N-methylation of peptides and proteins: an important element for modulating biological functions (Q38060675)

28 August 2017

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title

N-methylation of peptides and proteins: an important element for modulating biological functions (English)

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28 August 2017

Jayanta Chatterjee

1

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28 August 2017

Florian Rechenmacher

series ordinal

2

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28 August 2017

Horst Kessler

series ordinal

3

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28 August 2017

language of work or name

English

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publication date

19 November 2012

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Angewandte Chemie International Edition

28 August 2017

published in

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volume

52

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28 August 2017

issue

1

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28 August 2017

page(s)

254-269

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Epigenetics: a landscape takes shape

28 August 2017

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N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis

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Identification of protein N-terminal methyltransferases in yeast and humans

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Protein arginine methylation in mammals: who, what, and why

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JMJD6 is a histone arginine demethylase

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Translating the Histone Code

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Chemical approaches to understand the language of histone modifications

21 January 2018

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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

21 January 2018

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Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail

21 January 2018

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Molecular biology of Fusarium mycotoxins

21 January 2018

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Investigation of the electrophysiological properties of enniatins.

21 January 2018

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Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells.

21 January 2018

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Apoptosis induced by enniatins H and MK1688 isolated from Fusarium oxysporum FB1501.

21 January 2018

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Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae

21 January 2018

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An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones

21 January 2018

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Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges.

21 January 2018

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Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin

21 January 2018

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Microtubules as a target for anticancer drugs

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Mode of action of thiocoraline, a natural marine compound with anti-tumour activity

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

NMe amide as a synthetic surrogate for the thioester moiety in thiocoraline

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Interaction of an echinomycin–DNA complex with manganese ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

DNA intercalator korkormicin A preferentially kills tumor cells expressing wild type p53.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Bouvardin and deoxybouvardin, antitumor cyclic hexapeptides from Bouvardia ternifolia (Rubiaceae)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Structure refinement of cyclosporin A in chloroform by using RDCs measured in a stretched PDMS-gel

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Isotope-edited NMR of cyclosporin A bound to cyclophilin: evidence for a trans 9,10 amide bond.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

The NMR structure of cyclosporin A bound to cyclophilin in aqueous solution

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

NMR studies of [U-13C]cyclosporin A bound to cyclophilin: bound conformation and portions of cyclosporin involved in binding

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Cyclosporin A-cyclophilin complex formation. A model based on X-ray and NMR data

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

21 January 2018

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Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design

21 January 2018

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N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

21 January 2018

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Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Bioactive peptides and depsipeptides with anticancer potential: sources from marine animals

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Cyclodepsipeptides from marine sponges: natural agents for drug research

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Phase II clinical and pharmacokinetic study of plitidepsin 3-hour infusion every two weeks alone or with dexamethasone in relapsed and refractory multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Phase II study of plitidepsin 3-hour infusion every 2 weeks in patients with unresectable advanced medullary thyroid carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Phase II study of biweekly plitidepsin as second-line therapy for advanced or metastatic transitional cell carcinoma of the urothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Phase II study of biweekly plitidepsin as second-line therapy in patients with advanced malignant melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Phase II randomized study of Plitidepsin (Aplidin), alone or in association with L-carnitine, in patients with unresectable advanced renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Efficient induction of apoptosis by ONYX-015 adenovirus in human colon cancer cell lines regardless of p53 status

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Phase II trials of dolastatin-10 in advanced pancreaticobiliary cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Exploiting cross-amyloid interactions to inhibit protein aggregation but not function: nanomolar affinity inhibition of insulin aggregation by an IAPP mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Biosynthesis of nonribosomal peptides1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Nonribosomal peptides: from genes to products

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Multifunctional Peptide Synthetases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Synthetic preparation of N-methyl-alpha-amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Cysteine-S-trityl a key derivative to prepare N-methyl cysteines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Optimized selective N-methylation of peptides on solid support

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Solid-phase synthesis and characterization of N-methyl-rich peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Deletion of Ac-NMePhe(1) from [NMePhe(1) ]arodyn under acidic conditions, part 1: effects of cleavage conditions and N-terminal functionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Solid-phase synthesis of NMe-IB-01212, a highly N-methylated cyclic peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Total synthesis of cyclosporine: access to N-methylated peptides via isonitrile coupling reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Transformation of aminoacyl tRNAs for the in vitro selection of "drug-like" molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Rethinking amide bond synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Ribosomal synthesis of N-methyl peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

A highly flexible tRNA acylation method for non-natural polypeptide synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

An unfolded CH1 domain controls the assembly and secretion of IgG antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Can N-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Molecular properties that influence the oral bioavailability of drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Amino acid side chain conformation in angiotensin II and analogs: correlated results of circular dichroism and 1H nuclear magnetic resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

N-methylated cyclic pentaalanine peptides as template structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Conformational preference and potential templates of N-methylated cyclic pentaalanine peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Identification of Sansalvamide a analog potent against pancreatic cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Comprehensive study of sansalvamide A derivatives and their structure-activity relationships against drug-resistant colon cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Multiple N-methylation by a designed approach enhances receptor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Assembly of the tight junction: the role of diacylglycerol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: application to prediction of Caco-2 cell permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

The effect of multiple N-methylation on intestinal permeability of cyclic hexapeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Intestinal permeability of cyclic peptides: common key backbone motifs identified.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Convective solvent flow across the skin during iontophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Exploring biology with small organic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Chemical genetics: ligand-based discovery of gene function

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Cell-penetrating peptides.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

The Conformation ofcyclo(−d-Pro−Ala4−) as a Model for Cyclic Pentapeptides of thedL4Type

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Hemiasterlin and geodiamolide TA; two new cytotoxic peptides from the marine sponge Hemiasterella minor (Kirkpatrick)

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201205674

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201205674

Thiocoraline, a New Depsipeptide with Antitumor Activity Produced by a Marine Micromonospora. I. Taxonomy, Fermentation, Isolation, and Biological Activities.

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.50.734

Identifiers

DOI

10.1002/ANIE.201205674

1 reference

release_lesj4x2hdrdrdl3hwex3u5z7zy

28 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lesj4x2hdrdrdl3hwex3u5z7zy

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference