Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression (Q35028164)

5 August 2017

title

Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression (English)

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5 August 2017

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Dongdong Lu

1

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5 August 2017

Chang Han

series ordinal

2

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5 August 2017

Tong Wu

series ordinal

3

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5 August 2017

language of work or name

English

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publication date

24 February 2011

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5 August 2017

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5 August 2017

volume

140

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5 August 2017

issue

7

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5 August 2017

page(s)

2084-2094

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Subtle variations in Pten dose determine cancer susceptibility

5 August 2017

cites work

1 reference

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PTEN regulation by Akt-EGR1-ARF-PTEN axis

8 July 2018

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Tenets of PTEN tumor suppression

8 July 2018

1 reference

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Membrane prostaglandin E synthase-1: a novel therapeutic target

8 July 2018

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MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

8 July 2018

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Defining the role of mTOR in cancer

8 July 2018

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A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas.

8 July 2018

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

8 July 2018

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Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice

8 July 2018

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Prostaglandin E synthase: a novel drug target for inflammation and cancer

8 July 2018

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Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

8 July 2018

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Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Cyclooxygenase-2 and prostaglandin signaling in cholangiocarcinoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.

8 July 2018

1 reference

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Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy

8 July 2018

1 reference

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Analysis of the glutathione S-transferase (GST) gene family

8 July 2018

1 reference

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The biology and clinical relevance of the PTEN tumor suppressor pathway

8 July 2018

1 reference

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The molecular pathogenesis of cholangiocarcinoma

8 July 2018

1 reference

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The epidemiology of cholangiocarcinoma

8 July 2018

1 reference

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Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Cyclooxygenase-2 promotes human cholangiocarcinoma growth: evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Cholangiocarcinoma: Current concepts and insights

8 July 2018

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Cholangiocarcinoma: recent progress. Part 2: molecular pathology and treatment

8 July 2018

1 reference

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ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Aberrant cyclooxygenase isozyme expression in human intrahepatic cholangiocarcinoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Mechanisms and consequences of activation of protein kinase B/Akt

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Clinical trials. Nail-biting time for trials of COX-2 drugs

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Vioxx withdrawal alarms cancer prevention researchers

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Insulin-like growth factor-II regulates PTEN expression in the mammary gland.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9 and -3.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109169

25 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21354147

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of microsomal prostaglandin E synthase-1 in human hepatocelluar carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21354147

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1053/J.GASTRO.2011.02.056

1 reference

5 August 2017

1 reference

5 August 2017

1 reference