Study of P450 function using gene knockout and transgenic mice (Q35015944)

5 August 2017

1 reference

title

Study of P450 function using gene knockout and transgenic mice (English)

1 reference

5 August 2017

Frank J Gonzalez

1

1 reference

PubMed ID

12464254

5 August 2017

Shioko Kimura

series ordinal

2

1 reference

PubMed ID

12464254

5 August 2017

language of work or name

English

0 references

publication date

1 January 2003

1 reference

Archives of Biochemistry and Biophysics

5 August 2017

1 reference

5 August 2017

409

1 reference

5 August 2017

1

1 reference

5 August 2017

153-158

1 reference

Genetic polymorphism and cancer risk

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Role of CYP2E1 in the hepatotoxicity of acetaminophen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Oligoglucoside elicitor-mediated activation of plant defense

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Mechanisms of hepatotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

A comprehensive approach for integration of toxicity and cancer risk assessments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Bioactivation of halogenated hydrocarbons by cytochrome P4502E1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Metabolism of Chloroform by Cytochrome P450 2E1 Is Required for Induction of Toxicity in the Liver, Kidney, and Nose of Male Mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Hepatic and pulmonary microsomal benzene metabolism in CYP2E1 knockout mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

The metabolism of xenobiotics to reactive electrophiles in chemical carcinogenesis and mutagenesis: a collaboration with Elizabeth Cavert Miller and our associates.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Immunohistochemical quantitation of 4-aminobiphenyl-DNA adducts and p53 nuclear overexpression in T1 bladder cancer of smokers and nonsmokers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Neonatal mouse assay for tumorigenicity: alternative to the chronic rodent bioassay.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Pharmacogenetic phenotyping and genotyping. Present status and future potential.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

From mouse to man: generating megabase chromosome rearrangements

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Functional expression and germline transmission of a human chromosome fragment in chimaeric mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Clozapine pharmacokinetics and pharmacodynamics studied with Cyp1A2-null mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

The role of cytochrome P450IIE1 in bioactivation of acetaminophen in diabetic and acetone-treated mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2802%2900364-8

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0003-9861(02)00364-8

1 reference

5 August 2017

1 reference

PubMed ID

12464254