mRNA display: from basic principles to macrocycle drug discovery (Q35025892)

5 August 2017

title

mRNA display: from basic principles to macrocycle drug discovery (English)

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5 August 2017

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3

Jack W Szostak

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5 August 2017

Kristopher Josephson

1

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5 August 2017

Alonso Ricardo

series ordinal

2

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5 August 2017

publication date

22 October 2013

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5 August 2017

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5 August 2017

volume

19

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5 August 2017

issue

4

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5 August 2017

page(s)

388-399

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Ribosomal synthesis of unnatural peptides

5 August 2017

cites work

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Fragment-based approaches in drug discovery and chemical biology

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Inefficient delivery but fast peptide bond formation of unnatural L-aminoacyl-tRNAs in translation

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Converting peptides into drug leads by lipidation

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Testing physical models of passive membrane permeation

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A simplified reconstitution of mRNA-directed peptide synthesis: activity of the epsilon enhancer and an unnatural amino acid

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Reevaluation of the D-amino acid compatibility with the elongation event in translation

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In vitro selection of multiple libraries created by genetic code reprogramming to discover macrocyclic peptides that antagonize VEGFR2 activity in living cells

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A novel strategy for in vitro selection of peptide-drug conjugates

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Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.

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Phage display for selection of novel binding peptides

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Fluorine in pharmaceuticals: looking beyond intuition

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A general route for post-translational cyclization of mRNA display libraries

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N-methylated cyclic pentaalanine peptides as template structures

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Ribosomal synthesis of dehydroalanine-containing peptides

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Histidine 66 in Escherichia coli elongation factor tu selectively stabilizes aminoacyl-tRNAs.

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Intestinal permeability of cyclic peptides: common key backbone motifs identified.

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Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition

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11 October 2022

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Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides

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11 October 2022

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Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

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In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors

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11 October 2022

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Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2.

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11 October 2022

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Diversity of monomers in nonribosomal peptides: towards the prediction of origin and biological activity.

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11 October 2022

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Cell-free translation reconstituted with purified components

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11 October 2022

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An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides

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11 October 2022

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The biosynthetic logic of polyketide diversity

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Effects of cyclic lipodepsipeptide structural modulation on stability, antibacterial activity, and human cell toxicity

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Ribosomal synthesis of polypeptoids and peptoid-peptide hybrids

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Messenger RNA-programmed incorporation of multiple N-methyl-amino acids into linear and cyclic peptides

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Ribosome-catalyzed polyester formation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

A facile strategy for selective incorporation of phosphoserine into histones.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Flexizymes for genetic code reprogramming

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

In vitro selection of anti-Akt2 thioether-macrocyclic peptides leading to isoform-selective inhibitors.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2013.10.011

Identifiers

DOI

10.1016/J.DRUDIS.2013.10.011

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5 August 2017

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