Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety. (Q35038572)

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English	Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety.	scientific article

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21548996%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21548996%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

phase I clinical trial

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phase II clinical trial

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1 reference

based on heuristic

inferred from title

pharmacokinetics

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based on heuristic

inferred from title

Satoshi Teramukai

5

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30 January 2020

10

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Tsutomu Chiba

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30 January 2020

author name string

Akio Ido

1

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30 January 2020

Akihiro Moriuchi

2

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30 January 2020

Masatsugu Numata

3

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30 January 2020

Toshinori Murayama

4

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30 January 2020

Hiroyuki Marusawa

6

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30 January 2020

Naohisa Yamaji

7

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30 January 2020

Hitoshi Setoyama

8

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30 January 2020

Il-Deok Kim

9

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30 January 2020

Shuji Higuchi

11

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30 January 2020

Masayuki Yokode

12

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30 January 2020

Masanori Fukushima

13

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30 January 2020

Akira Shimizu

14

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30 January 2020

Hirohito Tsubouchi

15

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30 January 2020

publication date

8 May 2011

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30 January 2020

Journal of Translational Medicine

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30 January 2020

9

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30 January 2020

55

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30 January 2020

copyright license

Creative Commons Attribution 2.0 Generic

8 May 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

1 reference

April 2022 Public Data File from Crossref

Etiology and prognosis of fulminant hepatitis in adults.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Acute liver failure: Summary of a workshop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Met provides essential signals for liver regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Additive and inhibitory effects of simultaneous treatment with growth factors on DNA synthesis through MAPK pathway and G1 cyclins in rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Acute liver failure: redefining the syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Human hepatocyte growth factor in plasma from patients with fulminant hepatic failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Clinical significance of human hepatocyte growth factor in blood from patients with fulminant hepatic failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Prediction of outcome in fulminant hepatic failure by serum human hepatocyte growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

8 July 2018

Fulminant hepatitis and late onset hepatic failure in Japan.

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-9-55

21 January 2018

Effects of high-volume plasmapheresis on ammonia, urea, and amino acids in patients with acute liver failure

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-9-55

21 January 2018

Hepatocyte growth factor accelerates the proliferation of hepatic oval cells and possibly promotes the differentiation in a 2-acetylaminofluorene/partial hepatectomy model in rats

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-9-55

21 January 2018

Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt.

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-9-55

21 January 2018

Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3k-Akt-dependent manner.

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-9-55

21 January 2018

Hepatocyte growth factor facilitates colonic mucosal repair in experimental ulcerative colitis in rats

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-9-55

21 January 2018

Hepatocyte growth factor reduces the infarct volume after transient focal cerebral ischemia in rats.

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-9-55

21 January 2018

Hepatocyte growth factor facilitates the repair of large colonic ulcers in 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-9-55

21 January 2018

Repeated intravenous injection of recombinant human hepatocyte growth factor ameliorates liver cirrhosis but causes albuminuria in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112439

25 October 2018

Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene transfection of hepatocyte growth factor attenuates reperfusion injury in the heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized controlled trial of lamivudine to treat acute hepatitis B

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomised trial of steroid therapy in acute liver failure. Report from the European Association for the Study of the Liver (EASL)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in liver regenerative factors in a case of living-related liver transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective action of hepatocyte growth factor for acute liver injury caused by D-galactosamine in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic study of recombinant human hepatocyte growth factor administered in a bolus intravenously or via portal vein

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of liver growth by exogenous human hepatocyte growth factor in normal and partially hepatectomized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1479-5876-9-55

1 reference

Europe PubMed Central

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30 January 2020

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30 January 2020

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30 January 2020

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