Dual-specificity phosphatases as targets for antineoplastic agents (Q35013977)

5 August 2017

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title

Dual-specificity phosphatases as targets for antineoplastic agents (English)

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5 August 2017

4

John S Lazo

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5 August 2017

3

Peter Wipf

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5 August 2017

2

Alexander P Ducruet

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5 August 2017

Michael A Lyon

1

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5 August 2017

1 December 2002

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Nature Reviews Drug Discovery

5 August 2017

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5 August 2017

1

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5 August 2017

12

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5 August 2017

961-976

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https://scigraph.springernature.com/pub.10.1038/nrd963

5 August 2017

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Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C

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Multiple splicing variants of cdc25B regulate G2/M progression

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Kinetic analysis of the catalytic domain of human cdc25B.

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Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A

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Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25

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Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle

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The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase

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Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A

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The C-terminal tail of the dual-specificity Cdc25B phosphatase mediates modular substrate recognition

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Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradation

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Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.

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Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase

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Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

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Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

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14-3-3 proteins associate with cdc25 phosphatases

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Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation

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cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2

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Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase

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Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

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Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

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14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

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The Hallmarks of Cancer

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CDC25 phosphatases as potential human oncogenes

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Role of the Cdc25A phosphatase in human breast cancer

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Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas.

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Spatial analysis of key signaling proteins by high-content solid-phase cytometry in Hep3B cells treated with an inhibitor of Cdc25 dual-specificity phosphatases

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The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1

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Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition

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Total Synthesis of Dysidiolide

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Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor

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Identification of new Cdc25 dual specificity phosphatase inhibitors in a targeted small molecule array

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Generation of an Ugi library of phosphate mimic-containing compounds and identification of novel dual specific phosphatase inhibitors

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Naphthoquinone analogs as inactivators of cdc25 phosphatase

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Novel total synthesis of the anticancer natural product dysidiolide

31 March 2020

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Enantioselective formal total synthesis of (-)-dysidiolide

31 March 2020

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A formal total synthesis of the sesterterpenoid (+/-)-dysidiolide and approaches to the syntheses of (+/-)-6-epi-, (+/-)-15-epi-, and (+/-)-6,15-bisepidysidiolide

31 March 2020

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31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD963

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5 August 2017

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PubMed ID

12461518