Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: emergence of the gate theory of aging (Q35019556)

5 August 2017

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title

Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: emergence of the gate theory of aging (English)

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5 August 2017

Eui-Ju Yeo

1

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5 August 2017

Sang Chul Park

series ordinal

2

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5 August 2017

publication date

1 November 2002

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Mechanisms of Ageing and Development

5 August 2017

published in

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5 August 2017

volume

123

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5 August 2017

issue

12

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5 August 2017

page(s)

1563-1578

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Kinetics of 125I-PDGF binding and down-regulation of PDGF receptor in human arterial smooth muscle cell strains during cellular senescence in vitro

5 August 2017

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Age-dependent changes in the beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in human right atrium.

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7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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7 January 2021

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

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Impaired cAMP-mediated gene expression and decreased cAMP response element binding protein in senescent cells

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7 January 2021

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

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Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities

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Altered profile of transcription factor-binding activities in senescent human fibroblasts

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7 January 2021

Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein

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7 January 2021

Mechanism of enhanced cyclic AMP stimulation by isoproterenol in aged human fibroblasts

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7 January 2021

p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53

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7 January 2021

Oxidants, oxidative stress and the biology of ageing

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7 January 2021

EGF- and PDGF-stimulated phosphorylation in young and senescent WI-38 cells

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7 January 2021

Activities of 3′:5′ cyclic nucleotide phosphodiesterases in the superior cervical ganglion of rat: Characterization, compartmentalization and observations in young and old animals

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7 January 2021

Reduced cAMP-dependent phosphorylation in striatum and nucleus accumbens of aged rats: evidence of an altered functioning of D1 dopaminoceptive neurons

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7 January 2021

Effects of aging on signal transmission and transduction systems in the gerbil brain: morphological and autoradiographic study

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7 January 2021

beta-Adrenergic and muscarinic receptor expression are regulated in opposite ways during senescence in rat left ventricle

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7 January 2021

Inhibition of lipolysis by adenosine is potentiated with age

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7 January 2021

Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young, normal aged and Alzheimer donors

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7 January 2021

Upregulation of functional ryanodine receptors during in vitro aging of human diploid fibroblasts

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7 January 2021

IP(3), IP(3) receptor, and cellular senescence

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7 January 2021

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7 January 2021

Effect of aging on EGF stimulated DNA synthesis and EGF receptor levels in primary cultured rat hepatocytes

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7 January 2021

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7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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7 January 2021

Changes in caveolin subtype protein expression in aging rat organs.

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7 January 2021

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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7 January 2021

c-Jun N-terminal kinase specifically phosphorylates p66ShcA at serine 36 in response to ultraviolet irradiation

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7 January 2021

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

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7 January 2021

G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

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7 January 2021

Defect in ERK2 and p54(JNK) activation in aging mouse splenocytes

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7 January 2021

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

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7 January 2021

Extended life-span and stress resistance in the Drosophila mutant methuselah

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7 January 2021

Increased level of cAMP-dependent protein kinase in aging human lung fibroblasts

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7 January 2021

Impairments in both p70 S6 kinase and extracellular signal-regulated kinase signaling pathways contribute to the decline in proliferative capacity of aged hepatocytes

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7 January 2021

Presence of Oxidized Cholesterol in Caveolae Uncouples Active Platelet-derived Growth Factor Receptors from Tyrosine Kinase Substrates

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7 January 2021

Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells

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7 January 2021

Decreased response to epidermal growth factor during cellular senescence in cultured human microvascular endothelial cells

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7 January 2021

Differential expression of type I, II, and V adenylyl cyclase gene in the postnatal developing rat brain.

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7 January 2021

Potentiated bradykinin-induced increase of 1,2-diacylglycerol generation and phospholipase D activity in human senescent fibroblasts

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7 January 2021

The p66shc adaptor protein controls oxidative stress response and life span in mammals

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7 January 2021

Modulation of phospholipase C pathway in rat cerebral cortex during aging

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7 January 2021

Decreased expression of the platelet-derived growth factor beta-receptor in fibroblasts from a patient with Werner's syndrome

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7 January 2021

Age and gender influence muscle sympathetic nerve activity at rest in healthy humans.

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7 January 2021

Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Age-dependent decline in mitogenic stimulation of hepatocytes. Reduced association between Shc and the epidermal growth factor receptor is coupled to decreased activation of Raf and extracellular signal-regulated kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

p19ARF links the tumour suppressor p53 to Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Functional recovery of senescent cells through restoration of receptor-mediated endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Down-regulation of amphiphysin-1 is responsible for reduced receptor-mediated endocytosis in the senescent cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Down-regulation of receptor-mediated endocytosis is responsible for senescence-associated hyporesponsiveness.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Plasma membrane associated metabolic parameters and the aging of human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Effect of aging on cyclic AMP levels and adenylate cyclase and phosphodiesterase activities in the rat corpus striatum

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Aging affects epidermal growth factor receptor phosphorylation and traffic kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

G protein-dependent signalling and ageing.

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https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Alterations in myocardial signal transduction due to aging and chronic dynamic exercise

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7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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7 January 2021

Differential modulation of phospholipase D and phosphatidate phosphohydrolase during aging in rat cerebral cortex synaptosomes

1 reference

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7 January 2021

Clathrin-coated vesicle formation and protein sorting: an integrated process

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7 January 2021

Human ageing and the sympathoadrenal system

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7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Replicative senescence: implications for in vivo aging and tumor suppression

1 reference

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7 January 2021

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.

1 reference

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7 January 2021

1 reference

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7 January 2021

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1 reference

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7 January 2021

Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in HER-2 expression

1 reference

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7 January 2021

Changes in type VI adenylyl cyclase isoform expression correlate with a decreased capacity for cAMP generation in the aging ventricle.

1 reference

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7 January 2021

Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast.

1 reference

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7 January 2021

p53 mutant mice that display early ageing-associated phenotypes

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7 January 2021

Role of ceramide in cellular senescence

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7 January 2021

Phospholipase D in cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs

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https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Loss of functional caveolae during senescence of human fibroblasts

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7 January 2021

Studies on age-related changes in vascular smooth muscle and their Ca2+ mechanisms

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7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Deterioration of beta-adrenergic modulation of cardiovascular function with aging

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https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling

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7 January 2021

Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Senescence-like changes induced by hydroxyurea in human diploid fibroblasts

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https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Agonist-specific differential changes of cellular signal transduction pathways in senescent human diploid fibroblasts.

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7 January 2021

Senescence of human fibroblasts induced by oncogenic Raf.

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https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Levels of adenosine 3',5'-cyclic monophosphate in the cerebral cortex of aging rats

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https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Phosphodiesterase and adenyl-cyclase activities in the cerebral cortex of the aging rat

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https://api.crossref.org/works/10.1016%2FS0047-6374%2802%2900092-1

7 January 2021

Translocational inefficiency of intracellular proteins in senescence of human diploid fibroblasts

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7 January 2021

10.1016/S0047-6374(02)00092-1

Identifiers

DOI

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release_ocgq5e5oy5gmzltrp7ru2uosoi

5 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/ocgq5e5oy5gmzltrp7ru2uosoi

24 November 2022

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