Mutant glucocerebrosidase in Gaucher disease recruits Hsp27 to the Hsp90 chaperone complex for proteasomal degradation (Q35037986)

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27 February 2020

title

Mutant glucocerebrosidase in Gaucher disease recruits Hsp27 to the Hsp90 chaperone complex for proteasomal degradation (English)

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27 February 2020

0 references

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1

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27 February 2020

Pauline Dmitriev

5

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27 February 2020

author name string

Herui Wang

2

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27 February 2020

Dongwang Zhu

3

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27 February 2020

Christopher S Hong

4

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27 February 2020

Chao Zhang

6

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27 February 2020

Yan Li

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27 February 2020

Barbara Ikejiri

8

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27 February 2020

Roscoe O Brady

9

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27 February 2020

Zhengping Zhuang

10

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27 February 2020

language of work or name

English

0 references

publication date

12 January 2015

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Proceedings of the National Academy of Sciences of the United States of America

27 February 2020

published in

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volume

112

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page(s)

1137-1142

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issue

4

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describes a project that uses

27 February 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4313839/fullTextXML

inferred from PubMed Central ID database lookup

cites work

ERdj3 is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease.

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Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTS

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Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones.

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The Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer

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Histone deacetylase inhibitors increase glucocerebrosidase activity in Gaucher disease by modulation of molecular chaperones

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Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function

8 July 2018

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Pharmacological chaperones facilitate the post-ER transport of recombinant N370S mutant β-glucocerebrosidase in plant cells: evidence that N370S is a folding mutant

8 July 2018

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β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas

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Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease

8 July 2018

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Missense mutations in the NF2 gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic function

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Chaperone Hsp27 modulates AUF1 proteolysis and AU-rich element-mediated mRNA degradation.

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Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl.

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Interaction between parkin and mutant glucocerebrosidase variants: a possible link between Parkinson disease and Gaucher disease

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HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells

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12 December 2020

inferred from PubMed ID database lookup

Characterization of the ERAD process of the L444P mutant glucocerebrosidase variant

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25583479

12 December 2020

inferred from PubMed ID database lookup

ITCH regulates degradation of mutant glucocerebrosidase: implications to Gaucher disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25583479

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1424288112

1 reference

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27 February 2020

0 references

1 reference

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27 February 2020

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