Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16. (Q35051547)

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English	Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16.	scientific article

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10 March 2020

Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16 (English)

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10 March 2020

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Akihide Yoshimi

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10 March 2020

Masahiro Nakagawa

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10 March 2020

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Koki Ueda

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10 March 2020

Yuki Kagoya

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10 March 2020

Satoshi Nishikawa

4

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10 March 2020

Victor E Marquez

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10 March 2020

Mineo Kurokawa

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10 March 2020

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30 March 2014

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10 March 2020

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10 March 2020

105

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10 March 2020

5

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10 March 2020

512-519

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10 March 2020

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Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317832

8 July 2018

Emerging epigenetic targets and therapies in cancer medicine

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8 July 2018

Polycomb repressive complex 2 is required for MLL-AF9 leukemia

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8 July 2018

Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence

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8 July 2018

AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors

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8 July 2018

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

1 reference

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8 July 2018

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

1 reference

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8 July 2018

The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML.

1 reference

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8 July 2018

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

1 reference

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8 July 2018

The role of HDACs inhibitors in childhood and adolescence acute leukemias

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8 July 2018

Key roles of histone methyltransferase and demethylase in leukemogenesis.

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8 July 2018

Dynamics of epigenetic modifications in leukemia

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8 July 2018

Vorinostat in acute myeloid leukemia and myelodysplastic syndromes

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8 July 2018

Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia

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8 July 2018

Epigenetic mechanisms regulating normal and malignant haematopoiesis: new therapeutic targets for clinical medicine.

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8 July 2018

SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia

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8 July 2018

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

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8 July 2018

The molecular biology of mixed lineage leukemia

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8 July 2018

DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation

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8 July 2018

BMI-1 expression is enhanced through transcriptional and posttranscriptional regulation during the progression of chronic myeloid leukemia

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8 July 2018

MLL translocations, histone modifications and leukaemia stem-cell development

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8 July 2018

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

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8 July 2018

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

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8 July 2018

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317832

8 July 2018

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

1 reference

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8 July 2018

Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

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8 July 2018

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

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8 July 2018

hDOT1L links histone methylation to leukemogenesis

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8 July 2018

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

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8 July 2018

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

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8 July 2018

The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias

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8 July 2018

The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3

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Plat-E: an efficient and stable system for transient packaging of retroviruses

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8 July 2018

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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8 July 2018

Pharmacokinetics of the antiviral agent 3-deazaneplanocin A.

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8 July 2018

The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia.

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Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia.

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21 January 2018

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.

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Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.

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Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.

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Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis in patients with acute myeloid leukemia

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24612037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24612037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24612037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations of p16 and p15 genes in acute leukemia with MLL gene rearrangements and their correlation with clinical features

1 reference

https://pubmed.ncbi.nlm.nih.gov/24612037

12 December 2020

based on heuristic

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Identifiers

10.1111/CAS.12386

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10 March 2020

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10 March 2020

PubMed publication ID

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10 March 2020

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