Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells. (Q35032457)

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English	Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells.	scientific article

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20 January 2020

Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21268136%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

colon carcinoma

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3

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20 January 2020

Robert Sclafani

4

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20 January 2020

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Manjinder Kaur

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20 January 2020

Alpna Tyagi

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20 January 2020

Rajesh Agarwal

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20 January 2020

Chapla Agarwal

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20 January 2020

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25 January 2011

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20 January 2020

Molecular Carcinogenesis

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20 January 2020

50

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20 January 2020

7

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20 January 2020

553-562

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20 January 2020

Role of oxidative stress and MAPK signaling in reference moist smokeless tobacco-induced HOK-16B cell death

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8 July 2018

Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response.

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8 July 2018

Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling

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The emerging complexity of protein ubiquitination

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Oxidative stress and thioredoxin system

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8 July 2018

Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype

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8 July 2018

CDK inhibitors: cell cycle regulators and beyond

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8 July 2018

Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase Cdelta-mediated phosphorylation

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8 July 2018

Histone deacetylase inhibitors: signalling towards p21cip1/waf1.

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8 July 2018

Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288).

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8 July 2018

Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells

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8 July 2018

Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells

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8 July 2018

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

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8 July 2018

Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor

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8 July 2018

p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110540

8 July 2018

p21 stability: linking chaperones to a cell cycle checkpoint

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8 July 2018

Redox activation of p21Cip1/WAF1/Sdi1: a multifunctional regulator of cell survival and death

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8 July 2018

To be or not to be ubiquitinated?

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8 July 2018

p21Waf1/Cip1 as a therapeutic target in breast and other cancers

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8 July 2018

p21/CDKN1A mediates negative regulation of transcription by p53.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3110540

8 July 2018

P21Waf1 control of epithelial cell cycle and cell fate

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8 July 2018

The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein

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8 July 2018

Effects of histone acetylation and DNA methylation on p21( WAF1) regulation

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8 July 2018

Safety evaluation of proanthocyanidin-rich extract from grape seeds

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8 July 2018

AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

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8 July 2018

Cyclin/Cdk complexes: their involvement in cell cycle progression and mitotic division

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8 July 2018

Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways

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8 July 2018

The functions of the cdk-cyclin kinase inhibitor p21WAF1.

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8 July 2018

Cell cycle control as a basis for cancer drug development (Review).

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8 July 2018

Microinjection of anti-p21 antibodies induces senescent Hs68 human fibroblasts to synthesize DNA but not to divide

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8 July 2018

Induction of apoptosis by the p53-273L (Arg --> Leu) mutant in HSC3 cells without transactivation of p21Waf1/Cip1/Sdi1 and bax.

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8 July 2018

CDK inhibitors: positive and negative regulators of G1-phase progression

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8 July 2018

Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells

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8 July 2018

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

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8 July 2018

p53-dependent elevation of p21Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system

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8 July 2018

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

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8 July 2018

WAF1/Cip1 gene polymorphism and expression in carcinomas of the breast, ovary, and endometrium

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8 July 2018

p21 is a universal inhibitor of cyclin kinases

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8 July 2018

Cyclin D1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms.

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21 January 2018

Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice.

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Transcriptional Regulation of the p21(WAF1/CIP1)Gene

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Redox-Mediated Regulation of p21Waf1/Cip1 Expression Involves a Post-Transcriptional Mechanism and Activation of the Mitogen-Activated Protein Kinase Pathway

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MEK1 is required for PDGF-induced ERK activation and DNA synthesis in tracheal myocytes

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Genistein exerts multiple suppressive effects on human breast carcinoma cells

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12 December 2020

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Venous invasion and down-regulation of p21(WAF1/CIP1) are associated with metastasis in colorectal carcinomas

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12 December 2020

based on heuristic

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Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation

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https://pubmed.ncbi.nlm.nih.gov/21268136

12 December 2020

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Association between polymorphism in p21(Waf1/Cip1) cyclin-dependent kinase inhibitor gene and human oral cancer

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12 December 2020

based on heuristic

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Absence of WAF1 mutations in a variety of human malignancies

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/MC.20739

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20 January 2020

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20 January 2020

PubMed publication ID

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20 January 2020

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