Blockade of the HERG human cardiac K(+) channel by the antidepressant drug amitriptyline (Q35042106)

6 August 2017

title

Blockade of the HERG human cardiac K(+) channel by the antidepressant drug amitriptyline (English)

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6 August 2017

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S H Jo

1

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6 August 2017

J B Youm

2

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6 August 2017

C O Lee

3

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6 August 2017

Y E Earm

4

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6 August 2017

W K Ho

5

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6 August 2017

language of work or name

English

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publication date

1 April 2000

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British Journal of Pharmacology

6 August 2017

published in

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6 August 2017

volume

129

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6 August 2017

issue

7

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6 August 2017

page(s)

1474-1480

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A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.

6 August 2017

cites work

1 reference

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A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes

8 July 2018

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The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes

8 July 2018

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HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine

8 July 2018

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High affinity open channel block by dofetilide of HERG expressed in a human cell line.

8 July 2018

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Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

8 July 2018

1 reference

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A family of potassium channel genes related to eag in Drosophila and mammals

8 July 2018

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A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

8 July 2018

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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

8 July 2018

1 reference

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HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

8 July 2018

1 reference

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Tricyclic medication in children and the QT interval: case report and discussion

8 July 2018

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Mechanisms of ventricular arrhythmia during amitriptyline toxicity.

8 July 2018

1 reference

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Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications

8 July 2018

1 reference

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The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels

8 July 2018

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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

8 July 2018

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Electrophysiologic effects of phenothiazines on canine cardiac fibers

8 July 2018

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Amitriptyline-induced Torsade de Pointes. Successful therapy with atrial pacing.

8 July 2018

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Discrepancies between pharmacokinetic studies of amitriptyline.

8 July 2018

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Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

8 July 2018

1 reference

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UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells.

8 July 2018

1 reference

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Clinical Features in Poisonings by Tricyclic Antidepressants with Special Reference to the ECG

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571977

Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs

8 July 2018

1 reference

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Mechanism of block of cardiac transient outward K+ current (I(to)) by antidepressant drugs.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571977

Blockade of the delayed rectifier K+ currents, IKr, in rabbit sinoatrial node cells by external divalent cations

25 October 2018

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12 December 2020

Tricyclic antidepressant overdose: incidence of symptoms

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12 December 2020

Relationship between age and tricyclic antidepressant plasma levels

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12 December 2020

The electrocardiographic and antiarrhythmic effects of imipramine hydrochloride at therapeutic plasma concentrations

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12 December 2020

Effect of imipramine on calcium and potassium currents in isolated bovine ventricular myocytes

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12 December 2020

Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence

1 reference

12 December 2020

Effects of imipramine and amitriptyline on intraventricular conduction, effective refractory period, incidence of ventricular arrhythmias induced by programmed stimulation, and on electrocardiogram after myocardial infarction in dog

1 reference

12 December 2020

Voltage- and time-dependent block of delayed rectifier K+ current in rabbit sino-atrial node cells by external Ca2+ and Mg2+

1 reference

12 December 2020

Differential effects of antiarrhythmic agents on post-pause repolarization in cardiac Purkinje fibres

1 reference

12 December 2020

Intracardiac conduction defects following overdose of tricyclic antidepressant drugs

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0703222

1 reference

release_c7n7id5o2zgbni2kapx237yrdy

6 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/c7n7id5o2zgbni2kapx237yrdy

24 November 2022

mapped directly with Wikidata item

PMC publication ID

1571977

1 reference

6 August 2017

1 reference