Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells (Q35034700)

5 August 2017

Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells (English)

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5 August 2017

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neoplastic stem cells

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Michele Cioffi

2

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Anamaria Balic

Anamaria Balic

7

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Patricia Sancho

Patricia Sancho

3

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Manuel Hidalgo

Manuel Hidalgo

8

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Christopher Heeschen

9

Christopher Heeschen

1 reference

5 August 2017

Yolanda Sanchez-Ripoll

4

Yolanda Sanchez-Ripoll

1 reference

5 August 2017

Enza Lonardo

1

1 reference

5 August 2017

Sara Maria Trabulo

5

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5 August 2017

Jorge Dorado

6

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5 August 2017

language of work or name

English

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publication date

18 October 2013

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5 August 2017

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5 August 2017

8

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5 August 2017

e76518

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5 August 2017

10

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Creative Commons Attribution 4.0 International

5 August 2017

start time

18 October 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells

8 July 2018

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Metformin use is associated with better survival of diabetic patients with pancreatic cancer

8 July 2018

1 reference

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Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

Diabetes and pancreatic cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction

8 July 2018

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Empowering self-renewal and differentiation: the role of mitochondria in stem cells

8 July 2018

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Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer.

8 July 2018

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8 July 2018

Cancer statistics, 2010

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8 July 2018

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Metformin and cancer: doses, mechanisms and the dandelion and hormetic phenomena

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma

8 July 2018

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Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.

8 July 2018

1 reference

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

8 July 2018

1 reference

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

8 July 2018

1 reference

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Targeting the mTOR signaling network for cancer therapy

8 July 2018

1 reference

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A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development.

8 July 2018

1 reference

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Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

8 July 2018

1 reference

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No place like home: anatomy and function of the stem cell niche

8 July 2018

1 reference

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Epidemiology and risk factors for pancreatic cancer.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

Metformin and reduced risk of cancer in diabetic patients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

Epidemiology of pancreatic cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799760

Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0076518

Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0076518

An in vivo platform for translational drug development in pancreatic cancer

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24204632

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0076518

1 reference

5 August 2017

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5 August 2017

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