The mitochondrial theory of aging: involvement of mitochondrial DNA damage and repair (Q35038687)

5 August 2017

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title

The mitochondrial theory of aging: involvement of mitochondrial DNA damage and repair (English)

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5 August 2017

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2

Vilhelm A Bohr

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5 August 2017

Nadja C de Souza-Pinto

series ordinal

1

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5 August 2017

1 January 2002

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International Review of Neurobiology

5 August 2017

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5 August 2017

53

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5 August 2017

519-534

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Aging and proteolysis of oxidized proteins

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Measurement of oxidatively induced base lesions in liver from Wistar rats of different ages

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https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Mitochondrial endogenous oxidative damage has been overestimated

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https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Low mitochondrial free radical production per unit O2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Protein oxidation in aging, disease, and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

DNA damage, mutation and fine structure DNA repair in aging.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

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https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Reactions of oxyl radicals with DNA.

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https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Biochemistry of oxygen toxicity

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https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Mitochondrial free radical generation, oxidative stress, and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Protection of DNA damage by dietary restriction

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

An oxidative damage-specific endonuclease from rat liver mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Mitochondrial DNA repair pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

A putative gene causes variability in lifespan among genotypically identical mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Repair of oxidative damage to DNA: enzymology and biology

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Reconstitution of the DNA base excision-repair pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Purification of nuclear and mitochondrial uracil-DNA glycosylase from rat liver. Identification of two distinct subcellular forms.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Facile detection of mitochondrial DNA mutations in tumors and bodily fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Hydroxyl free radical adduct of deoxyguanosine: sensitive detection and mechanisms of formation

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Two Pathways for Base Excision Repair in Mammalian Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Mutagenesis by 8-oxoguanine: an enemy within

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Genetic pathways that regulate ageing in model organisms

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Nucleotide excision repair of actively transcribed versus nontranscribed DNA in rat hepatocytes: effect of age and dietary restriction

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Aging: a theory based on free radical and radiation chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

The biologic clock: the mitochondria?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Age-associated damage in mitochondrial DNA in human hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Quantification of oxidative DNA modifications in mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Purification of all forms of HeLa cell mitochondrial DNA and assessment of damage to it caused by hydrogen peroxide treatment of mitochondria or cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Age-associated change in mitochondrial DNA damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).dA(anti) alignment at lesion site

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

DNA glycosylases in the base excision repair of DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

The human DNA ligase III gene encodes nuclear and mitochondrial proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

1 reference

7 January 2021

Crystal structure of a DNA duplex containing 8-hydroxydeoxyguanine-adenine base pairs

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Mitochondrial role in cell aging

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Mutagenesis by hydrogen peroxide treatment of mammalian cells: a molecular analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Age-dependent decline in the cytochrome c oxidase activity in rat heart mitochondria: role of cardiolipin

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Efficient repair of abasic sites in DNA by mitochondrial enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Action of mitochondrial DNA polymerase gamma at sites of base loss or oxidative damage

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Somatic mutations of the mitochondrial genome in human colorectal tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Repair of DNA damage in a mitochondrial lysate of Xenopus laevis oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

DNA replication by a membrane-DNA complex from rat liver mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Mitochondrial DNA damage by anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Mitochondrial production of pro-oxidants and cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines. Do aldehydic by-products of lipid peroxidation contribute to oxidative stress?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Protein oxidation and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Age-associated damage in mitochondrial function in rat hearts

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Garbage catastrophe theory of aging: imperfect removal of oxidative damage?

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Nucleotide excision repair in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

Comparison of Oxidative Base Damage in Mitochondrial and Nuclear DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7742%2802%2953018-X

7 January 2021

10.1016/S0074-7742(02)53018-X

Identifiers

DOI

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5 August 2017

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PubMed ID

12512351