The HIV-1 Tat protein induces the activation of CD8+ T cells and affects in vivo the magnitude and kinetics of antiviral responses (Q35040673)

6 August 2017

title

The HIV-1 Tat protein induces the activation of CD8+ T cells and affects in vivo the magnitude and kinetics of antiviral responses (English)

1 reference

6 August 2017

Federica Destro

6

0 references

Francesco Nicoli

Francesco Nicoli

1

0 references

Peggy Marconi

Peggy Marconi

8

0 references

Antonella Caputo

Antonella Caputo

9

0 references

Riccardo Gavioli

Riccardo Gavioli

11

0 references

Barbara Ensoli

Barbara Ensoli

10

0 references

author name string

Valentina Finessi

2

1 reference

6 August 2017

Mariaconcetta Sicurella

3

1 reference

6 August 2017

Lara Rizzotto

4

1 reference

6 August 2017

Eleonora Gallerani

5

1 reference

6 August 2017

Aurelio Cafaro

7

1 reference

6 August 2017

language of work or name

English

0 references

publication date

4 November 2013

1 reference

6 August 2017

1 reference

6 August 2017

volume

8

1 reference

6 August 2017

issue

11

1 reference

6 August 2017

page(s)

e77746

1 reference

Creative Commons Attribution 4.0 International

6 August 2017

copyright license

start time

4 November 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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B cells in HIV infection and disease

8 July 2018

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Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes

8 July 2018

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Identification of new HIV-1 Gag-specific cytotoxic T lymphocyte responses in BALB/c mice.

8 July 2018

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Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.

8 July 2018

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Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival

8 July 2018

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Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation

8 July 2018

1 reference

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Plasmacytoid and myeloid dendritic cells with a partial activation phenotype accumulate in lymphoid tissue during asymptomatic chronic HIV-1 infection

8 July 2018

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Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

RCAS1 induced by HIV-Tat is involved in the apoptosis of HIV-1 infected and uninfected CD4+ T cells

8 July 2018

1 reference

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Mechanisms of CD4 T-cell depletion triggered by HIV-1 viral proteins

8 July 2018

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Signals required for programming effector and memory development by CD8+ T cells

8 July 2018

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Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.

8 July 2018

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

8 July 2018

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8 July 2018

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The multiple functions of HIV-1 Tat: proliferation versus apoptosis

8 July 2018

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8 July 2018

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HIV-1 tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity

21 January 2018

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Human immunodeficiency virus type 1 Tat protein modulates cell cycle and apoptosis in Epstein-Barr virus-immortalized B cells

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Generation of CD8(+) T cell memory in response to low, high, and excessive levels of epitope

8 July 2018

1 reference

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Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses

8 July 2018

1 reference

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Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

The density of peptides displayed by dendritic cells affects immune responses to human tyrosinase and gp100 in HLA-A2 transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

Human immunodeficiency virus type 1 tat protein activates transcription factor NF-kappaB through the cellular interferon-inducible, double-stranded RNA-dependent protein kinase, PKR

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

Interferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

Tat protein induces self-perpetuating permissivity for productive HIV-1 infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

HIV-1 Tat induces the expression of the interleukin-6 (IL6) gene by binding to the IL6 leader RNA and by interacting with CAAT enhancer-binding protein beta (NF-IL6) transcription factors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

The human immunodeficiency virus type 1 Tat protein transactivates tumor necrosis factor beta gene expression through a TAR-like structure.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

The trans-activator gene of HTLV-III is essential for virus replication

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817196

CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7.

8 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0077746

Antiretroviral therapy does not block the secretion of the human immunodeficiency virus tat protein.

21 January 2018

1 reference

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HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection

21 January 2018

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Development of herpes simplex virus replication-defective multigene vectors for combination gene therapy applications

21 January 2018

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21 January 2018

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Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction

21 January 2018

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Rapid functional exhaustion and deletion of CTL following immunization with recombinant adenovirus

21 January 2018

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Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0077746

Human immunodeficiency virus type 1 TAT protein activates B lymphocytes

21 January 2018

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Priming with a very low dose of DNA complexed with cationic block copolymers followed by protein boost elicits broad and long-lasting antigen-specific humoral and cellular responses in mice

21 January 2018

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The presence of anti-Tat antibodies is predictive of long-term nonprogression to AIDS or severe immunodeficiency: findings in a cohort of HIV-1 seroconverters

21 January 2018

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Early programming of T cell populations responding to bacterial infection

21 January 2018

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CD8+ T cell contraction is controlled by early inflammation.

21 January 2018

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The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes

21 January 2018

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Dysfunctional Epstein-Barr virus (EBV)-specific CD8(+) T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma

21 January 2018

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A systematic comparison of methods to measure HIV-1 specific CD8 T cells.

21 January 2018

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Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

21 January 2018

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Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo.

21 January 2018

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CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection

21 January 2018

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Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals

21 January 2018

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Cutting edge: HIV-1 Tat protein differentially modulates the B cell response of naive, memory, and germinal center B cells

21 January 2018

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The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells

25 October 2018

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Analysis of HSV isolated from patients with unilateral and bilateral herpetic keratitis

25 October 2018

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12 December 2020

Antibodies to Tat and Vpr in the GRIV cohort: differential association with maintenance of long-term non-progression status in HIV-1 infection

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12 December 2020

Candidate HIV-1 Tat vaccine development: from basic science to clinical trials

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12 December 2020

The Tat protein broadens T cell responses directed to the HIV-1 antigens Gag and Env: Implications for the design of new vaccination strategies against AIDS

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12 December 2020

Alterations in blood leucocyte adhesion molecule profiles in HIV-1 infection

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12 December 2020

Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway

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12 December 2020

Pleiotropic effects of immobilized versus soluble recombinant HIV-1 Tat protein on CD3-mediated activation, induction of apoptosis, and HIV-1 long terminal repeat transactivation in purified CD4+ T lymphocytes

1 reference

12 December 2020

High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0077746

Identifiers

DOI

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference