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

page(s)

17119-17124

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

issue

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

15 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

CADASIL: Notch signaling defect or protein accumulation problem?

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

The Notch1 receptor is cleaved constitutively by a furin-like convertase

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Notch signaling: cell fate control and signal integration in development

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Aggresomes: a cellular response to misfolded proteins

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Notch1 is required for the coordinate segmentation of somites

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

CADASIL Notch3 mutant proteins localize to the cell surface and bind ligand

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Notch receptor cleavage depends on but is not directly executed by presenilins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

The notch 3 intracellular domain represses notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Integration of endoplasmic reticulum signaling in health and disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Unilateral microfibrillar abnormalities in a case of asymmetric Marfan syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Multiple targets for brefeldin A.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139279

30 May 2018

Conformational disease

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.252624099

Mouse Notch 3 expression in the pre- and postnatal brain: relationship to the stroke and dementia syndrome CADASIL.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.252624099

Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.252624099

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12482954

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.252624099

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12482954%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference